Introduction: This paper is an update of a previous paper I published in Expert Opinion of Therapeutic Patents in 2008. The paper was a survey of patenting activity in the fields of atherosclerosis and dyslipidaemia, whi...
Introduction: Several studies underlined the critical role of histamine H4 receptor (H4R) in inflammation, thus H4 modulators have been suggested as promising drug candidates in inflammatory diseases. First H4 ligands ty...
Introduction: Due to the increase in knowledge about cancer pathways, there is a growing interest in finding novel potential drugs. Quinazoline is one of the most widespread scaffolds amongst bioactive compounds. A numbe...
Introduction: Pyrazolines are well-known and important nitrogen-containing five-membered ring heterocyclic compounds. Various methods have been worked out for their synthesis. Several pyrazoline derivatives have been fou...
Introduction: The p21-activated kinase (PAK) family of serine/threonine protein kinases is activated by binding to the small (p21) GTP-binding proteins Cdc42 and Rac. The PAK family plays important roles in cytoskeletal ...
Introduction: Toxoplasma gondii is an opportunistic protozoan parasite responsible for toxoplasmosis. T. gondii is able to infect a wide range of hosts, particularly humans and warm-blooded animals. Toxoplasmosis can be ...
A small number of novel 7-(1-alkylpyrazol-4-yl)-N-[(4-fluoro-4-piperidyl) methyl]-1,6-naphthyridin-5-amines are claimed. The compounds are Syk kinase inhibitors useful in the treatment of allergic and inflammatory diseas...
This patent application claims an interesting and novel combination of passive accumulation of drug nanocrystals within diseased tissue, in combination with active uptake of the nanocrystals by diseased cells. The patent...