- Dysregulation of Placental Endothelial Lipase in Obese Women With Gestational Diabetes Mellitus
[作者：Gauster, M; Hiden, U; van Poppel, M; Frank, S; Wadsack, C; Hauguel-de Mouzon, S; Desoye, G,期刊：Diabetes, 页码：2457-2464 , 文章类型： Article，,卷期：2011年60-10]
- OBJECTIVE-This study addressed the hypothesis that placental endothelial lipase (EL) expression is affected by pregnancies complicated by obesity and gestational diabetes mellitus (GDM). RESEARCH DESIGN AND METHODS-EL ex...
- Nrf2 Represses FGF21 During Long-Term High-Fat Diet-Induced Obesity in Mice
[作者：Chartoumpekis, DV; Ziros, PG; Psyrogiannis, AI; Papavassiliou, AG; Kyriazopoulou, VE; Sykiotis, GP; Habeos, IG,期刊：Diabetes, 页码：2465-2473 , 文章类型： Article，,卷期：2011年60-10]
- OBJECTIVE-Obesity is characterized by chronic oxidative stress. Fibroblast growth factor 21 (FGF21) has recently been identified as a novel hormone that regulates metabolism. NFE2-related factor 2 (Nrf2) is a transcripti...
- Inflammation Is Necessary for Long-Term but Not Short-Term High-Fat Diet Induced Insulin Resistance
[作者：Lee, YS; Li, PP; Huh, JY; Hwang, IJ; Lu, M; Kim, JI; Ham, M; Talukdar, S; Chen, A; Lu, WJ; Bandyopadhyay, GK; Schwendener, R; Olefsky, J; Kim, JB,期刊：Diabetes, 页码：2474-2483 , 文章类型： Article，,卷期：2011年60-10]
- OBJECTIVE-Tissue inflammation is a key factor underlying insulin resistance in established obesity. Several models of immuno-compromised mice are protected from obesity-induced insulin resistance. However, it is unanswer...
- Disruption of Hypoxia-Inducible Factor 1 in Adipocytes Improves Insulin Sensitivity and Decreases Adiposity in High-Fat Diet-Fed Mice
[作者：Jiang, CT; Qu, AJ; Matsubara, T; Chanturiya, T; Jou, W; Gavrilova, O; Shah, YM; Gonzalez, FJ,期刊：Diabetes, 页码：2484-2495 , 文章类型： Article，,卷期：2011年60-10]
- OBJECTIVE-Obesity, insulin resistance, and type 2 diabetes form a tightly correlated cluster of metabolic disorders in which adipose is one of the first affected tissues. The role of hypoxia and hypoxia-inducible factor ...
- Genetic Analysis of Adult-Onset Autoimmune Diabetes
[作者：Howson, JMM; Rosinger, S; Smyth, DJ; Boehm, BO; Todd, JA,期刊：Diabetes, 页码：2645-2653 , 文章类型： Article，,卷期：2011年60-10]
- OBJECTIVE-In contrast with childhood-onset type 1 diabetes, the genetics of autoimmune diabetes in adults are not well understood. We have therefore investigated the genetics of diabetes diagnosed in adults positive for ...
- Effects of Genetic Susceptibility for Type 2 Diabetes on the Evolution of Glucose Homeostasis Traits Before and After Diabetes Diagnosis Data From the DESIR Study
[作者：Gautier, A; Roussel, R; Lange, C; Piguel, X; Cauchi, S; Vol, S; Froguel, P; Balkau, B; Bonnet, F,期刊：Diabetes, 页码：2654-2663 , 文章类型： Article，,卷期：2011年60-10]
- OBJECTIVE-To assess the impact of genetic susceptibility on evolution toward type 2 diabetes (T2D) by analyzing time trajectories of fasting glucose, glycated hemoglobin (HbA(1c)), insulin sensitivity (homeostasis model ...
- Obesity-Associated Hepatosteatosis and Impairment of Glucose Homeostasis Are Attenuated by Haptoglobin Deficiency
[作者：Lisi, S; Gamucci, O; Vottari, T; Scabia, G; Funicello, M; Marchi, M; Galli, G; Arisi, I; Brandi, R; D'Onofrio, M; Pinchera, A; Santini, F; Maffei, M,期刊：Diabetes, 页码：2496-2505 , 文章类型： Article，,卷期：2011年60-10]
- OBJECTIVE-Haptoglobin (Hp) is upregulated in both inflammation and obesity. The low chronic inflammatory state, caused by massive adipose tissue macrophage (ATM) infiltration found in obesity, and low adiponectin have be...
- Advanced Glycation End Products Are Direct Modulators of beta-Cell Function
[作者：Coughlan, MT; Yap, FYT; Tong, DCK; Andrikopoulos, S; Gasser, A; Thallas-Bonke, V; Webster, DE; Miyazaki, J; Kay, TW; Slattery, RM; Kaye, DM; Drew, BG; Kingwell, BA; Fourlanos, S; Groop, PH; Harrison, LC; Knip, M; Forbes, JM,期刊：Diabetes, 页码：2523-2532 , 文章类型： Article，,卷期：2011年60-10]
- OBJECTIVE-Excess accumulation of advanced glycation end products (AGEs) contributes to aging and chronic diseases. We aimed to obtain evidence that exposure to AGEs plays a role in the development of type 1 diabetes (T1D...
- Mechanisms of Control of the Free Ca(2+) Concentration in the Endoplasmic Reticulum of Mouse Pancreatic beta-Cells Interplay With Cell Metabolism and [Ca(2+)](c) and Role of SERCA2b and SERCA3
[作者：Ravier, MA; Daro, D; Roma, LP; Jonas, JC; Cheng-Xue, R; Schuit, FC; Gilon, P,期刊：Diabetes, 页码：2533-2545 , 文章类型： Article，,卷期：2011年60-10]
- OBJECTIVE-Sarco-endoplasmic reticulum Ca(2+)-ATPase 2b (SERCA2b) and SERCA3 pump Ca(2+) in the endoplasmic reticulum (ER) of pancreatic beta-cells. We studied their role in the control of the free ER Ca(2+) concentration...
- Activation of Protein Kinase C-zeta in Pancreatic beta-Cells In Vivo Improves Glucose Tolerance and Induces beta-Cell Expansion via mTOR Activation
[作者：Velazquez-Garcia, S; Valle, S; Rosa, TC; Takane, KK; Demirci, C; Alvarez-Perez, JC; Mellado-Gil, JM; Ernst, S; Scott, DK; Vasavada, RC; Alonso, LC; Garcia-Ocana, A,期刊：Diabetes, 页码：2546-2559 , 文章类型： Article，,卷期：2011年60-10]
- OBJECTIVE-PKC-zeta activation is a key signaling event for growth factor-induced beta-cell replication in vitro. However, the effect of direct PKC-zeta activation in the beta-cell in vivo is unknown. In this study, we ex...
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