- Targeting MMP-9, uPAR, and cathepsin B inhibits invasion, migration and activates apoptosis in prostate cancer cells
[作者:Nalla, AK; Gorantla, B; Gondi, CS; Lakka, SS; Rao, JS,期刊:Cancer gene therapy, 页码:599-613 , 文章类型: Article,,卷期:2010年17-9]
- Prostate cancer is one of the most commonly diagnosed cancers and the second leading cause of cancer deaths in Americans. The high mortality rate is mainly attributed to the invasiveness and metastasis of advanced prosta...
- Enhanced efficiency of prodrug activation therapy by tumor-selective replicating retrovirus vectors armed with the Escherichia coli purine nucleoside phosphorylase gene
[作者:Tai, CK; Wang, W; Lai, YH; Logg, CR; Parker, WB; Li, YF; Hong, JS; Sorscher, EJ; Chen, TC; Kasahara, N,期刊:Cancer gene therapy, 页码:614-623 , 文章类型: Article,,卷期:2010年17-9]
- Gene transfer of the Escherichia coli purine nucleoside phosphorylase (PNP) results in potent cytotoxicity after administration of the prodrug fludarabine phosphate (F-araAMP). Here, we have tested whether application of...
- Knockdown of Efp by DNA-modified small interfering RNA inhibits breast cancer cell proliferation and in vivo tumor growth
[作者:Ueyama, K; Ikeda, K; Sato, W; Nakasato, N; Horie-Inoue, K; Takeda, S; Inoue, S,期刊:Cancer gene therapy, 页码:624-632 , 文章类型: Article,,卷期:2010年17-9]
- The estrogen-responsive gene Efp promotes the growth of breast cancer cells by stimulating the degradation of a negative cell-cycle regulator, 14-3-3 sigma, and is hence considered a suitable molecular target for breast ...
- Synergistic growth inhibition of anaplastic large cell lymphoma cells by combining cellular ALK gene silencing and a low dose of the kinase inhibitor U0126
[作者:Ito, M; Zhao, N; Zeng, Z; Chang, CC; Zu, Y,期刊:Cancer gene therapy, 页码:633-644 , 文章类型: Article,,卷期:2010年17-9]
- Abnormal expression of anaplastic lymphoma kinase (ALK) gene is an important pathogenic factor for anaplastic large cell lymphoma (ALCL). To study the function of ALK, an inducible short hairpin RNA (shRNA) system was st...
- Antigen quality determines the efficiency of antitumor immune responses generated in the absence of regulatory T cells
[作者:Bergot, AS; Durgeau, A; Levacher, B; Colombo, BM; Cohen, JL; Klatzmann, D,期刊:Cancer gene therapy, 页码:645-654 , 文章类型: Article,,卷期:2010年17-9]
- The observation that depletion or inhibition of regulatory T cells (Tregs) unleashes efficient antitumor effector immune responses that can lead to tumor eradication in mice has opened new perspectives for the developmen...
- Targeting HSV-1 virions for specific binding to epidermal growth factor receptor-vIII-bearing tumor cells
[作者:Grandi, P; Fernandez, J; Szentirmai, O; Carter, R; Gianni, D; Sena-Esteves, M; Breakefield, XO,期刊:Cancer gene therapy, 页码:655-663 , 文章类型: Article,,卷期:2010年17-9]
- Oncolytic herpes simplex virus (HSV) vectors have been used in early phase human clinical trials as a therapy for recurrent malignant glioblastoma. This treatment proved safe but limited improvements in patient survival ...
- Embryonic stem cell (ESC)-mediated transgene delivery induces growth suppression, apoptosis and radiosensitization, and overcomes temozolomide resistance in malignant gliomas
[作者:Germano, IM; Emdad, L; Qadeer, ZA; Binello, E; Uzzaman, M,期刊:Cancer gene therapy, 页码:664-674 , 文章类型: Article,,卷期:2010年17-9]
High-grade gliomas are among the most lethal of all cancers. Despite considerable advances in multimodality treatment, including surgery, radiotherapy and chemotherapy, the overall prognosis for patients with this dis...
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