- High-Mobility Group A1 Protein A New Coregulator of Peroxisome Proliferator-Activated Receptor-gamma-Mediated Transrepression in the Vasculature
[作者：Bloch, M; Prock, A; Paonessa, F; Benz, V; Bahr, IN; Herbst, L; Witt, H; Kappert, K; Spranger, J; Stawowy, P; Unger, T; Fusco, A; Sedding, D; Brunetti, A; Foryst-Ludwig, A; Kintscher, U,期刊：Circulation Research, 页码：394-U82 , 文章类型： Article，,卷期：2012年110-3]
- Rationale: The nuclear receptor peroxisome proliferator-activated receptor-gamma (PPAR gamma) is an important regulator of gene transcription in vascular cells and mediates the vascular protection observed with antidiabe...
- Polycomb Repressive Complex 2 Regulates Normal Development of the Mouse Heart
[作者：He, AB; Ma, Q; Cao, JJ; von Gise, A; Zhou, PZ; Xie, HF; Zhang, B; Hsing, M; Christodoulou, DC; Cahan, P; Daley, GQ; Kong, SW; Orkin, SH; Seidman, CE; Seidman, JG; Pu, WT,期刊：Circulation Research, 页码：406-U102 , 文章类型： Article，,卷期：2012年110-3]
- Rationale: Epigenetic marks are crucial for organogenesis, but their role in heart development is poorly understood. Polycomb repressive complex 2 (PRC2) trimethylates histone H3 at lysine 27, which establishes H3K27me3 ...
- Endosomal Actin Remodeling by Coronin-1A Controls Lipoprotein Uptake and Degradation in Macrophages
[作者：Holtta-Vuori, M; Vainio, S; Kauppi, M; Van Eck, M; Jokitalo, E; Ikonen, E,期刊：Circulation Research, 页码：450-455 , 文章类型： Article，,卷期：2012年110-3]
- Rationale: The actin cytoskeleton has been implicated in the processing of atherogenic lipoproteins in macrophages. However, the functional role of actin and the regulatory proteins involved are unknown. Objective: Coron...
- Thymosin Beta 4 Is Dispensable for Murine Cardiac Development and Function
[作者：Banerjee, I; Zhang, JL; Moore-Morris, T; Lange, S; Shen, T; Dalton, ND; Gu, YS; Peterson, KL; Evans, SM; Chen, J,期刊：Circulation Research, 页码：456-U188 , 文章类型： Article，,卷期：2012年110-3]
- Rationale: Thymosin beta 4 (T beta 4) is a 43-amino acid factor encoded by an X-linked gene. Recent studies have suggested that T beta 4 is a key factor in cardiac development, growth, disease, epicardial integrity, and ...
- Inhibition of CaMKII Phosphorylation of RyR2 Prevents Induction of Atrial Fibrillation in FKBP12.6 Knockout Mice
[作者：Li, N; Wang, TN; Wang, W; Cutler, MJ; Wang, QL; Voigt, N; Rosenbaum, DS; Dobrev, D; Wehrens, XHT,期刊：Circulation Research, 页码：465-U208 , 文章类型： Article，,卷期：2012年110-3]
- Rationale: Abnormal calcium release from sarcoplasmic reticulum (SR) is considered an important trigger of atrial fibrillation (AF). Whereas increased Ca2+/calmodulin-dependent protein kinase II (CaMKII) activity has bee...
- Vascular Bioactivation of Nitroglycerin Is Catalyzed by Cytosolic Aldehyde Dehydrogenase-2
[作者：Beretta, M; Wolkart, G; Schernthaner, M; Griesberger, M; Neubauer, R; Schmidt, K; Sacherer, M; Heinzel, FR; Kohlwein, SD; Mayer, B,期刊：Circulation Research, 页码：385-U52 , 文章类型： Article，,卷期：2012年110-3]
- Rationale: According to general view, aldehyde dehydrogenase-2 (ALDH2) catalyzes the high-affinity pathway of vascular nitroglycerin (GTN) bioactivation in smooth muscle mitochondria. Despite having wide implications to ...
- NR4A1 (Nur77) Deletion Polarizes Macrophages Toward an Inflammatory Phenotype and Increases Atherosclerosis
[作者：Hanna, RN; Shaked, I; Hubbeling, HG; Punt, JA; Wu, RP; Herrley, E; Zaugg, C; Pei, H; Geissmann, F; Ley, K; Hedrick, CC,期刊：Circulation Research, 页码：416-U127 , 文章类型： Article，,卷期：2012年110-3]
- Rationale: NR4A1 (Nur77) is a nuclear receptor that is expressed in macrophages and within atherosclerotic lesions, yet its function in atherosclerosis is unknown. Objective: Nur77 regulates the development of monocytes,...
- Bone Marrow-Specific Deficiency of Nuclear Receptor Nur77 Enhances Atherosclerosis
[作者：Hamers, AAJ; Vos, M; Rassam, F; Marinkovic, G; Kurakula, K; van Gorp, PJ; de Winther, MPJ; Gijbels, MJJ; de Waard, V; de Vries, CJM,期刊：Circulation Research, 页码：428-U147 , 文章类型： Article，,卷期：2012年110-3]
- Rationale: Nuclear receptor Nur77, also known as NR4A1, TR3, or NGFI-B, is expressed in human atherosclerotic lesions in macrophages, endothelial cells, T cells and smooth muscle cells. Macrophages play a critical role i...
- Integrin-Linked Kinase Regulates Vasomotor Function by Preventing Endothelial Nitric Oxide Synthase Uncoupling Role in Atherosclerosis
[作者：Herranz, B; Marquez, S; Guijarro, B; Aracil, E; Aicart-Ramos, C; Rodriguez-Crespo, I; Rodriguez-Puyol, M; Zaragoza, C; Saura, M,期刊：Circulation Research, 页码：439-449 , 文章类型： Article，,卷期：2012年110-3]
- Rationale: Atherosclerotic lesions develop in regions of disturbed flow, whereas laminar flow protects from atherogenesis; however, the mechanisms involved are not completely elucidated. Integrins are mechanosensors of s...
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