The pH-sensitive drug delivery systems could be triggered by a mild acidic environment, such as that occurring in solid tumors, inflammatory tissues and intracellular endosomal compartments. Moreover, the cytoplasmic ...

Background: Transdifferentiation of exocrine pancreatic cells into insulin-secreting cells may be an alternative or a support to islet transplantation-based therapy of Type 1 diabetes. The application relates to a met...

Background: A growing number of patent applications on dopamine (DA) D-3 receptors have been filed over the last 10 years. The increased interest in this target correlates with evidence that implicates the DA D-3 rece...

Background: Most invasive and/or metastasizing cancers are resistant to apoptosis and, thus, to pro-apoptotic drugs, although certain drugs may display a level of sensitivity to pro-autophagic drugs. Autophagy dysfunc...

Background: The superfamily of nuclear receptors (NRs) comprises ligand-gated and ligand-independent transcription factors, modulating genetic programs mostly by binding to specific DNA elements. NRs not only control ...

Background: Together with 2 integrins and selectins, alpha 4 integrins mediate lymphocyte arrest, extravasation and migration to sites of inflammation. They have been validated as therapeutic targets for inflammatory ...

Background: Coronary and peripheral artery diseases are highly prevalent diseases, which are characterised by an unmet medical need in the more advanced stages of disease. These comprise the need for vessel regenerati...

Background: The 'targeted therapy' has been defined as an innovative therapy designed to interfere with molecular targets playing a critical role in tumour growth or progression. The epidermal growth factor receptor (...

Background: Although cystic fibrosis (CF) seems a good candidate for gene therapy (GT), 15 years of intense investigations and a number of clinical trials have not yet produced a viable clinical GT strategy. Objective...