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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共21条记录   Mutations of the Same Conserved Glutamate Residue in NBD2 of the Sulfonylurea Receptor 1 Subunit of the K-ATP Channel Can Result in Either Hyperinsulinism or Neonatal Diabetes [作者：Mannikko, R; Flanagan, SE; Sim, XL; Segal, D; Hussain, K; Ellard, S; Hattersley, AT; Ashcroft, FM,期刊：Diabetes, 页码：1813-1822 , 文章类型： Article，,卷期：2011年60-6] OBJECTIVE-Two novel mutations (E1506D, E1506G) in the nucleotide-binding domain 2 (NBD2) of the ATP-sensitive K+ channel (K-ATP channel) sulfonylurea receptor 1 (SUR1) subunit were detected heterozygously in patients wit... Efficacy of Metreleptin in Obese Patients With Type 2 Diabetes: Cellular and Molecular Pathways Underlying Leptin Tolerance [作者：Moon, HS; Matarese, G; Brennan, AM; Chamberland, JP; Liu, XW; Fiorenza, CG; Mylvaganam, GH; Abanni, L; Carbone, F; Williams, CJ; De Paoli, AM; Schneider, BE; Mantzoros, CS,期刊：Diabetes, 页码：1647-1656 , 文章类型： Article，,卷期：2011年60-6] OBJECTIVE-Metreleptin has been efficacious in improving metabolic control in patients with lipodystrophy, but its efficacy has not been tested in obese patients with type 2 diabetes. RESEARCH DESIGN AND METHODS-We studie... Stimulating IL-13 Receptors on T cells: A New Pathway for Tolerance Induction in Diabetes? [作者：Wong, FS,期刊：Diabetes, 页码：1657-1659 , 文章类型： Editorial Material，,卷期：2011年60-6] Liver Enzymes Are Associated With Hepatic Insulin Resistance, Insulin Secretion, and Glucagon Concentration in Healthy Men and Women [作者：Bonnet, F; Ducluzeau, PH; Gastaldelli, A; Laville, M; Anderwald, CH; Konrad, T; Mari, A; Balkan, B,期刊：Diabetes, 页码：1660-1667 , 文章类型： Article，,卷期：2011年60-6] OBJECTIVE-The pathophysiological mechanisms to explain the association between risk of type 2 diabetes and elevated concentrations of -gamma-glutamyltransferase (GGT) and alanineamino-transferase (ALT) remain poorly char... Cross-Talk Between Interferon-gamma and Hedgehog Signaling Regulates Adipogenesis [作者：Todoric, J; Strobl, B; Jais, A; Boucheron, N; Bayer, M; Amann, S; Lindroos, J; Teperino, R; Prager, G; Bilban, M; Ellmeier, W; Krempler, F; Muller, M; Wagner, O; Patsch, W; Pospisilik, JA; Esterbauer, H,期刊：Diabetes, 页码：1668-1676 , 文章类型： Article，,卷期：2011年60-6] OBJECTIVE-T cells and level of the cytokine interferon-gamma (IFN-gamma) are increased in adipose tissue in obesity. Hedgehog (Fib) signaling has been shown to potently inhibit white adipocyte differentiation. In light o... Insulin Restores Gestational Diabetes Mellitus Reduced Adenosine Transport Involving Differential Expression of Insulin Receptor Isoforms in Human Umbilical Vein Endothelium [作者：Westermeier, F; Salomon, C; Gonzalez, M; Puebla, C; Guzman-Gutierrez, E; Cifuentes, F; Leiva, A; Casanello, P; Sobrevia, L,期刊：Diabetes, 页码：1677-1687 , 文章类型： Article，,卷期：2011年60-6] OBJECTIVE-To determine whether insulin reverses gestational diabetes mellitus (GDM)-reduced expression and activity of human equilibrative nucleoside transporters 1 (hENT1) in human umbilical vein endothelium cells (HUVE... Lack of Interleukin-1 Receptor I (IL-1RI) Protects Mice From High-Fat Diet Induced Adipose Tissue Inflammation Coincident With Improved Glucose Homeostasis [作者：McGillicuddy, FC; Harford, KA; Reynolds, CM; Oliver, E; Claessens, M; Mills, KHG; Roche, HM,期刊：Diabetes, 页码：1688-1698 , 文章类型： Article，,卷期：2011年60-6] OBJECTIVE-High-fat diet (HFD)-induced adipose tissue inflammation is a critical feature of diet-induced insulin resistance (IR); however, the contribution of interleukin-1 receptor I (IL-1RI)-mediated signals to this phe... Partial Reversibility of Hypothalamic Dysfunction and Changes in Brain Activity After Body Mass Reduction in Obese Subjects [作者：van de Sande-Lee, S; Pereira, FRS; Cintra, DE; Fernandes, PT; Cardoso, AR; Garlipp, CR; Chaim, EA; Pareja, JC; Geloneze, B; Li, LM; Cendes, F; Velloso, LA,期刊：Diabetes, 页码：1699-1704 , 文章类型： Article，,卷期：2011年60-6] OBJECTIVE-Inflammation