- LIS1 and NDEL1 coordinate the plus-end-directed transport of cytoplasmic dynein
[作者：Yamada, M; Toba, S; Yoshida, Y; Haratani, K; Mori, D; Yano, Y; Mimori-Kiyosue, Y; Nakamura, T; Itoh, K; Fushiki, S; Setou, M; Wynshaw-Boris, A; Torisawa, T; Toyoshima, YY; Hirotsune, S,期刊：EMBO journal, 页码：2471-2483 , 文章类型： Article，,卷期：2008年27-19]
- LIS1 was first identified as a gene mutated in human classical lissencephaly sequence. LIS1 is required for dynein activity, but the underlying mechanism is poorly understood. Here, we demonstrate that LIS1 suppresses th...
- Regulatory interactions between IRG resistance GTPases in the cellular response to Toxoplasma gondii
[作者：Hunn, JP; Koenen-Waisman, S; Papic, N; Schroeder, N; Pawlowski, N; Lange, R; Kaiser, F; Zerrahn, J; Martens, S; Howard, JC,期刊：EMBO journal, 页码：2495-2509 , 文章类型： Article，,卷期：2008年27-19]
- Members of the immunity-related GTPase (IRG) family are interferon-inducible resistance factors against a broad spectrum of intracellular pathogens including Toxoplasma gondii. The molecular mechanisms governing the func...
- CENP-V is required for centromere organization, chromosome alignment and cytokinesis
[作者：Tadeu, AMB; Ribeiro, S; Johnston, J; Goldberg, I; Gerloff, D; Earnshaw, WC,期刊：EMBO journal, 页码：2510-2522 , 文章类型： Article，,卷期：2008年27-19]
- The mechanism of mitotic chromosome condensation is poorly understood, but even less is known about the mechanism of formation of the primary constriction, or centromere. A proteomic analysis of mitotic chromosome scaffo...
- A mono-allelic bivalent chromatin domain controls tissue-specific imprinting at Grb10
[作者：Sanz, LA; Chamberlain, S; Sabourin, JC; Henckel, A; Magnuson, T; Hugnot, JP; Feil, R; Arnaud, P,期刊：EMBO journal, 页码：2523-2532 , 文章类型： Article，,卷期：2008年27-19]
- Genomic imprinting is a developmental mechanism that mediates parent-of-origin-specific expression in a subset of genes. How the tissue specificity of imprinted gene expression is controlled remains poorly understood. As...
- Translational bypassing without peptidyl-tRNA anticodon scanning of coding gap mRNA
[作者：Wills, NM; O'Connor, M; Nelson, CC; Rettberg, CC; Huang, WM; Gesteland, RF; Atkins, JF,期刊：EMBO journal, 页码：2533-2544 , 文章类型： Article，,卷期：2008年27-19]
- Half the ribosomes translating the mRNA for phage T4 gene 60 topoisomerase subunit bypass a 50 nucleotide coding gap between codons 46 and 47. The pairing of codon 46 with its cognate peptidyl-tRNA anticodon dissociates,...
- CSB protein is (a direct target of HIF-1 and) a critical mediator of the hypoxic response
[作者：Filippi, S; Latini, P; Frontini, M; Palitti, F; Egly, JM; Proietti-De-Santis, L,期刊：EMBO journal, 页码：2545-2556 , 文章类型： Article，,卷期：2008年27-19]
- Cockayne syndrome (CS) is a rare genetic disease characterized by neurological problems, growth failure and premature ageing. Many of these features cannot simply be ascribed to the defect that CS cells display during tr...
- Cell-free propagation of prion strains
[作者：Castilla, J; Morales, R; Saa, P; Barria, M; Gambetti, P; Soto, C,期刊：EMBO journal, 页码：2557-2566 , 文章类型： Article，,卷期：2008年27-19]
- Prions are the infectious agents responsible for prion diseases, which appear to be composed exclusively by the misfolded prion protein (PrPSc). Disease is transmitted by the autocatalytic propagation of PrPSc misfolding...
