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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共13条记录   pVHL and PTEN tumour suppressor proteins cooperatively suppress kidney cyst formation [作者：Frew, IJ; Thoma, CR; Georgiev, S; Minola, A; Hitz, M; Montani, M; Moch, H; Krek, W,期刊：EMBO journal, 页码：1747-1757 , 文章类型： Article，,卷期：2008年27-12] In patients with von Hippel-Lindau (VHL) disease, renal cysts and clear cell renal cell carcinoma (ccRCC) arise from renal tubular epithelial cells containing biallelic inactivation of the VHL tumour suppressor gene. How... Structure of Escherichia coli tyrosine kinase Etk reveals a novel activation mechanism [作者：Lee, DC; Zheng, JM; She, YM; Jia, ZC,期刊：EMBO journal, 页码：1758-1766 , 文章类型： Article，,卷期：2008年27-12] While protein tyrosine (Tyr) kinases (PTKs) have been extensively characterized in eukaryotes, far less is known about their emerging counterparts in prokaryotes. The inner-membrane Wzc/Etk protein belongs to the bacteri... Structural model of the circadian clock KaiB-KaiC complex and mechanism for modulation of KaiC phosphorylation [作者：Pattanayek, R; Williams, DR; Pattanayek, S; Mori, T; Johnson, CH; Stewart, PL; Egli, M,期刊：EMBO journal, 页码：1767-1778 , 文章类型： Article，,卷期：2008年27-12] The circadian clock of the cyanobacterium Synechococcus elongatus can be reconstituted in vitro by the KaiA, KaiB and KaiC proteins in the presence of ATP. The principal clock component, KaiC, undergoes regular cycles be... The Moraxella adhesin UspA1 binds to its human CEACAM1 receptor by a deformable trimeric coiled-coil [作者：Conners, R; Hill, DJ; Borodina, E; Agnew, C; Daniell, SJ; Burton, NM; Sessions, RB; Clarke, AR; Catto, LE; Lammie, D; Wess, T; Brady, RL; Virji, M,期刊：EMBO journal, 页码：1779-1789 , 文章类型： Article，,卷期：2008年27-12] Moraxella catarrhalis is a ubiquitous human-specific bacterium commonly associated with upper and lower respiratory tract infections, including otitis media, sinusitis and chronic obstructive pulmonary disease. The bacte... beta-catenin asymmetry is regulated by PLA(1) and retrograde traffic in C-elegans stem cell divisions [作者：Kanamori, T; Inoue, T; Sakamoto, T; Gengyo-Ando, K; Tsujimoto, M; Mitani, S; Sawa, H; Aoki, J; Arai, H,期刊：EMBO journal, 页码：1647-1657 , 文章类型： Article，,卷期：2008年27-12] Asymmetric division is an important property of stem cells. In Caenorhabditis elegans, the Wnt/beta-catenin asymmetry pathway determines the polarity of most asymmetric divisions. The Wnt signalling components such as be... VE-statin/egfl7 regulates vascular elastogenesis by interacting with lysyl oxidases [作者：Lelievre, E; Hinek, A; Lupu, F; Buquet, C; Soncin, F; Mattot, V,期刊：EMBO journal, 页码：1658-1670 , 文章类型： Article，,卷期：2008年27-12] We previously characterized VE-statin/egfl7, a protein that is exclusively secreted by endothelial cells and modulates smooth muscle cell migration. Here, we show that VE-statin/ egfl7 is the first known natural negative... Activated macrophages promote Wnt signalling through tumour necrosis factor-alpha in gastric tumour cells [作者：Oguma, K; Oshima, H; Aoki, M; Uchio, R; Naka, K; Nakamura, S; Hirao, A; Saya, H; Taketo, MM; Oshima, M,期刊：EMBO journal, 页码：1671-1681 , 文章类型： Article，,卷期：2008年27-12] The activation of Wnt/beta-catenin signalling has an important function in gastrointestinal tumorigenesis. It has been suggested that the promotion of Wnt/beta-catenin activity beyond the threshold is important for carci... Altered subcellular distribution of MSK1 induced by glucocorticoids contributes to NF-kappa B inhibition [作者：Beck, IM; Vanden Berghe, W; Vermeulen, L; Bougarne, N; Cruyssen, BV; Haegeman, G; De Bosscher, K,期刊：EMBO journal, 页码：1682-1693 , 文章类型： Article，,卷期：2008年27-12] Glucocorticoids are widely used anti-inflammatory and immunomodulatory agents, of which the action mechanism is mainly based on interference of hormone-activated glucocorticoid receptor (GR) with the activity of transcri... Alu element-mediated gene silencing [作者：Chen, LL; DeCerbo, JN; Carmichael, GG,期刊：EMBO journal, 页码：1694-1705 , 文章类型： Article，,卷期：2008年27-12] The Alu elements are conserved similar to 300-nucleotide-long repeat sequences that belong to the SINE family of retrotransposons found abundantly in primate genomes. Pairs of inverted Alu repeats in RNA can form duplex ... Complementary roles of initiation factor 1 and ribosome recycling factor in 70S ribosome splitting [作者：Pavlov, MY; Antoun, A; Lovmar, M; Ehrenberg, M,期刊：EMBO journal, 页码：1706-1717 , 文章类型： Article，,卷期：2008年27-12] We demonstrate that ribosomes containing a messenger RNA (mRNA) with a strong Shine-Dalgarno sequence are rapidly split into subunits by initiation factors 1 (IF1) and 3 (IF3), but slowly split by ribosome recycling fact... Coupling of DNA unwinding to nucleotide hydrolysis in a ring-shaped helicase [作者：Donmez, I; Patel, SS,期刊：EMBO journal, 页码：1718-1726 , 文章类型： Article，,卷期：2008年27-12] The ring-shaped T7 helicase uses the energy of dTTP hydrolysis to perform the mechanical work of translocation and base pair (bp) separation. We have shown that the unwinding rate of T7 helicase decreases with increasing... Branch migration enzyme as a Brownian ratchet [作者：Rasnik, I; Jeong, YJ; McKinney, SA; Rajagopal, V; Patel, SS; Ha, T,期刊：EMBO journal, 页码：1727-1735 , 文章类型： Article，,卷期：2008年27-12] In recent years, it has been shown that helicases are able to perform functions beyond their traditional role in unwinding of double-stranded nucleic acids; yet the mechanistic aspects of these different activities are n... The iron-sulphur protein Ind1 is required for effective complex I assembly [作者：Bych, K; Kerscher, S; Netz, DJA; Pierik, AJ; Zwicker, K; Huynen, MA; Lill, R; Brandt, U; Balk, J,期刊：EMBO journal, 页码：1736-1746 , 文章类型： Article，,卷期：2008年27-12] NADH: ubiquinone oxidoreductase (complex I) of the mitochondrial inner membrane is a multi-subunit protein complex containing eight iron-sulphur (Fe-S) clusters. Little is known about the assembly of complex I and its Fe...