- Reverse Conformational Changes of the Light Chain-Binding Domain of Myosin V and VI Processive Motor Heads during and after Hydrolysis of ATP by Small-Angle X-Ray Solution Scattering
[作者:Sugimoto, Y; Sato, O; Watanabe, S; Ikebe, R; Ikebe, M; Wakabayashi, K,期刊:Journal of Molecular Biology, 页码:420-435 , 文章类型: Article,,卷期:2009年392-2]
- We used small-angle X-ray solution scattering (SAXS) technique to investigate the nucleotide-mediated conformational changes of the head domains [subfragment 1 (S1)] of myosin V and VI processive motors that govern their...
- Specific Interactions between the Ferredoxin and Terminal Oxygenase Components of a Class IIB Rieske Nonheme Iron Oxygenase, Carbazole 1,9a-Dioxygenase
[作者:Inoue, K; Ashikawa, Y; Umeda, T; Abo, M; Katsuki, J; Usami, Y; Noguchi, H; Fujimoto, Z; Terada, T; Yamane, H; Nojiri, H,期刊:Journal of Molecular Biology, 页码:436-451 , 文章类型: Article,,卷期:2009年392-2]
- Carbazole 1,9a-dioxygenase (CARDO) consists of terminal oxygenase (Oxy), ferredoxin (Fd), and ferredoxin reductase (Red) components and is a member of the Rieske nonheme iron oxygenases. Rieske nonheme iron oxygenases ar...
- Highly Cooperative Recruitment of Ets-1 and Release of Autoinhibition by Pax5
[作者:Fitzsimmons, D; Lukin, K; Lutz, R; Garvie, CW; Wolberger, C; Hagman, J,期刊:Journal of Molecular Biology, 页码:452-464 , 文章类型: Article,,卷期:2009年392-2]
- Pax5 (paired box binding factor 5) is a critical regulator of transcription and lineage commitment in B lymphocytes. In B cells, mb-1 (Ig-alpha/immunoglobulin-associated alpha) promoter transcription is activated by Pax5...
- Characterization of Two Novel Aldo-Keto Reductases from Arabidopsis: Expression Patterns, Broad Substrate Specificity, and an Open Active-Site Structure Suggest a Role in Toxicant Metabolism Following Stress
[作者:Simpson, PJ; Tantitadapitak, C; Reed, AM; Mather, OC; Bunce, CM; White, SA; Ride, JP,期刊:Journal of Molecular Biology, 页码:465-480 , 文章类型: Article,,卷期:2009年392-2]
- Aldo-keto reductases (AKRs) are widely distributed in nature and play numerous roles in the metabolism of steroids, sugars, and other carbonyls. They have also frequently been implicated in the metabolism of exogenous an...
- Dicamba Monooxygenase: Structural Insights into a Dynamic Rieske Oxygenase that Catalyzes an Exocyclic Monooxygenation
[作者:D'Ordine, RL; Rydel, TJ; Storek, MJ; Sturman, EJ; Moshiri, F; Bartlett, RK; Brown, GR; Eilers, RJ; Dart, C; Qi, YL; Flasinski, S; Franklin, SJ,期刊:Journal of Molecular Biology, 页码:481-497 , 文章类型: Article,,卷期:2009年392-2]
- Dicamba (2-methoxy-3,6-dichlorobenzoic acid) O-demethylase (DMO) is the terminal Rieske oxygenase of a three-component system that includes a ferredoxin and a reductase. It catalyzes the NADH-dependent oxidative demethyl...
- Crystal Structure of Dicamba Monooxygenase: A Rieske Nonheme Oxygenase that Catalyzes Oxidative Demethylation
[作者:Dumitru, R; Jiang, WZ; Weeks, DP; Wilson, MA,期刊:Journal of Molecular Biology, 页码:498-510 , 文章类型: Article,,卷期:2009年392-2]
Dicamba (3,6-dichloro-2-methoxybenzoic acid) is a widely used herbicide that is efficiently degraded by soil microbes. These microbes use a novel Rieske nonheme oxygenase, dicamba monooxygenase (DMO), to catalyze the ...
- Designing Out Disulfide Bonds of Leech Carboxypeptidase Inhibitor: Implications for Its Folding, Stability and Function
[作者:Arolas, JL; Castillo, V; Bronsoms, S; Aviles, FX; Ventura, S,期刊:Journal of Molecular Biology, 页码:529-546 , 文章类型: Article,,卷期:2009年392-2]
- Leech carboxypeptidase inhibitor (LCI) is a 67-residue, tight-binding metallocarboxypeptidase inhibitor composed of a compact domain with a five-stranded p-sheet and a short alpha-helix that are strongly stabilized by fo...
