- Switching from an Induced-Fit to a Lock-and-Key Mechanism in an Aminoacyl-tRNA Synthetase with Modified Specificity
[作者：Schmitt, E; Tanrikulu, IC; Yoo, TH; Panvert, M; Tirrell, DA; Mechulam, Y,期刊：Journal of Molecular Biology, 页码：843-851 , 文章类型： Article，,卷期：2009年394-5]
- Methionyl-tRNA synthetase (MetRS) specifically binds its methionine substrate in an induced-fit mechanism, with methionine binding causing large rearrangements. Mutated MetRS able to efficiently aminoacylate the methioni...
- NMR Studies Reveal the Role of Biomembranes in Modulating Ligand Binding and Release by Intracellular Bile Acid Binding Proteins
[作者：Pedo, M; Lohr, F; D'Onofrio, M; Assfalg, M; Dotsch, V; Molinari, H,期刊：Journal of Molecular Biology, 页码：852-863 , 文章类型： Article，,卷期：2009年394-5]
- Bile acid molecules are transferred vectorially between basolateral and apical membranes of hepatocytes and enterocytes in the context of the enterohepatic circulation, a process regulating whole body lipid homeostasis. ...
- Solution Structure of Ectodomains of the Insulin Receptor Family: The Ectodomain of the Type 1 Insulin-Like Growth Factor Receptor Displays Asymmetry of Ligand Binding Accompanied by Limited Conformational Change
[作者：Whitten, AE; Smith, BJ; Menting, JG; Margetts, MB; McKern, NM; Lovrecz, GO; Adams, TE; Richards, K; Bentley, JD; Trewhella, J; Ward, CW; Lawrence, MC,期刊：Journal of Molecular Biology, 页码：878-892 , 文章类型： Article，,卷期：2009年394-5]
- The insulin receptor (IR) and the homologous Type 1 insulin-like growth factor receptor (IGF-1R) are cell-surface tyrosine kinase receptors that effect signaling within the respective pathways of glucose metabolism and n...
- Structure of IL-17A in Complex with a Potent, Fully Human Neutralizing Antibody
[作者：Gerhardt, S; Abbott, WM; Hargreaves, D; Pauptit, RA; Davies, RA; Needham, MRC; Langham, C; Barker, W; Aziz, A; Snow, MJ; Dawson, S; Welsh, F; Wilkinson, T; Vaugan, T; Beste, G; Bishop, S; Popovic, B; Rees, G; Sleeman, M; Tuske, SJ; Coales, SJ; Hamuro, Y; Russell, C,期刊：Journal of Molecular Biology, 页码：905-921 , 文章类型： Article，,卷期：2009年394-5]
- IL-17A is a pro-inflammatory cytokine produced by the newly identified Th17 subset of T-cells. We have isolated a human monoclonal antibody to IL-17A (CAT-2200) that can potently neutralize the effects of recombinant and...
- Posttranslational Modifications Affect the Interaction of S100 Proteins with Tumor Suppressor p53
[作者：van Dieck, J; Teufel, DP; Jaulent, AM; Fernandez-Fernandez, MR; Rutherford, TJ; Wyslouch-Cieszynska, A; Fersht, AR,期刊：Journal of Molecular Biology, 页码：922-930 , 文章类型： Article，,卷期：2009年394-5]
- Proteins of the S100 family bind to the intrinsically disordered transactivation domain (TAD; residues 1-57) and C-terminus (residues 293-393) of the tumor suppressor p53. Both regions provide sites that are subject to p...
- Structure and Function of the Oxidoreductase DsbA1 from Neisseria meningitidis
[作者：Vivian, JP; Scoullar, J; Rimmer, K; Bushell, SR; Beddoe, T; Wilce, MCJ; Byres, E; Boyle, TP; Doak, B; Simpson, JS; Graham, B; Heras, B; Kahler, CM; Rossjohn, J; Scanlon, MJ,期刊：Journal of Molecular Biology, 页码：931-943 , 文章类型： Article，,卷期：2009年394-5]
- Neisseria meningitidis encodes three DsbA oxidoreductases (NmDsbA1-NmDsbA3) that are vital for the oxidative folding of many membrane and secreted proteins, and these three enzymes are considered to exhibit different sub...
- The Structure of the N-Terminus of Kindlin-1: A Domain Important for alpha IIb beta 3 Integrin Activation
[作者：Goult, BT; Bouaouina, M; Harburger, DS; Bate, N; Patel, B; Anthis, NJ; Campbell, ID; Calderwood, DA; Barsukov, IL; Roberts, GC; Critchley, DR,期刊：Journal of Molecular Biology, 页码：944-956 , 文章类型： Article，,卷期：2009年394-5]
- The integrin family of heterodimeric cell adhesion molecules exists in both low- and high-affinity states, and integrin activation requires binding of the talin FERM (four-point-one, ezrin, radixin, moesin) domain to mem...
- Structural and Thermodynamic Characterization of Pre- and Postpolymerization States in the F4 Fimbrial Subunit FaeG
[作者：Van Molle, I; Moonens, K; Garcia-Pino, A; Buts, L; De Kerpel, M; Wyns, L; Bouckaert, J; De Greve, H,期刊：Journal of Molecular Biology, 页码：957-967 , 文章类型： Article，,卷期：2009年394-5]
- Enterotoxigenic Escherichia coli expressing F4 fimbriae are the major cause of porcine colibacillosis and are responsible for significant death and morbidity in neonatal and postweaned piglets. Via the chaperone-usher pa...
- Experimentally Approaching the Solvent-Accessible Surface Area of a Protein: Insights into the Acid Molten Globule of Bovine alpha-Lactalbumin
[作者：Craig, PO; Gomez, GE; Ureta, DB; Caramelo, JJ; Delfino, JM,期刊：Journal of Molecular Biology, 页码：982-993 , 文章类型： Article，,卷期：2009年394-5]
- Each conformational state of a protein is inextricably related to a defined extent of solvent exposure that plays a key role in protein folding and protein interactions. However, accurate measurement of the solvent-acces...
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