- A randomized trial of varenicline (Chantix) for the treatment of spinocerebellar ataxia type 3
[作者:Zesiewicz, TA; Greenstein, PE; Sullivan, KL; Wecker, L; Miller, A; Jahan, I; Chen, R; Perlman, SL,期刊:Neurology, 页码:545-550 , 文章类型: Article,,卷期:2012年78-8]
- Objective: The objective of this double-blind, placebo-controlled, randomized study was to evaluate the efficacy of varenicline (Chantix), a partial agonist at alpha 4 beta 2 neuronal nicotinic acetylcholine receptors us...
- Evidence-based guideline update: Intraoperative spinal monitoring with somatosensory and transcranial electrical motor evoked potentials Report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology and the American Clinical Neurophysiology Society
[作者:Nuwer, MR; Emerson, RG; Galloway, G; Legatt, AD; Lopez, J; Minahan, R; Yamada, T; Goodin, DS; Armon, C; Chaudhry, V; Gronseth, GS; Harden, CL,期刊:Neurology, 页码:585-589 , 文章类型: Article,,卷期:2012年78-8]
- Objective: To evaluate whether spinal cord intraoperative monitoring (IOM) with somatosensory and transcranial electrical motor evoked potentials (EPs) predicts adverse surgical outcomes. Methods: A panel of experts revi...
- Antigen microarrays identify CNS-produced autoantibodies in RRMS
[作者:Quintana, FJ; Farez, MF; Izquierdo, G; Lucas, M; Cohen, IR; Weiner, HL,期刊:Neurology, 页码:532-539 , 文章类型: Article,,卷期:2012年78-8]
- Objective: Multiple sclerosis (MS) is characterized by the local production of antibodies in the CNS and the presence of oligoclonal bands in the CSF. Antigen arrays allow the study of antibody reactivity against a large...
- Genotype-phenotype relationship in 2 SMA III patients with novel mutations in the Tudor domain
[作者:Fraidakis, MJ; Drunat, S; Maisonobe, T; Gerard, B; Pradat, PF; Meininger, V; Salachas, F,期刊:Neurology, 页码:551-556 , 文章类型: Article,,卷期:2012年78-8]
- Objective: We report the cases of 2 patients with late-onset spinal muscular atrophy (SMA) type III, who were hemizygous for SMN1 deletion and carriers of novel SMN1 intragenic missense mutations, and we investigate the ...
- GLUT1 mutations are a rare cause of familial idiopathic generalized epilepsy
[作者:Striano, P; Weber, YG; Toliat, MR; Schubert, J; Leu, C; Chaimana, R; Baulac, S; Guerrero, R; LeGuern, E; Lehesjoki, AE; Polvi, A; Robbiano, A; Serratosa, JM; Guerrini, R; Nurnberg, P; Sander, T; Zara, F; Lerche, H; Marini, C,期刊:Neurology, 页码:557-562 , 文章类型: Article,,卷期:2012年78-8]
- Objective: The idiopathic generalized epilepsies (IGE) are the most common genetically determined epilepsies. However, the underlying genes are largely unknown. We screened the SLC2A1 gene, encoding the glucose transport...
- Chitinase enzyme activity in CSF is a powerful biomarker of Alzheimer disease
[作者:Watabe-Rudolph, M; Song, Z; Lausser, L; Schnack, C; Begus-Nahrmann, Y; Scheithauer, MO; Rettinger, G; Otto, M; Tumani, H; Thal, DR; Attems, J; Jellinger, KA; Kestler, HA; von Arnim, CAF; Rudolph, KL,期刊:Neurology, 页码:569-577 , 文章类型: Article,,卷期:2012年78-8]
- Objective: DNA damage accumulation in brain is associated with the development of Alzheimer disease (AD), but newly identified protein markers of DNA damage have not been evaluated in the diagnosis of AD and other forms ...
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