- Dysfunction of Extrasynaptic GABAergic Transmission in Phospholipase C-Related, but Catalytically Inactive Protein 1 Knockout Mice Is Associated with an Epilepsy Phenotype
[作者:Zhu, G; Yoshida, S; Migita, K; Yamada, J; Mori, F; Tomiyama, M; Wakabayashi, K; Kanematsu, T; Hirata, M; Kaneko, S; Ueno, S; Okada, M,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:520-528 , 文章类型: Article,,卷期:2012年340-3]
- Phospholipase C-related, but catalytically inactive protein (PRIP) was first identified as a novel inositol 1,4,5-triphosphate binding protein. The PRIP-1 subtype is expressed predominantly in the central nervous system ...
- Characterization of COR627 and COR628, Two Novel Positive Allosteric Modulators of the GABA(B) Receptor
[作者:Castelli, MP; Casu, A; Casti, P; Lobina, C; Carai, MAM; Colombo, G; Solinas, M; Giunta, D; Mugnaini, C; Pasquini, S; Tafi, A; Brogi, S; Gessa, GL; Corelli, F,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:529-538 , 文章类型: Article,,卷期:2012年340-3]
- The potential efficacy of GABA(B) receptor agonists in the treatment of pain, drug addiction, epilepsy, cognitive dysfunctions, and anxiety disorders is supported by extensive preclinical and clinical evidence. However, ...
- 2,2,2-Tribromoethanol Phase-Shifts the Circadian Rhythm of the Liver Clock in Per2::Luciferase Knockin Mice: Lack of Dependence on Anesthetic Activity
[作者:Kubo, Y; Tahara, Y; Hirao, A; Shibata, S,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:698-705 , 文章类型: Article,,卷期:2012年340-3]
- Comprehensive gene expression profiling in mice in response to the inhalation of sevoflurane has revealed that circadian clock gene expression is affected strongly in the liver, heart, lung, and kidney, in this order, bu...
- The Antipsychotic Drug Loxapine Is an Opener of the Sodium-Activated Potassium Channel Slack (Slo2.2)
[作者:Biton, B; Sethuramanujam, S; Picchione, KE; Bhattacharjee, A; Khessibi, N; Chesney, F; Lanneau, C; Curet, O; Avenet, P,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:706-715 , 文章类型: Article,,卷期:2012年340-3]
- Sodium-activated potassium (K(Na)) channels have been suggested to set the resting potential, to modulate slow after-hyperpolarizations, and to control bursting behavior or spike frequency adaptation (Trends Neurosci 28:...
- Pharmacokinetic/Pharmacodynamic Modeling of Crizotinib for Anaplastic Lymphoma Kinase Inhibition and Antitumor Efficacy in Human Tumor Xenograft Mouse Models
[作者:Yamazaki, S; Vicini, P; Shen, ZZ; Zou, HY; Lee, J; Li, QH; Christensen, JG; Smith, BJ; Shetty, B,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:549-557 , 文章类型: Article,,卷期:2012年340-3]
- Crizotinib [Xalkori; PF02341066; (R)-3-[1-(2,6-dichloro-3-fluorophenyl)-ethoxy]-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)-pyridin-2-ylamine] is an orally available dual inhibitor of anaplastic lymphoma kinase (ALK) and hepato...
- Effects of Neonatal Antiepileptic Drug Exposure on Cognitive, Emotional, and Motor Function in Adult Rats
[作者:Forcelli, PA; Kozlowski, R; Snyder, C; Kondratyev, A; Gale, K,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:558-566 , 文章类型: Article,,卷期:2012年340-3]
- Despite the potent proapoptotic effect of several antiepileptic drugs (AEDs) in developmental rodent models, little is known about the long-term impact of exposure during brain development. Clinically, this is of growing...
- The Role of beta-Arrestin2 in the Mechanism of Morphine Tolerance in the Mouse and Guinea Pig Gastrointestinal Tract
[作者:Kang, MH; Maguma, HT; Smith, TH; Ross, GR; Dewey, WL; Akbarali, HI,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:567-576 , 文章类型: Article,,卷期:2012年340-3]
- beta-Arrestin2 has been reported to play an essential role in analgesic tolerance. Analgesic tolerance without concomitant tolerance to constipation is a limiting side effect of chronic morphine treatment. Because tolera...
- Apolipoprotein A-I (ApoA-I) Mimetic Peptide P2a by Restoring Cholesterol Esterification Unmasks ApoA-I Anti-Inflammatory Endogenous Activity In Vivo
[作者:Bucci, M; Cigliano, L; Vellecco, V; D'Andrea, LD; Ziaco, B; Rossi, A; Sautebin, L; Carlucci, A; Abrescia, P; Pedone, C; Ianaro, A; Cirino, G,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:716-722 , 文章类型: Article,,卷期:2012年340-3]
- The acute-phase protein haptoglobin (Hpt) binds apolipoprotein A-I (ApoA-I) and impairs its action on lecithin-cholesterol acyltransferase, an enzyme that plays a key role in reverse cholesterol transport. We have previo...
- Cobinamides Are Novel Coactivators of Nitric Oxide Receptor That Target Soluble Guanylyl Cyclase Catalytic Domain
[作者:Sharina, I; Sobolevsky, M; Doursout, MF; Gryko, D; Martin, E,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:723-732 , 文章类型: Article,,卷期:2012年340-3]
- Soluble guanylyl cyclase (sGC), a ubiquitously expressed heme-containing receptor for nitric oxide (NO), is a key mediator of NO-dependent processes. In addition to NO, a number of synthetic compounds that target the hem...
- Epigenetic Augmentation of the Macrophage Inflammatory Protein 2/C-X-C Chemokine Receptor Type 2 Axis through Histone H3 Acetylation in Injured Peripheral Nerves Elicits Neuropathic Pain
[作者:Kiguchi, N; Kobayashi, Y; Maeda, T; Fukazawa, Y; Tohya, K; Kimura, M; Kishioka, S,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:577-587 , 文章类型: Article,,卷期:2012年340-3]
- Although there is growing evidence showing that the involvement of chemokines in the pathogenesis of neuropathic pain is associated with neuroinflammation, the details are unclear. We investigated the C-X-C chemokine lig...
- The Selective M(1) Muscarinic Cholinergic Agonist CDD-0102A Enhances Working Memory and Cognitive Flexibility
[作者:Ragozzino, ME; Artis, S; Singh, A; Twose, TM; Beck, JE; Messer, WS,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:588-594 , 文章类型: Article,,卷期:2012年340-3]
- Various neurodegenerative diseases and psychiatric disorders are marked by alterations in brain cholinergic function and cognitive deficits. Efforts to alleviate such deficits have been limited by a lack of selective M(1...
- Roles of the M1 Muscarinic Acetylcholine Receptor Subtype in the Regulation of Basal Ganglia Function and Implications for the Treatment of Parkinson's Disease
[作者:Xiang, ZX; Thompson, AD; Jones, CK; Lindsley, CW; Conn, PJ,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:595-603 , 文章类型: Article,,卷期:2012年340-3]
- Antagonists of the muscarinic acetylcholine receptors (mAChRs) were among the first treatments for Parkinson's disease. However, the clinical utility of mAChR antagonists is limited by adverse effects associated with the...
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