- A Stably Engineered, Suicidal Strain of Listeria monocytogenes Delivers Protein and/or DNA to Fully Differentiated Intestinal Epithelial Monolayers
[作者:Kuo, CY; Sinha, S; Jazayeri, JA; Pouton, CW,期刊:Molecular Pharmaceutics, 页码:1052-1061 , 文章类型: Article,,卷期:2009年6-4]
- We have generated a recombinant stable, suicidal Listeria monocytogenes strain (rs Delta 2) capable of delivering antigens as protein or DNA into nondividing intestinal epithelial cells. The rs Delta 2 strain was generat...
- Lipoplexes Targeting the CD44 Hyaluronic Acid Receptor for Efficient Transfection of Breast Cancer Cells
[作者:Surace, C; Arpicco, S; Dufay-Wojcicki, A; Marsaud, V; Bouclier, C; Clay, D; Cattel, L; Renoir, JM; Fattal, E,期刊:Molecular Pharmaceutics, 页码:1062-1073 , 文章类型: Article,,卷期:2009年6-4]
- Lipoplexes containing a hyaluronic acid -dioleoylphosphatidylethanolamine (HA-DOPE) conjugate were designed to target the CD44 receptor on breast cancer cells. Cationic liposomes composed of a mixture of [2-(2,3-didodecy...
- A Novel Type of Dual-Modality Molecular Probe for MR and Nuclear Imaging of Tumor: Preparation, Characterization and in Vivo Application
[作者:Liu, SJ; Jia, B; Qiao, RR; Yang, Z; Yu, ZL; Liu, ZF; Liu, K; Shi, JY; Han, OY; Wang, F; Gao, MY,期刊:Molecular Pharmaceutics, 页码:1074-1082 , 文章类型: Article,,卷期:2009年6-4]
- A novel dual-modality molecular probe composed of biocompatible Fe3O4 nanocrystal, monoclonal antibody and radionuclide was designed and prepared. All functional components in the dual-modality molecular probe, i.e., Fe3...
- Transferrin as a Luminal Target for Negatively Charged Liposomes in the Inflamed Colonic Mucosa
[作者:Tirosh, B; Khatib, N; Barenholz, Y; Nissan, A; Rubinstein, A,期刊:Molecular Pharmaceutics, 页码:1083-1091 , 文章类型: Article,,卷期:2009年6-4]
- The need for improved specificity in the local treatment of inflammatory bowel diseases (IBD) led us to use negatively charged liposomes to target the inflamed colonic epithelium, The purpose of the present study was to ...
- Rapid Photothermal Intracellular Drug Delivery Using Multiwalled Carbon Nanotubes
[作者:Levi-Polyachenko, NH; Merkel, EJ; Jones, BT; Carroll, DL; Stewart, JH,期刊:Molecular Pharmaceutics, 页码:1092-1099 , 文章类型: Article,,卷期:2009年6-4]
- Carbon nanotubes are unique materials that absorb infrared (IR) radiation, especially between 700 and 1100 rim, where body tissues are most transparent. Absorbed I R promotes molecular oscillation leading to efficient he...
- Drug-Eluting Stent for Delivery of Signal Pathway-Specific 1,3-Dipropyl-8-cyclopentyl Xanthine
[作者:Kang, E; Vedantham, K; Long, X; Dadara, M; Kwon, IK; Sturek, M; Park, K,期刊:Molecular Pharmaceutics, 页码:1110-1117 , 文章类型: Article,,卷期:2009年6-4]
- 1,3-Dipropyl-8-cyclopentyl xanthine (DPCPX) is a highly selective antagonist of the adenosine A, receptor (A,R). The A(1)R mediates mitogenic effects of adenosine in coronary artery smooth muscle cells (CASMC). DPCPX pla...
