- CD14 Modulates Inflammation-Driven Insulin Resistance
[作者：Fernandez-Real, JM; del Pulgar, SP; Luche, E; Moreno-Navarrete, JM; Waget, A; Serino, M; Sorianello, E; Sanchez-Pla, A; Pontaque, FC; Vendrell, J; Chacon, MR; Ricart, W; Burcelin, R; Zorzano, A,期刊：Diabetes, 页码：2179-2186 , 文章类型： Article，,卷期：2011年60-8]
- OBJECTIVE-The study objective was to evaluate the possible role of the macrophage molecule CD14 in insulin resistance. RESEARCH DESIGN AND METHODS-The effects of recombinant human soluble CD14 (rh-sCD14) on insulin sensi...
- The RANKL/RANK/OPG Signaling Pathway Mediates Medial Arterial Calcification in Diabetic Charcot Neuroarthropathy
[作者：Ndip, A; Williams, A; Jude, EB; Serracino-Inglott, F; Richardson, S; Smyth, JV; Boulton, AJM; Alexander, MY,期刊：Diabetes, 页码：2187-2196 , 文章类型： Article，,卷期：2011年60-8]
- OBJECTIVE-The receptor activator of nuclear factor-kappa B (RANK), RANK ligand (RANKL), and osteoprotegerin (OPG) signaling pathway (RANKL/RANK/OPG signaling) is implicated in the osteolysis associated with diabetic Char...
- Novel Locus FER Is Associated With Serum HMW Adiponectin Levels
[作者：Qi, L; Menzaghi, C; Salvemini, L; De Bonis, C; Trischitta, V; Hu, FB,期刊：Diabetes, 页码：2197-2201 , 文章类型： Article，,卷期：2011年60-8]
- OBJECTIVE-High molecular weight (HMW) adiponectin is a predominant isoform of circulating adiponectin and has been related to type 2 diabetes. Previous linkage studies suggest that different genetic components might be i...
- Macrophage Deletion of SOCS1 Increases Sensitivity to LPS and Palmitic Acid and Results in Systemic Inflammation and Hepatic Insulin Resistance
[作者：Sachithanandan, N; Graham, KL; Galic, S; Honeyman, JE; Fynch, SL; Hewitt, KA; Steinberg, GR; Kay, TW,期刊：Diabetes, 页码：2023-2031 , 文章类型： Article，,卷期：2011年60-8]
- OBJECTIVE-Macrophage secretion of proinflammatory cytokines contributes to the pathogenesis of obesity-related insulin resistance. An important regulator of inflammation is the suppressor of cytokine signaling-1 (SOCS1),...
- Storage of Circulating Free Fatty Acid in Adipose Tissue of Postabsorptive Humans Quantitative Measures and Implications for Body Fat Distribution
[作者：Koutsari, C; Ali, AH; Mundi, MS; Jensen, MD,期刊：Diabetes, 页码：2032-2040 , 文章类型： Article，,卷期：2011年60-8]
- OBJECTIVE-Preferential upper-body fat gain, a typical male pattern, is associated with a greater cardiometabolic risk. Regional differences in lipolysis and meal fat storage cannot explain sex differences in body fat dis...
- Severity of Diabetes Governs Vascular Lipoprotein Lipase by Affecting Enzyme Dimerization and Disassembly
[作者：Wang, Y; Puthanveetil, P; Wang, F; Kim, MS; Abrahani, A; Rodrigues, B,期刊：Diabetes, 页码：2041-2050 , 文章类型： Article，,卷期：2011年60-8]
- OBJECTIVE-In diabetes, when glucose consumption is restricted, the heart adapts to use fatty acid (FA) exclusively. The majority of FA provided to the heart comes from the breakdown of circulating triglyceride (TG), a pr...
