Gelatin is a non-immunogenic and degradable biopolymer, which is widely applied in the biomedical field e. g. for drug capsules or as absorbable hemostats. However, gelatin materials present limited and hardly reproducib...
Polycarbonate terpolymers consisting of desaminotyrosyl-tyrosine alkyl esters (DTR), desaminotyrosyl-tyrosine (DT), and low molecular weight blocks of poly(ethylene glycol) (PEG) are a new class of polymers that have goo...
In contemporary tissue engineering there is a need for drug delivery approaches that offer controllable release kinetics from common surgical devices, particularly at healing tissue interfaces. We describe a generally ap...
Tissue-engineered nanofibrous matrices can potentially serve as an implantable scaffold for the reconstruction of damaged or lost tissue by regulating cell proliferation, organization, and function. In this study, we dev...
Nanocomposite scaffolds of bioactive glass foams containing tailor made rare earth oxide (i.e. nanoceria) additives were demonstrated to enhance the production of collagen by HMSCs (Human Mesenchymal Stem Cells) compared...
Hydrogel systems with inducible variations in mechanical and chemical properties are of interest to many aspects of tissue engineering. Substrate-tethered hydrogel films, fabricated by copolymerization of hydroxyethylacr...
Three dimensional microstructured scaffolds with precisely defined architectures have many promising features for tissue engineering applications, such as controllable porosity, optimal mechanical strength, and adjustabl...
The regeneration of bone lost due to disease and trauma as well as the bonding of bone to biomedical implants present significant challenges to the field of biomaterials. Increasing evidence for the benefit of strontium ...
This study investigated the potential use of stem cell-synthesized extracellular matrix (ECM) as a bone graft replacement therapy. ECM was synthesized by both mesenchymal stem cells (MSCs) and amniotic fluid stem cells (...
Bone grafts are commonly used to regenerate bone in defect sites resulting from disease or trauma but there is clinical need for artificial materials that will be readily available and reduce pain and recovery time for t...
Tissue engineering of various musculoskeletal or cardiovascular tissues requires scaffolds with controllable mechanical anisotropy. However, native tissues also exhibit significant inhomogeneity in their mechanical prope...
Engineering oral tissues as a multidisciplinary approach to build complex structures such as bone, teeth or soft dental tissues remains a challenging endeavor which will also require significant additional development of...
Progress made in basic research in the last decades led to a tremendous increase in quality of clinically appliedbone substitutematerials (polymers, ceramics and composites). The desired biological performance of these m...
The progress in the development of magnetic nanoparticle based therapies for various biomedical applications is reviewed here. Most significantly, magnetic nanoparticles have been widely used in drug delivery and hyperth...
Our laboratory developed "cell sheet engineering", which has been applied to regenerative medicine. However, the applications are restricted to the transplants of single-, double-, and triple-layered cell sheets, because...