- Dissecting the role of Aurora A during spindle assembly
[作者：Sardon, T; Peset, I; Petrova, B; Vernos, I,期刊：EMBO journal, 页码：2567-2579 , 文章类型： Article，,卷期：2008年27-19]
- The centrosomal kinase Aurora A (AurA) is required for cell cycle progression, centrosome maturation and spindle assembly. However, the way it participates in spindle assembly is still quite unclear. Using the Xenopus eg...
- Cripto recruits Furin and PACE4 and controls Nodal trafficking during proteolytic maturation
[作者：Blanchet, MH; Le Good, JA; Mesnard, D; Oorschot, V; Baflast, S; Minchiotti, G; Klumperman, J; Constam, DB,期刊：EMBO journal, 页码：2580-2591 , 文章类型： Article，,卷期：2008年27-19]
- The glycosylphosphatidylinositol (GPI)-anchored proteoglycan Cripto binds Nodal and its type I receptor Alk4 to activate Smad2,3 transcription factors, but a role during Nodal precursor processing has not been described....
- Germline V-genes sculpt the binding site of a family of antibodies neutralizing human cytomegalovirus
[作者：Thomson, CA; Bryson, S; McLean, GR; Creagh, AL; Pai, EF; Schrader, JW,期刊：EMBO journal, 页码：2592-2602 , 文章类型： Article，,卷期：2008年27-19]
- Immunoglobulin genes are generated somatically through specialized mechanisms resulting in a vast repertoire of antigen-binding sites. Despite the stochastic nature of these processes, the V-genes that encode most of the...
- NCAM-induced focal adhesion assembly: a functional switch upon loss of E-cadherin
[作者：Lehembre, F; Yilmaz, M; Wicki, A; Schomber, T; Strittmatter, K; Ziegler, D; Kren, A; Went, P; Derksen, PWB; Berns, A; Jonkers, J; Christofori, G,期刊：EMBO journal, 页码：2603-2615 , 文章类型： Article，,卷期：2008年27-19]
- Loss of expression of the cell-cell adhesion molecule E-cadherin is a hallmark of epithelial-mesenchymal transition (EMT) in development and in the progression from epithelial tumours to invasive and metastatic cancers. ...
- Concerted microRNA control of Hedgehog signalling in cerebellar neuronal progenitor and tumour cells
[作者：Ferretti, E; De Smaele, E; Miele, E; Laneve, P; Po, A; Pelloni, M; Paganelli, A; Di Marcotullio, L; Caffarelli, E; Screpanti, I; Bozzoni, I; Gulino, A,期刊：EMBO journal, 页码：2616-2627 , 文章类型： Article，,卷期：2008年27-19]
- MicroRNAs (miRNA) are crucial post-transcriptional regulators of gene expression and control cell differentiation and proliferation. However, little is known about their targeting of specific developmental pathways. Hedg...
- Structural basis for LEAFY floral switch function and similarity with helix-turn-helix proteins
[作者：Hames, C; Ptchelkine, D; Grimm, C; Thevenon, E; Moyroud, E; Gerard, F; Martiel, JL; Benlloch, R; Parcy, F; Muller, CW,期刊：EMBO journal, 页码：2628-2637 , 文章类型： Article，,卷期：2008年27-19]
- The LEAFY (LFY) protein is a key regulator of flower development in angiosperms. Its gradually increased expression governs the sharp floral transition, and LFY subsequently controls the patterning of flower meristems by...
- A glial DEG/ENaC channel functions with neuronal channel DEG-1 to mediate specific sensory functions in C. elegans (vol 27, pg 2388, 2008)
[作者：Wang, Y; Apicella, A; Lee, SK; Ezcurra, M; Slone, RD; Goldmit, M; Schafer, WR; Shaham, S; Driscoll, M; Bianchi, L,期刊：EMBO journal, 页码：2638-2638 , 文章类型： Correction，,卷期：2008年27-19]
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