- In vitro Unfolding and Refolding of the Small Multidrug Transporter EmrE
[作者:Miller, D; Charalambous, K; Rotem, D; Schuldiner, S; Curnow, P; Booth, PJ,期刊:Journal of Molecular Biology, 页码:815-832 , 文章类型: Article,,卷期:2009年393-4]
- The composition of the lipid bilayer is increasingly being recognised as important for the regulation of integral membrane protein folding and function, both in vivo and in vitro. The folding of only a few membrane prote...
- An Integrative Approach Combining Noncovalent Mass Spectrometry, Enzyme Kinetics and X-ray Crystallography to Decipher Tgt Protein-Protein and Protein-RNA Interaction
[作者:Ritschel, T; Atmanene, C; Reuter, K; Van Dorsselaer, A; Sanglier-Cianferani, S; Klebe, G,期刊:Journal of Molecular Biology, 页码:833-847 , 文章类型: Article,,卷期:2009年393-4]
- The tRNA-modifying enzyme tRNA-guanine transglycosylase (Tgt) is a putative target for new selective antibiotics against Shigella bacteria. The formation of a Tgt homodimer was suggested on the basis of several crystal s...
- PILZ Protein Structure and Interactions with PILB and the FIMX EAL Domain: Implications for Control of Type IV Pilus Biogenesis
[作者:Guzzo, CR; Salinas, RK; Andrade, MO; Farah, CS,期刊:Journal of Molecular Biology, 页码:848-866 , 文章类型: Article,,卷期:2009年393-4]
- The PilZ protein was originally identified as necessary for type IV pilus (T4P) biogenesis. Since then, a large and diverse family of bacterial PilZ homology domains have been identified, some of which have been implicat...
- Structural Evidence for a Sequential Release Mechanism for Activation of Heterotrimeric G Proteins
[作者:Kapoor, N; Menon, ST; Chauhan, R; Sachdev, P; Sakmar, TP,期刊:Journal of Molecular Biology, 页码:882-897 , 文章类型: Article,,卷期:2009年393-4]
- Heptahelical G-protein (heterotrimeric guanine nucleofide-binding protein)-coupled receptors couple to heterotrimeric G proteins to relay extracellular signals to intracellular signaling networks, but the molecular mecha...
- Illuminating Solution Responses of a LOV Domain Protein with Photocoupled Small-Angle X-Ray Scattering
[作者:Lamb, JS; Zoltowski, BD; Pabit, SA; Li, L; Crane, BR; Pollack, L,期刊:Journal of Molecular Biology, 页码:909-919 , 文章类型: Article,,卷期:2009年393-4]
- The PAS-LOV domain is a signal-transducing component found in a large variety of proteins that is responsible for sensing different stimuli such as light, oxygen, and voltage. The LOV protein VVD regulates blue light res...
- Serendipitous Fatty Acid Binding Reveals the Structural Determinants for Ligand Recognition in Apolipoprotein M
[作者:Sevvana, M; Ahnstrom, J; Egerer-Sieber, C; Lange, HA; Dahlback, B; Muller, YA,期刊:Journal of Molecular Biology, 页码:920-936 , 文章类型: Article,,卷期:2009年393-4]
- Apolipoprotein M (ApoM) is a 25-kDa HDL-associated apolipoprotein and a member of the lipocalin family of proteins. Mature apoM retains its signal peptide, which serves as a lipid anchor attaching apoM to the lipoprotein...
- Structure-Function Analysis of the Acyl Carrier Protein Synthase (AcpS) from Mycobacterium tuberculosis
[作者:Dym, O; Albeck, S; Peleg, Y; Schwarz, A; Shakked, Z; Burstein, Y; Zimhony, O,期刊:Journal of Molecular Biology, 页码:937-950 , 文章类型: Article,,卷期:2009年393-4]
- We have solved the crystal structure of the acyl carrier protein synthase (AcpS) from Mycobacterium tuberculosis (Mtb) at 1.95 angstrom resolution. AcpS, a 4-phosphopantetheinyl transferase, activates two distinct acyl c...
- Structural Basis for Substrate Recognition and Specificity in Aklavinone-11-Hydroxylase from Rhodomycin Biosynthesis
[作者:Lindqvist, Y; Koskiniemi, H; Jansson, A; Sandalova, T; Schnell, R; Liu, ZL; Mantsala, P; Niemi, J; Schneider, G,期刊:Journal of Molecular Biology, 页码:966-977 , 文章类型: Article,,卷期:2009年393-4]
In the biosynthesis of several anthracyclines, aromatic polyketides produced by many Streptomyces species, the aglycone core is modified by a specific flavin adenine dinucleotide (FAD)- and NAD(P)H-dependent aklavinon...
|