- Comparison of the effects of pioglitazone and metformin on hepatic and extra-hepatic insulin action in people with type 2 diabetes
[作者：Basu, R; Shah, P; Basu, A; Norby, B; Dicke, B; Chandramouli, V; Cohen, O; Landau, BR; Rizza, RA,期刊：Diabetes, 页码：24-31 , 文章类型： Article，,卷期：2008年57-1]
- OBJECTIVE-To determine mechanisms by which pioglitazone and metformin effect hepatic and extra-hepatic insulin action.RESEARCH DESIGN AND METHODS-Thirty-one subjects with type 2 diabetes were randomly assigned to pioglit...
- Defective lipid delivery modulates glucose tolerance and metabolic response to diet in apolipoprotein E-deficient mice
[作者：Hofmann, SM; Perez-Tilve, D; Greer, TM; Coburn, BA; Grant, E; Basford, JE; Tschop, MH; Hui, DY,期刊：Diabetes, 页码：5-12 , 文章类型： Article，,卷期：2008年57-1]
- OBJECTIVE-Apolipoprotein E (ApoE) regulates plasma lipid levels via modulation of lipolysis and serving as ligand for receptor-mediated clearance of triglyceride (TG)-rich lipoproteins. This study tested the impact of mo...
- Denervation and high-fat diet reduce insulin signaling in T-tubules in skeletal muscle of living mice
[作者：Lauritzen, HPMM; Ploug, T; Ai, H; Donsmark, M; Prats, C; Galbo, H,期刊：Diabetes, 页码：13-23 , 文章类型： Article，,卷期：2008年57-1]
- OBJECTIVE-Insulin stimulates muscle glucose transport by translocation of GLUT4 to sarcolemma and T-tubules. Despite muscle glucose uptake playing a major role in insulin resistance and type 2 diabetes, the temporal and ...
- Resistance to diet-induced obesity and improved insulin sensitivity in mice with a regulator of g protein signaling-insensitive G184S Gnai2 allele
[作者：Huang, XY; Charbeneau, RA; Fu, Y; Kaur, K; Gerin, I; MacDougald, OA; Neubig, RR,期刊：Diabetes, 页码：77-85 , 文章类型： Article，,卷期：2008年57-1]
- OBJECTIVE-Guanine nucleotide binding protein (G protein)mediated signaling plays major roles in endocrine/metabolic function. Regulators of G protein signaling (RGSs, or RGS proteins) are responsible for the subsecond tu...
- Low physical activity accentuates the effect of the FTO rs9939609 polymorphism on body fat accumulation
[作者：Andreasen, CH; Stender-Petersen, KL; Mogensen, MS; Torekov, SS; Wegner, L; Andersen, G; Nielsen, AL; Albrechtsen, A; Borch-Johnsen, K; Rasmussen, SS; Clausen, JO; Sandbaek, A; Lauritzen, T; Hansen, L; Jorgensen, T; Pedersen, O; Hansen, T,期刊：Diabetes, 页码：95-101 , 文章类型： Article，,卷期：2008年57-1]
- OBJECTIVE-Three independent studies have shown that variation in the fat mass and obesity-associated (FTO) gene associates with BMI and obesity. In the present study, the effect of FTO variation on metabolic traits inclu...
- Functional waning of naturally occurring CD4(+) regulatory T-Cells contributes to the onset of autoimmune diabetes
[作者：Tritt, M; Sgouroudis, E; d'Hennezel, E; Albanese, A; Piccirillo, CA,期刊：Diabetes, 页码：113-123 , 文章类型： Article，,卷期：2008年57-1]
- OBJECTIVE-In this study, we asked whether a possible quantitative or qualitative deficiency in naturally occurring Foxp3(+)CD4(+) regulatory T-cells (nT(reg)), which display potent inhibitory effects on T-cell functions ...
- The role of nitric oxide and the unfolded protein response in cytokine-induced beta-cell death
[作者：Chambers, KT; Unverferth, JA; Weber, SM; Wek, RC; Urano, F; Corbett, JA,期刊：Diabetes, 页码：124-132 , 文章类型： Article，,卷期：2008年57-1]
- OBJECTEVE-The unfolded protein response (UPR) is a conserved cellular response designed to alleviate damage and promote survival of cells experiencing stress; however, prolonged UPR activation can result in apoptotic cel...
