- Ceramide targets autophagosomes to mitochondria and induces lethal mitophagy
[作者:SENTELLE R DAVID; SENKAL CAN E; JIANG WENHUI; PONNUSAMY SURIYAN; GENCER SALIH; SELVAM SHANMUGAM PANNEER; RAMSHESH VENKAT K; PETERSON YURI K; LEMASTERS JOHN J; SZULC ZDZISLAW M; BIELAWSKI JACEK; OGRETMEN BESIM,期刊:NATURE CHEMICAL BIOLOGY, 页码:831-838 , 文章类型: Article,,卷期:2012年8-10]
- Mechanisms by which autophagy promotes cell survival or death are unclear. We provide evidence that C-18-pyridinium ceramide treatment or endogenous C-18-ceramide generation by ceramide synthase 1 (CerS1) expression medi...
- Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis
[作者:ANASTASIOU DIMITRIOS; YU YIMIN; ISRAELSEN WILLIAM J; JIANG JIANKANG; BOXER MATTHEW B; HONG BUM SOO; TEMPEL WOLFRAM; DIMOV SVETOSLAV; SHEN MIN; JHA ABHISHEK; YANG HUA; MATTAINI KATHERINE R; METALLO CHRISTIAN M; FISKE BRIAN P; COURTNEY KEVIN D; MALSTROM SCOTT; KHAN TAHSIN M; KUNG CHARLES; SKOUMBOURDIS AMANDA P; VEITH HENRIKE; SOUTHALL NOEL; WALSH MARTIN J; BRIMACOMBE KYLE R; LEISTER WILLIAM; LUNT SOPHIA Y; JOHNSON ZACHARY R; YEN KATHARINE E; KUNII KAIKO; DAVIDSON SHAWN M; CHRISTOFK HEATHER R; AUSTIN CHRISTOPHER P; INGLESE JAMES; HARRIS MARIAN H; ASARA JOHN M; STEPHANOPOULOS GREGORY; SALITURO FRANCESCO G; JIN SHENGFANG; DANG LENNY; AULD DOUGLAS S; PARK HEEWON; CANTLEY LEWIS C; THOMAS CRAIG J; HEIDEN MATTHEW G VANDER,期刊:NATURE CHEMICAL BIOLOGY, 页码:839-847 , 文章类型: Article,,卷期:2012年8-10]
- Cancer cells engage in a metabolic program to enhance biosynthesis and support cell proliferation. The regulatory properties of pyruvate kinase M2 (PKM2) influence altered glucose metabolism in cancer. The interaction of...
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