- Conditional inactivation of Has2 reveals a crucial role for hyaluronan in skeletal growth, patterning, chondrocyte maturation and joint formation in the developing limb
[作者:Matsumoto, K; Li, YC; Jakuba, C; Sugiyama, Y; Sayo, T; Okuno, M; Dealy, CN; Toole, BP; Takeda, J; Yamaguchi, Y; Kosher, RA,期刊:Development, 页码:2825-2835 , 文章类型: Article,,卷期:2009年136-16]
- The glycosaminoglycan hyaluronan ( HA) is a structural component of extracellular matrices and also interacts with cell surface receptors to directly influence cell behavior. To explore functions of HA in limb skeletal d...
- Wash functions downstream of Rho and links linear and branched actin nucleation factors
[作者:Liu, R; Abreu-Blanco, MT; Barry, KC; Linardopoulou, EV; Osborn, GE; Parkhurst, SM,期刊:Development, 页码:2849-2860 , 文章类型: Article,,卷期:2009年136-16]
- Wiskott-Aldrich Syndrome (WAS) family proteins are Arp2/3 activators that mediate the branched-actin network formation required for cytoskeletal remodeling, intracellular transport and cell locomotion. Wasp and Scar/WAVE...
- Auxin transport routes in plant development
[作者:Petrasek, J; Friml, J,期刊:Development, 页码:2675-2688 , 文章类型: Review,,卷期:2009年136-16]
- The differential distribution of the plant signaling molecule auxin is required for many aspects of plant development. Local auxin maxima and gradients arise as a result of local auxin metabolism and, predominantly, from...
- beta 1 integrins are required for normal CNS myelination and promote AKT-dependent myelin outgrowth
[作者:Barros, CS; Nguyen, T; Spencer, KSR; Nishiyama, A; Colognato, H; Muller, U,期刊:Development, 页码:2717-2724 , 文章类型: Article,,卷期:2009年136-16]
- Oligodendrocytes in the central nervous system (CNS) produce myelin sheaths that insulate axons to ensure fast propagation of action potentials. beta 1 integrins regulate the myelination of peripheral nerves, but their f...
- UNC-83 is a nuclear-specific cargo adaptor for kinesin-1-mediated nuclear migration
[作者:Meyerzon, M; Fridolfsson, HN; Ly, N; McNally, FJ; Starr, DA,期刊:Development, 页码:2725-2733 , 文章类型: Article,,卷期:2009年136-16]
- Intracellular nuclear migration is essential for many cellular events including fertilization, establishment of polarity, division and differentiation. How nuclei migrate is not understood at the molecular level. The C. ...
- The NK-2 class homeodomain factor CEH-51 and the T-box factor TBX-35 have overlapping function in C-elegans mesoderm development
[作者:Broitman-Maduro, G; Owraghi, M; Hung, WWK; Kuntz, S; Sternberg, PW; Maduro, MF,期刊:Development, 页码:2735-2746 , 文章类型: Article,,卷期:2009年136-16]
- The C. elegans MS blastomere, born at the 7-cell stage of embryogenesis, generates primarily mesodermal cell types, including pharynx cells, body muscles and coelomocytes. A presumptive null mutation in the T-box factor ...
- Regulation of bone formation and remodeling by G-protein-coupled receptor 48
[作者:Luo, J; Zhou, W; Zhou, X; Li, DL; Weng, JS; Yi, ZF; Cho, SG; Li, CH; Yi, TF; Wu, XS; Li, XY; de Crombrugghe, B; Hook, M; Liu, MY,期刊:Development, 页码:2747-2756 , 文章类型: Article,,卷期:2009年136-16]
- G-protein-coupled receptor ( GPCR) 48 (Gpr48; Lgr4), a newly discovered member of the glycoprotein hormone receptor subfamily of GPCRs, is an orphan GPCR of unknown function. Using a knockout mouse model, we have charact...
- The Integrator subunits function in hematopoiesis by modulating Smad/BMP signaling
[作者:Tao, SJ; Cai, Y; Sampath, K,期刊:Development, 页码:2757-2765 , 文章类型: Article,,卷期:2009年136-16]
- Hematopoiesis, the dynamic process of blood cell development, is regulated by the activity of the bone morphogenetic protein (BMP) signaling pathway and by many transcription factors. However, the molecules and mechanism...
- The apicobasal polarity kinase aPKC functions as a nuclear determinant and regulates cell proliferation and fate during Xenopus primary neurogenesis
[作者:Sabherwal, N; Tsutsui, A; Hodge, S; Wei, J; Chalmers, AD; Papalopulu, N,期刊:Development, 页码:2767-2777 , 文章类型: Article,,卷期:2009年136-16]
- During neurogenesis in Xenopus, apicobasally polarised superficial and non-polar deep cells take up different fates: deep cells become primary neurons while superficial cells stay as progenitors. It is not known whether ...
- beta 1 integrins are required for the invasion of the caecum and proximal hindgut by enteric neural crest cells
[作者:Breau, MA; Dahmani, A; Broders-Bondon, F; Thiery, JP; Dufour, S,期刊:Development, 页码:2791-2801 , 文章类型: Article,,卷期:2009年136-16]
- Integrins are the major adhesive receptors for extracellular matrix and have various roles in development. To determine their role in cell migration, the gene encoding the beta 1 integrin subunit (Itgb1) was conditionall...
- Rab5-mediated endocytosis of activin is not required for gene activation or long-range signalling in Xenopus
[作者:Hagemann, AI; Xu, X; Nentwich, O; Hyvonen, M; Smith, JC,期刊:Development, 页码:2803-2813 , 文章类型: Article,,卷期:2009年136-16]
- Morphogen gradients provide positional cues for cell fate specification and tissue patterning during embryonic development. One important aspect of morphogen function, the mechanism by which long-range signalling occurs,...
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