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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共18条记录   Spherical mesoporous silica nanoparticles for loading and release of the poorly water-soluble drug telmisartan [作者：Zhang, YZ; Zhi, ZZ; Jiang, TY; Zhang, JH; Wang, ZY; Wang, SL,期刊：Journal of controlled release, 页码：257-263 , 文章类型： Article，,卷期：2010年145-3] The purpose of this study was to develop mesoporous silica nanoparticles (MSNs) loaded with a poorly water-soluble drug, intended to be orally administered, able to improve the dissolution rate and enhance the drug loadi... MMPs-responsive release of DNA from electrospun nanofibrous matrix for local gene therapy: In vitro and in vivo evaluation [作者：Kim, HS; Yoo, HS,期刊：Journal of controlled release, 页码：264-271 , 文章类型： Article，,卷期：2010年145-3] DNA-incorporated nanofibrous matrix was fabricated to control release of DNA in response to high concentration of MMPs such as diabetic ulcers. Nanofibrous matrix was electrospun employing amine groups-functionalized blo... Delivery of therapeutic shRNA and siRNA by Tat fusion peptide targeting bcr-abl fusion gene in Chronic Myeloid Leukemia cells [作者：Arthanari, Y; Pluen, A; Rajendran, R; Aojula, H; Demonacos, C,期刊：Journal of controlled release, 页码：272-280 , 文章类型： Article，,卷期：2010年145-3] Gene silencing by RNA interference (RNAi) is a promising therapeutic approach for a wide variety of diseases for which the biological cause is known. The main challenge remains the ineffective RNAi delivery inside the ce... Prolonged gene silencing by combining siRNA nanogels and photochemical internalization [作者：Raemdonck, K; Naeye, B; Hogset, A; Demeester, J; De Smedt, SC,期刊：Journal of controlled release, 页码：281-288 , 文章类型： Article，,卷期：2010年145-3] Small interfering RNAs (siRNAs) show potential for the treatment of a wide variety of pathologies with a known genetic origin through sequence-specific gene silencing. However, siRNAs do not have favorable drug-like prop... Intracellular FRET analysis of lipid/DNA complexes using flow cytometry and fluorescence imaging techniques [作者：Schneider, S; Lenz, D; Holzer, M; Palme, K; Suss, R,期刊：Journal of controlled release, 页码：289-296 , 文章类型： Article，,卷期：2010年145-3] Gene therapy is a promising therapeutic concept for a large number of incurable diseases. Lipid/DNA complexes (lipoplexes) are used to deliver genes into cells. However, while large efforts have been made to investigate ... Topical and intravitreous administration of cationic nanoemulsions to deliver antisense oligonucleotides directed towards VEGF KDR receptors to the eye [作者：Hagigit, T; Abdulrazik, M; Orucov, F; Valamanesh, F; Lambert, M; Lambert, G; Behar-Cohen, F; Benita, S,期刊：Journal of controlled release, 页码：297-305 , 文章类型： Article，,卷期：2010年145-3] Antisense oligonucleotides (ODNs) specific for VEGFR-2-(17 MER) and inhibiting HUVEC proliferation in-vitro were screened. One efficient sequence was selected and incorporated in different types of nanoemulsions the pote... PEGylation markedly enhances the in vivo potency of recombinant human non-glycosylated erythropoietin: A comparison with glycosylated erythropoietin [作者：Wang, YJ; Hao, SJ; Liu, YD; Hu, T; Zhang, GF; Zhang, XA; Qi, QS; Ma, GH; Su, ZG,期刊：Journal of controlled release, 页码：306-313 , 文章类型： Article，,卷期：2010年145-3] Recombinant human non-glycosylated erythropoietin (rh-ngEpo) expressed in E. coil was attached to polyethylene glycol (PEG) chains with different sizes and structures. The pharmacokinetic properties and in vivo potency o... Drug release coating for reduced tissue reaction to implanted neuroprostheses [作者：Park, K,期刊：Journal of controlled release, 页码：177-177 , 文章类型： Editorial Material，,卷期：2010年145-3] Stealth nanoparticles: High density but sheddable PEG is a key for tumor targeting [作者：Li, SD; Huang, L,期刊：Journal of controlled release, 页码：178-181 , 文章类型： Editorial Material，,卷期：2010年145-3] Endocytosis of nanomedicines [作者：Sahay, G; Alakhova, DY; Kabanov, AV,期刊：Journal of controlled release, 页码：182-195 , 文章类型： Review，,卷期：2010年145-3] Novel nanomaterials are being developed to improve diagnosis and therapy of diseases through effective delivery of drugs, biopharmaceutical molecules and imaging agents to target cells in disease sites. Such diagnostic a... Controlled release nanoparticle-embedded coatings reduce the tissue reaction to neuroprostheses [作者：Mercanzini, A; Reddy, ST; Velluto, D; Colin, P; Maillard, A; Bensadoun, JC; Hubbell, JA; Renaud, P,期刊：Journal of controlled release, 页码：196-202 , 文章类型： Article，,卷期：2010年145-3] Controlled release coatings were developed for neuroprostheses with the aim of combating the tissue reaction following implantation in the brain. The coatings consist of poly(propylene sulfide) drug-eluting nanoparticles... Non-invasive iontophoretic delivery of enzymatically active ribonuclease A (13.6 kDa) across intact porcine and human skins [作者：Dubey, S; Kalia, YN,期刊：Journal of controlled release, 页码：203-209 , 文章类型： Article，,卷期：2010年145-3] The purpose of the study was to demonstrate the feasibility of using transdermal iontophoresis to deliver a functional protein, ribonuclease A (RNAse; 13.6 kDa), non-invasively across the skin. Iontophoretic transport ex... Reduction in inflammation in the footpad of carrageenan treated mice following the topical administration of anti-TNF molecules formulated in a micro-emulsion [作者：Himes, R; Lee, S; McMenigall, K; Russell-Jones, GJ,期刊：Journal of controlled release, 页码：210-213 , 文章类型： Article，,卷期：2010年145-3] Water-in-oil micro-emulsions (ME) have been shown to have the ability to deliver water-soluble peptides and proteins into the skin. Topical administration of these formulations represents an ideal means of device-free de... Bioavailability in vivo of naltrexone following transbuccal administration by an electronically-controlled intraoral device: A trial on pigs [作者：Campisi, G; Giannola, LI; Florena, AM; De Caro, V; Schumacher, A; Gottsche, T; Paderni, C; Wolff, A,期刊：Journal of controlled release, 页码：214-220 , 文章类型： Article，,卷期：2010年145-3] Naltrexone (NLX), an opioid antagonist, is widely used in the treatment of opiate addiction, alcoholism and smoking cessation. Its current peroral administration induces various adverse side effects and has limited effic... Sustained release of vancomycin from polyurethane scaffolds inhibits infection of bone wounds in a rat femoral segmental defect model [作者：Li, B; Brown, KV; Wenke, JC; Guelcher, SA,期刊：Journal of controlled release, 页码：221-230 , 文章类型： Article，,卷期：2010年145-3] Infection is a common complication in open fractures that compromises the healing of bone and can result in loss of limb or life. Currently, the clinical standard of care for treating contaminated open fractures comprise... Slow and sustained release of active cytokines from self-assembling peptide scaffolds [作者：Gelain, F; Unsworth, LD; Zhang, SG,期刊：Journal of controlled release, 页码：231-239 , 文章类型： Article，,卷期：2010年145-3] Controlling the cellular microenvironment is thought to be critical for the successful application of biomaterials for regenerative medicine strategies. Self-assembling peptides are proving to be a promising platform for...