- Highly potent and specific siRNAs against E6 or E7 genes of HPV16-or HPV18-infected cervical cancers
[作者:Chang, JTC; Kuo, TF; Chen, YJ; Chiu, CC; Lu, YC; Li, HF; Shen, CR; Cheng, AJ,期刊:Cancer gene therapy, 页码:827-836 , 文章类型: Article,,卷期:2010年17-12]
- Infection with high-risk types (type 16 or type 18) of human papillomaviruses (HPVs) increases a patient's risk of cervical cancer. Given the importance of the cervix and the severe side effects resulting from traditiona...
- A phase I clinical trial of thymidine kinase-based gene therapy in advanced hepatocellular carcinoma
[作者:Sangro, B; Mazzolini, G; Ruiz, M; Ruiz, J; Quiroga, J; Herrero, I; Qian, C; Benito, A; Larrache, J; Olague, C; Boan, J; Penuelas, I; Sadaba, B; Prieto, J,期刊:Cancer gene therapy, 页码:837-843 , 文章类型: Article,,卷期:2010年17-12]
- The aim of this phase I clinical trial was to assess the feasibility and safety of intratumoral administration of a first-generation adenoviral vector encoding herpes simplex virus thymidine kinase (HSV-TK) gene (Ad.TK) ...
- Enhanced tumor suppression in vitro and in vivo by co-expression of survivin-specific siRNA and wild-type p53 protein
[作者:Shao, Y; Liu, Y; Shao, C; Hu, J; Li, X; Li, F; Zhang, L; Zhao, D; Sun, L; Zhao, X; Kopecko, DJ; Kalvakolanu, DV; Li, Y; Xu, DQ,期刊:Cancer gene therapy, 页码:844-854 , 文章类型: Article,,卷期:2010年17-12]
- The development of malignant prostate cancer involves multiple genetic alterations. For example, alterations in both survivin and p53 are reported to have crucial roles in prostate cancer progression. However, little is ...
- Blood outgrowth endothelial cell-based systemic delivery of antiangiogenic gene therapy for solid tumors
[作者:Bodempudi, V; Ohlfest, JR; Terai, K; Zamora, EA; Vogel, RI; Gupta, K; Hebbel, RP; Dudek, AZ,期刊:Cancer gene therapy, 页码:855-863 , 文章类型: Article,,卷期:2010年17-12]
- Endothelial cells and endothelial cell precursors encoding a therapeutic gene have induced antitumor responses in preclinical models. Culture of peripheral blood provides a rich supply of autologous, highly proliferative...
- Plasmid injection and application of electric pulses alter endogenous mRNA and protein expression in B16.F10 mouse melanomas
[作者:Heller, LC; Cruz, YL; Ferraro, B; Yang, H; Heller, R,期刊:Cancer gene therapy, 页码:864-871 , 文章类型: Article,,卷期:2010年17-12]
- The application of electric pulses to tissues causes cell membrane destabilization, allowing exogenous molecules to enter the cells. This delivery technique can be used for plasmid gene therapy. Reporter gene expression ...
- Resveratrol-induced p53-independent apoptosis of human nasopharyngeal carcinoma cells is correlated with the downregulation of Delta Np63
[作者:Chow, SE; Wang, JS; Chuang, SF; Chang, YL; Chu, WK; Chen, WS; Chen, YW,期刊:Cancer gene therapy, 页码:872-882 , 文章类型: Article,,卷期:2010年17-12]
Delta Np63, the N-terminal truncated isoform of p63, has been found to be overexpressed in several human epithelial cancers, including nasopharyngeal carcinomas (NPCs), suggesting a function in carcinogenesis. Trans-r...
- Arming a replicating adenovirus with osteoprotegerin reduces the tumor burden in a murine model of osteolytic bone metastases of breast cancer
[作者:Cody, JJ; Rivera, AA; Lyons, GR; Yang, SW; Wang, M; Sarver, DB; Wang, D; Selander, KS; Kuo, HC; Meleth, S; Feng, X; Siegall, GP; Douglas, JT,期刊:Cancer gene therapy, 页码:893-905 , 文章类型: Article,,卷期:2010年17-12]
- Most patients with advanced breast cancer develop osteolytic bone metastases, which have numerous complications. Because current therapies are not curative, new treatments are needed. Conditionally replicating adenovirus...
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