- Rising standards for tuberculosis drug development
[作者:Balganesh, TS; Alzari, PM; Cole, ST,期刊:Trends in Pharmacological Sciences, 页码:576-581 , 文章类型: Review,,卷期:2008年29-11]
Development of new drugs to treat tuberculosis (TB) faces even more constraints than the development of therapeutic agents for other diseases. This is due, in part, to intrinsic properties of the tubercle bacillus, su...
- G(12)/G(13)-mediated signalling in mammalian physiology and disease
[作者:Worzfeld, T; Wettschureck, N; Offermanns, S,期刊:Trends in Pharmacological Sciences, 页码:582-589 , 文章类型: Review,,卷期:2008年29-11]
The human genome encodes hundreds of G-protein-coupled receptors. Their intracellular effects, however, are mediated by only four families of heterotrimeric G proteins: G(s), G(i)/G(o), G(q)/G(11) and G(12)/G(13). Pro...
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