- Long-range enhancers are required to maintain expression of the autoantigen islet-specific glucose-6-phosphatase catalytic subunit-related protein in adult mouse islets in vivo
[作者：Wang, Y; Flemming, BP; Martin, CC; Allen, SR; Walters, J; Oeser, JK; Hutton, JC; O'Brien, RM,期刊：Diabetes, 页码：133-141 , 文章类型： Article，,卷期：2008年57-1]
- OBJECTrVE-Islet-specific glucose-6-phosphatase catalytic subunit-related protein (IGRP) is selectively expressed in islet P-cells and is a major autoantigen in both mouse and human type 1 diabetes. This study describes t...
- Electronegative LDL impairs vascular endothelial cell integrity in diabetes by disrupting fibroblast growth factor 2 (FGF2) autoregulation
[作者：Lu, J; Jiang, W; Yang, JH; Chang, PY; Walterscheid, JP; Chen, HH; Marcelli, M; Tang, D; Lee, YT; Liao, WSL; Yang, CY; Chen, CH,期刊：Diabetes, 页码：158-166 , 文章类型： Article，,卷期：2008年57-1]
- OBJECTIVE-L5, a circulating electronegative LDL identified in patients with hypercholesterolemia or type 2 diabetes, induces endothelial cell (EC) apoptosis by suppressing fibroblast growth factor (FGF)2 expression. FGF2...
- Endothelial dysfunction and C-reactive protein are risk factors for diabetes in essential hypertension
[作者：Perticone, F; Maio, R; Sciacqua, A; Andreozzi, F; Iemma, G; Perticone, M; Zoccali, C; Sesti, G,期刊：Diabetes, 页码：167-171 , 文章类型： Article，,卷期：2008年57-1]
- OBJECTIVE-Type 2 diabetes and essential hypertension are major risk factors for cardiovascular diseases. Endothelial dysfunction is an early step in the development of atherosclerosis and has been demonstrated in hyperte...
- Expression of N-G,N-G-dimethylarginine dimethylaminohydrolase and protein arginine N-methyltransferase isoforms in diabetic rat kidney - Effects of angiotensin II receptor blockers
[作者：Onozato, ML; Tojo, A; Leiper, J; Fujita, T; Palm, F; Wilcox, CS,期刊：Diabetes, 页码：172-180 , 文章类型： Article，,卷期：2008年57-1]
- OBJECTIVE-The nitric oxide (NO) synthase inhibitor asymmetric dimethylarginine (ADMA) is generated by protein arginine N-methyltransferase (PRMT)-1 and is metabolized by N-G,N-G-dimethylarginine dimethylaminohydrolase (D...
- Partial pancreatectomy in adult humans does not provoke beta-cell regeneration
[作者：Menge, BA; Tannapfel, A; Belyaev, O; Drescher, R; Muller, C; Uhl, W; Schmidt, WE; Meier, JJ,期刊：Diabetes, 页码：142-149 , 文章类型： Article，,卷期：2008年57-1]
- OBJECTIVE-beta-Cell regeneration has been proposed as a possible treatment for diabetes, but the capacity for new beta-cell formation in humans is yet unclear. In young rats, partial pancreatectomy prompts new beta-cell ...
- MT1-MMP expression in first-trimester placental tissue is upregulated in type 1 diabetes as a result of elevated insulin and tumor necrosis factor-alpha levels
[作者：Hiden, U; Glitzner, E; Ivanisevic, M; Djelmis, J; Wadsack, C; Lang, U; Desoye, G,期刊：Diabetes, 页码：150-157 , 文章类型： Article，,卷期：2008年57-1]
- OBJECTIVE-In pregestational diabetes, the placenta at term of gestation is characterized by various structural and functional changes. Whether similar alterations occur in the first trimester has remained elusive. Placen...
- Stromal cell-derived factor-1/CXCL12 stimulates chemorepulsion of NOD/LtJ T-Cell adhesion to islet microvascular endothelium
[作者：Sharp, CA; Huang, M; Glawe, J; Patrick, DR; Pardue, S; Barlow, SC; Kevil, CG,期刊：Diabetes, 页码：102-112 , 文章类型： Article，,卷期：2008年57-1]
- OBJECTIVE-Diabetogenic T-cell recruitment into pancreatic islets faciltates beta-cell destruction during autoimmune diabetes, yet specific mechanisms governing this process are poorly understood. The chemokine stromal ce...
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