- Structure and Uncoating of Immature Adenovirus
[作者:Perez-Berna, AJ; Marabini, R; Scheres, SHW; Menendez-Conejero, R; Dmitriev, IP; Curiel, DT; Mangel, WF; Flint, SJ; Martin, CS,期刊:Journal of Molecular Biology, 页码:547-557 , 文章类型: Article,,卷期:2009年392-2]
- Maturation via proteolytic processing is a common trait in the viral world and is often accompanied by large conformational changes and rearrangements in the capsid. The adenovirus protease has been shown to play a dual ...
- Steric and Electrostatic Effects at the C2 Atom Substituent Influence Replication and Miscoding of the DNA Deamination Product Deoxyxanthosine and Analogs by DNA Polymerases
[作者:Zhang, HD; Bren, U; Kozekov, ID; Rizzo, CJ; Stec, DF; Guengerich, FP,期刊:Journal of Molecular Biology, 页码:251-269 , 文章类型: Article,,卷期:2009年392-2]
- Deoxyinosine (dI) and deoxyxanthosine (dX) are both formed in DNA at appreciable levels in vivo by deamination of deoxyadenosine (dA) and deoxyguanosine (dG), respectively, and can miscode. Structure-activity relationshi...
- Amino Acid Architecture That Influences dNTP Insertion Efficiency in Y-Family DNA Polymerase V of E-coli
[作者:Seo, KY; Yin, J; Donthamsetti, P; Chandani, S; Lee, CH; Loechler, EL,期刊:Journal of Molecular Biology, 页码:270-282 , 文章类型: Article,,卷期:2009年392-2]
- Y-family DNA polymerases; (DNAPs) are often required in cells to synthesize past DNA-containing lesions, such as [+ta]-B[a]P-N-2-dG, which is the major adduct of the potent mutagen/carcinogen benzo[a]pyrene. The current ...
- Tests of the Single-hit DNA Damage Model
[作者:Spangler, R; Goddard, NL; Spangler, DN; Thaler, DS,期刊:Journal of Molecular Biology, 页码:283-300 , 文章类型: Article,,卷期:2009年392-2]
- The algebra of target theory for damage by radiation was laid out by Atwood and Norman in 1949. Their equations provide a widely embraced framework for distinguishing single-hit and multi-hit mechanisms of damage. The pr...
- Syncytin-2 Plays an Important Role in the Fusion of Human Trophoblast Cells
[作者:Vargas, A; Moreau, J; Landry, S; LeBellego, F; Toufaily, C; Rassart, E; Lafond, J; Barbeau, B,期刊:Journal of Molecular Biology, 页码:301-318 , 文章类型: Article,,卷期:2009年392-2]
- Human endogenous retrovirus (HERV)-encoded Syncytin-1 has been suggested to play a major role in trophoblast cell fusion and thereby placenta development. However, recent studies have strongly suggested that other HERV e...
- Identification and Structural Analysis of a Novel Carboxysome Shell Protein with Implications for Metabolite Transport
[作者:Klein, MG; Zwart, P; Bagby, SC; Cai, F; Chisholm, SW; Heinhorst, S; Cannon, GC; Kerfeld, CA,期刊:Journal of Molecular Biology, 页码:319-333 , 文章类型: Article,,卷期:2009年392-2]
- Bacterial microcompartments (BMCs) are polyhedral bodies, composed entirely of proteins, that function as organelles in bacteria; they promote subcellular processes by encapsulating and co-localizing targeted enzymes wit...
- A Common Structural Basis for pH- and Calmodulin-mediated Regulation in Plant Glutamate Decarboxylase
[作者:Gut, H; Dominici, P; Pilati, S; Astegno, A; Petoukhov, MV; Svergun, DI; Grutter, MG; Capitani, G,期刊:Journal of Molecular Biology, 页码:334-351 , 文章类型: Article,,卷期:2009年392-2]
- Glutamate decarboxylase (Gad) catalyzes glutamate to gamma-aminobutyrate conversion. Plant Gad is a similar to 340 kDa hexamer, involved in development and stress response, and regulated by pH and binding of Ca2+/calmodu...
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