and dysfunction of the hypothalamus are common features of experimental obesity. However, it is unknown whether obesity and massive loss of body mass can modify the immunologic status or the functi... In Vivo Conditional Pax4 Overexpression in Mature Islet beta-Cells Prevents Stress-Induced Hyperglycemia in Mice [作者：He, KHH; Lorenzo, PI; Brun, T; Moreno, CMJ; Aeberhard, D; Ortega, JV; Cornu, M; Thorel, F; Gjinovci, A; Thorens, B; Herrera, PL; Meda, P; Wollheim, CB; Gauthier, BR,期刊：Diabetes, 页码：1705-1715 , 文章类型： Article，,卷期：2011年60-6] OBJECTIVE-To establish the role of the transcription factor Pax4 in pancreatic islet expansion and survival in response to physiological stress and its impact on glucose metabolism, we generated transgenic mice condition... IL-beta R alpha 1 Expression on beta-Cell Specific T Cells in NOD Mice [作者：Rasche, SS; Phillips, M; McInerney, MF; Sercarz, EE; Quinn, A,期刊：Diabetes, 页码：1716-1725 , 文章类型： Article，,卷期：2011年60-6] OBJECTIVE-Immunotherapy using peptides from the beta-cell antigen GAD65 can preserve glucose homeostasis in diabetes-prone NOD mice; however, the precise mechanisms that arrest islet-reactive T cells remain unresolved. O... HLA-A2 Matched Peripheral Blood Mononuclear Cells From Type 1 Diabetic Patients, but Not Nondiabetic Donors, Transfer Insulitis to NOD-scid/gamma c(null)/HLA-A2 Transgenic Mice Concurrent With the Expansion of Islet-Specific CD8(+) T cells [作者：Whitfield-Larry, F; Young, EF; Talmage, G; Fudge, E; Azam, A; Patel, S; Largay, J; Byrd, W; Buse, J; Calikoglu, AS; Shultz, LD; Frelinger, JA,期刊：Diabetes, 页码：1726-1733 , 文章类型： Article，,卷期：2011年60-6] OBJECTIVE-Type 1 diabetes is an autoimmune disease characterized by the destruction of insulin-producing beta-cells. NOD mice provide a useful tool for understanding disease pathogenesis and progression. Although much ha... Altered Skeletal Muscle Lipase Expression and Activity Contribute to Insulin Resistance in Humans [作者：Badin, PM; Louche, K; Mairal, A; Liebisch, G; Schmitz, G; Rustan, AC; Smith, SR; Langin, D; Moro, C,期刊：Diabetes, 页码：1734-1742 , 文章类型： Article，,卷期：2011年60-6] OBJECTIVE-Insulin resistance is associated with elevated content of skeletal muscle lipids, including triacylglycerols (TAGs) and diacylglycerols (DAGs). DAGs are by-products of lipolysis consecutive to TAG hydrolysis by... Diabetic Visceral Hypersensitivity Is Associated With Activation of Mitogen-Activated Kinase in Rat Dorsal Root Ganglia [作者：Grabauskas, G; Heldsinger, A; Wu, XY; Xu, DB; Zhou, SY; Owyang, C,期刊：Diabetes, 页码：1743-1751 , 文章类型： Article，,卷期：2011年60-6] OBJECTIVE Diabetic patients often experience visceral hypersensitivity and anorectal dysfunction. We hypothesize that the enhanced excitability of colon projecting dorsal root ganglia (DRG) neurons observed in diabetes i... Risk factors for renal dysfunction in type 2 diabetes: U.K. (vol 55, pg 1832, 2006) [作者：Retnakaran, R; Cull, CA; Thorne, KI; Adler, AI; Holman, RR,期刊：Diabetes, 页码：1823-1823 , 文章类型： Correction，,卷期：2011年60-6] Postprandial and Fasting Hepatic Glucose Fluxes in Long-Standing Type 1 Diabetes [作者：Kacerovsky, M; Jones, J; Schmid, AI; Barosa, C; Lettner, A; Kacerovsky-Bielesz, G; Szendroedi, J; Chmelik, M; Nowotny, P; Chandramouli, V; Wolzt, M; Roden, M,期刊：Diabetes, 页码：1752-1758 , 文章类型： Article，,卷期：2011年60-6] OBJECTIVE-Intravenous insulin infusion partly improves liver glucose fluxes in type 1 diabetes (T1D). This study tests the hypothesis that continuous subcutaneous insulin infusion (CSII) normalizes hepatic glycogen metab... Diabetes Adversely Affects Macrophages During Atherosclerotic Plaque Regression in Mice [作者：Parathath, S; Grauer, L; Huang, LS; Sanson, M; Distel, E; Goldberg, IJ; Fisher, EA,期刊：Diabetes, 页码：1759-1769 , 文章类型： Article，,卷期：2011年60-6] OBJECTIVE-Patients with diabetes have increased cardiovascular risk. Atherosclerosis in these patients is often associated with increased plaque macrophages and dyslipidemia. We hypothesized that diabetic atherosclerosis...