- Formulation and Stability of ltraconazole and Odanacatib Nanoparticles: Governing Physical Parameters
[作者:Kumar, V; Wang, L; Riebe, M; Tung, HH; Prud'homme, RK,期刊:Molecular Pharmaceutics, 页码:1118-1124 , 文章类型: Article,,卷期:2009年6-4]
- The successful formulation of itraconazole and odanacatib into nanoparticle form with diameters of 145 and 350 rim, respectively, using rapid, block copolymer-directed precipitation is presented. These are the smallest s...
- Multiple Triphenylphosphonium Cations Shuttle a Hydrophilic Peptide into Mitlochondria
[作者:Abu-Gosh, SE; Kolvazon, N; Tirosh, B; Ringel, I; Yavin, E,期刊:Molecular Pharmaceutics, 页码:1138-1144 , 文章类型: Article,,卷期:2009年6-4]
- A variety of diseases are related to mitochondrial dysfunction. Hence, the ability to transport drugs to mitochondria that are otherwise cell impermeable would be of great therapeutic potential. Triphenylphosphonium (TPP...
- Nucleotide Analogue Prodrug Tenofovir Disoproxil Enhances Lymphoid Cell Loading following Oral Administration in Monkeys
[作者:Durand-Gasselin, L; Van Rompay, KKA; Vela, JE; Henne, IN; Lee, WA; Rhodes, GR; Ray, AS,期刊:Molecular Pharmaceutics, 页码:1145-1151 , 文章类型: Article,,卷期:2009年6-4]
- The antiviral drug tenofovir (TFV) is orally administered as the fumarate salt of its disoproxil prodrug (TFV disoproxil fumarate (TDF)). TFV is a dianion at physiological pH and, as a result, has poor lipid membrane per...
- (-)-Epigallocatechin-3-gallate Inhibits Hsp90 Function by Impairing Hsp90 Association with Cochaperones in Pancreatic Cancer Cell Line Mia Paca-2
[作者:Li, YY; Zhang, T; Jiang, YQ; Lee, HF; Schwartz, SJ; Sun, DX,期刊:Molecular Pharmaceutics, 页码:1152-1159 , 文章类型: Article,,卷期:2009年6-4]
- (-)-Epigallocatechin-3-gallate [(-)-EGCG], the most abundant polyphenolic catechin in green tea, showed chemoprevention and anticancer activities. (-)-EGCG was reported to bind to the C-terminal domain of heat shock prot...
- In Vivo Studies on the Effect of Co-Encapsulation of CpG DNA and Antigen in Acid-Degradable Microparticle Vaccines
[作者:Beaudette, TT; Bachelder, EM; Cohen, JA; Obermeyer, AC; Broaders, KE; Frechet, JMJ; Kang, ES; Mende, I; Tseng, WW; Davidson, MG; Engleman, EG,期刊:Molecular Pharmaceutics, 页码:1160-1169 , 文章类型: Article,,卷期:2009年6-4]
- Protein-based vaccines have been explored as a safer alternative to traditional weakened or killed whole organism based vaccination strategies and have been investigated for their ability to activate the immune system ag...
- Rac-Mediated Macropinocytosis Is a Critical Route for Naked Plasmid DNA Transfer in Mice
[作者:Fumoto, S; Nishi, J; Ishii, H; Wang, X; Miyamoto, H; Yoshikawa, N; Nakashima, M; Nakamura, J; Nishida, K,期刊:Molecular Pharmaceutics, 页码:1170-1179 , 文章类型: Article,,卷期:2009年6-4]
- We have recently discovered the potential for in vivo naked plasmid DNA (pDNA) transfer into gastric serosal surface cells in mice. As pDNA are huge molecules, the mechanism of gene transfer without carriers and physical...
- Quantitative Expression Profile of Hepatobiliary Transporters in Sandwich Cultured Rat and Human Hepatocytes
[作者:Li, N; Bi, YA; Duignan, DB; Lai, YR,期刊:Molecular Pharmaceutics, 页码:1180-1189 , 文章类型: Article,,卷期:2009年6-4]
- As sandwich cultured (SC) hepatocytes can repolarize to form bile canalicular networks, allowing active excretion of compounds in a vectorial manner, the model has been widely used for assessing the transporter related c...
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