- Reduction in Reactive Oxygen Species Production by Mitochondria From Elderly Subjects With Normal and Impaired Glucose Tolerance
[作者：Ghosh, S; Lertwattanarak, R; Lefort, N; Molina-Carrion, M; Joya-Galeana, J; Bowen, BP; Garduno-Garcia, JD; Abdul-Ghani, M; Richardson, A; DeFronzo, RA; Mandarino, L; Van Remmen, H; Musi, N,期刊：Diabetes, 页码：2051-2060 , 文章类型： Article，,卷期：2011年60-8]
- OBJECTIVE-Aging increases the risk of developing impaired glucose tolerance (IGT) and type 2 diabetes. It has been proposed that increased reactive oxygen species (ROS) generation by dysfunctional mitochondria could play...
- Endothelin-1 Reduces Glucose Uptake in Human Skeletal Muscle In Vivo and In Vitro
[作者：Shemyakin, A; Salehzadeh, F; Duque-Guimaraes, DE; Bohm, F; Rullman, E; Gustafsson, T; Pernow, J; Krook, A,期刊：Diabetes, 页码：2061-2067 , 文章类型： Article，,卷期：2011年60-8]
- OBJECTIVE-Endothelin (ET)-1 is a vasoconstrictor and proinflammatory peptide that may interfere with glucose uptake. Our objective was to investigate whether exogenous ET-1 affects glucose uptake in the forearm of indivi...
- Heterozygous Inactivation of the Na/Ca Exchanger Increases Glucose-Induced Insulin Release, beta-Cell Proliferation, and Mass
[作者：Nguidjoe, E; Sokolow, S; Bigabwa, S; Pachera, N; D'Amico, E; Allagnat, F; Vanderwinden, JM; Sener, A; Manto, M; Depreter, M; Mast, J; Joanny, G; Montanya, E; Rahier, J; Cardozo, AK; Eizirik, DL; Schurmans, S; Herchuelz, A,期刊：Diabetes, 页码：2076-2085 , 文章类型： Article，,卷期：2011年60-8]
- OBJECTIVE-We have previously shown that overexpression of the Na-Ca exchanger (NCX1), a protein responsible for Ca2+ extrusion from cells, increases beta-cell programmed cell death (apoptosis) and reduces beta-cell proli...
- Progressive Erosion of beta-Cell Function Precedes the Onset of Hyperglycemia in the NOD Mouse Model of Type 1 Diabetes
[作者：Ize-Ludlow, D; Lightfoot, YL; Parker, M; Xue, S; Wasserfall, C; Haller, MJ; Schatz, D; Becker, DJ; Atkinson, MA; Mathews, CE,期刊：Diabetes, 页码：2086-2091 , 文章类型： Article，,卷期：2011年60-8]
- OBJECTIVE-A progressive decline in insulin responses to glucose was noted in individuals before the onset of type 1 diabetes. We determined whether such abnormalities occurred in prediabetic NOD mice the prototypic model...
- In Vivo Misfolding of Proinsulin Below the Threshold of Frank Diabetes
[作者：Hodish, I; Absood, A; Liu, L; Liu, M; Haataja, L; Larkin, D; Al-Khafaji, A; Zaki, A; Arvan, P,期刊：Diabetes, 页码：2092-2101 , 文章类型： Article，,卷期：2011年60-8]
- OBJECTIVE-Endoplasmic reticulum (ER) stress has been described in pancreatic beta-cells after onset of diabetes a situation in which failing beta-cells have exhausted available compensatory mechanisms. Herein we have com...
- Anti-Islet Autoantibodies Trigger Autoimmune Diabetes in the Presence of an Increased Frequency of Islet-Reactive CD4 T Cells
[作者：Silva, DG; Daley, SR; Hogan, J; Lee, SK; Teh, CE; Hu, DY; Lam, KP; Goodnow, CC; Vinuesa, CG,期刊：Diabetes, 页码：2102-2111 , 文章类型： Article，,卷期：2011年60-8]
- OBJECTIVE-To define cellular mechanisms by which B cells promote type 1 diabetes. RESEARCH DESIGN AND METHODS-The study measured islet-specific CD4 T cell regulation in T-cell receptor transgenic mice with elevated frequ...
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