- Elevated toll-like receptor 4 expression and signaling in muscle from insulin-resistant subjects
[作者：Reyna, SM; Ghosh, S; Tantiwong, P; Meka, CSR; Eagan, P; Jenkinson, CP; Cersosimo, E; DeFronzo, RA; Coletta, DK; Sriwijitkamol, A; Musi, N,期刊：Diabetes, 页码：2595-2602 , 文章类型： Article，,卷期：2008年57-10]
- OBJECTIVE-Tall-like receptor (TLR)4 has been implicated in the pathogenesis of free fatty acid (FFA)-induced insulin resistance by activating inflammatory pathways, including inhibitor of kappa B (I kappa B)/nuclear fact...
- The "perfect storm" for type 1 diabetes - the complex interplay between intestinal microbiota, gut permeability, and mucosal immunity
[作者：Vaarala, O; Atkinson, MA; Neu, J,期刊：Diabetes, 页码：2555-2562 , 文章类型： Article，,卷期：2008年57-10]
- It is often stated that type 1 diabetes results from a complex interplay between varying degrees of genetic susceptibility and environmental factors. While agreeing with this principal, our desire is that this Perspectiv...
- Metabolism-independent sugar sensing in central orexin neurons
[作者：Gonzalez, JA; Jensen, LT; Fugger, L; Burdakov, D,期刊：Diabetes, 页码：2569-2576 , 文章类型： Article，,卷期：2008年57-10]
- OBJECTIVE-Glucose sensing by specialized neurons of the hypothalamus is vital for normal energy balance. In many glucose-activated neurons, glucose metabolism is considered a critical step in glucose sensing, but whether...
- Brain glucagon-like peptide-1 regulates arterial blood flow, heart rate, and insulin sensitivity
[作者：Cabou, C; Campistron, G; Marsollier, N; Leloup, C; Cruciani-Guglielmacci, C; Penicaud, L; Drucker, DJ; Magnan, C; Burcelin, R,期刊：Diabetes, 页码：2577-2587 , 文章类型： Article，,卷期：2008年57-10]
- OBJECTIVE-To ascertain the importance and mechanisms underlying the role of brain glucagon-like peptide (GLP)-1 in the control of metabolic and cardiovascular function. GLP-1 is a gut hormone secreted in response to oral...
- Role of central nervous system glueagon-like peptide-1 reeeptors in enterie glueose sensing
[作者：Knauf, C; Cani, PD; Kim, DH; Iglesias, MA; Chabo, C; Waget, A; Colom, A; Rastrelli, S; Delzenne, NM; Drucker, DJ; Seeley, RJ; Burcelin, R,期刊：Diabetes, 页码：2603-2612 , 文章类型： Article，,卷期：2008年57-10]
- OBJECTIVE-Ingested glucose is detected by specialized sensors in the enteric/hepatoportal vein, which send neural signals to the brain, which in turn regulates key peripheral tissues. Hence, impairment in the control of ...
- Cerebral blood flow and cerebral edema in rats with diabetic ketoacidosis
[作者：Yuen, N; Anderson, SE; Glaser, N; Tancredi, DJ; O'Donnell, ME,期刊：Diabetes, 页码：2588-2594 , 文章类型： Article，,卷期：2008年57-10]
- OBJECTIVE-Cerebral edema (CE) is a potentially life-threatening complication of diabetic ketoacidosis (DKA) in children. Osmotic fluctuations during DKA treatment have been considered responsible, but recent data instead...
- Physical activity and insulin sensitivity - the RISC Study
[作者：Balkau, B; Mhamdi, L; Oppert, JM; Nolan, J; Golay, A; Porcellati, F; Laakso, M; Ferrannini, E,期刊：Diabetes, 页码：2613-2618 , 文章类型： Article，,卷期：2008年57-10]
- OBJECTIVE-Physical activity is a modifiable risk factor for type 2 diabetes, partly through its action on insulin sensitivity. We report the relation between insulin sensitivity and physical activity measured by accelero...
- Transforming growth factor-beta suppresses the activation of CD8(+) T-Cells when naive but promotes their survival and function once antigen experienced - a two-faced once antigen autoimmunity
[作者：Filippi, CM; Juedes, AE; Oldham, JE; Ling, E; Togher, L; Peng, YF; Flavell, RA; von Herrath, MG,期刊：Diabetes, 页码：2684-2692 , 文章类型： Article，,卷期：2008年57-10]
- OBJECTIVE-Transforming growth factor-beta (TGF-(beta) can exhibit strong immune suppression but has also been shown to promote T-cell growth. We investigated the differential effect of this cytokine on CD8(+) T-cells in ...
- Spontaneous diabetes in hemizygous human amylin transgenic mice that developed neither islet amyloid nor peripheral insulin resistance
[作者：Wong, WPS; Scott, DW; Chuang, CL; Zhang, SP; Liu, H; Ferreira, A; Saafi, EL; Choong, YS; Cooper, GJS,期刊：Diabetes, 页码：2737-2744 , 文章类型： Article，,卷期：2008年57-10]
- OBJECTIVES-We sought to 1) Determine whether soluble-misfolded amylin or insoluble-fibrillar amylin may cause or result from diabetes in human amylin transgenic mice and 2) determine the role, if any, that insulin resist...
- Baseline serum 25-hydroxy vitamin D is predictive of future glycemic status and insulin resistance - The Medical Research Council Ely Prospective Study 1990-2000
[作者：Forouhi, NG; Luan, J; Cooper, A; Boucher, BJ; Wareham, NJ,期刊：Diabetes, 页码：2619-2625 , 文章类型： Article，,卷期：2008年57-10]
- OBJECTIVE-Accumulating epidemiological evidence suggests that hypovitaminosis D may be associated with type 2 diabetes and related metabolic risks. However, prospective data using the biomarker serum 25-hydroxyvitamin D ...
- Hepatocyte growth factor enhances engraftment and function of nonhuman primate islets
[作者：Fiaschi-Taesch, NM; Berman, DM; Sicari, BM; Takane, KK; Garcia-Ocana, A; Ricordi, C; Kenyon, NS; Steward, AF,期刊：Diabetes, 页码：2745-2754 , 文章类型： Article，,卷期：2008年57-10]
- OBJECTIVE-Adenoviral delivery of hepatocyte growth factor (HGF) to rodent islets improves islet graft survival and function, markedly reducing the number of islets required to achieve glucose control. Here, we asked whet...
- Mechanism of oxidative DNA damage in diabetes - tuberin inactivation and downregulation of DNA repair enzyme 8-oxo-7,8-dihydro-2'-deoxyguanosine-DNA glycosylase
[作者：Simone, S; Gorin, Y; Velagapudi, C; Abboud, HE; Habib, SL,期刊：Diabetes, 页码：2626-2636 , 文章类型： Article，,卷期：2008年57-10]
- OBJECTIVE-To investigate potential mechanisms of oxidative DNA damage in a rat model of type 1 diabetes and in murine proximal tubular epithelial cells and primary culture of rat proximal tubular epithelial cells.RESEARC...
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