- A Competitive Inhibitor Traps LeuT in an Open-to-Out Conformation
[作者：Singh, SK; Piscitelli, CL; Yamashita, A; Gouaux, E,期刊：Science, 页码：1655-1661 , 文章类型： Article，,卷期：2008年322-5908]
- Secondary transporters are workhorses of cellular membranes, catalyzing the movement of small molecules and ions across the bilayer and coupling substrate passage to ion gradients. However, the conformational changes tha...
- Developmental Patterning by Mechanical Signals in Arabidopsis
[作者：Hamant, O; Heisler, MG; Jonsson, H; Krupinski, P; Uyttewaal, M; Bokov, P; Corson, F; Sahlin, P; Boudaoud, A; Meyerowitz, EM; Couder, Y; Traas, J,期刊：Science, 页码：1650-1655 , 文章类型： Article，,卷期：2008年322-5908]
- A central question in developmental biology is whether and how mechanical forces serve as cues for cellular behavior and thereby regulate morphogenesis. We found that morphogenesis at the Arabidopsis shoot apex depends o...
- Mechanism of Threading a Polymer Through a Macrocyclic Ring
[作者：Deutman, ABC; Monnereau, C; Elemans, JAAW; Ercolani, G; Nolte, RJM; Rowan, AE,期刊：Science, 页码：1668-1671 , 文章类型： Article，,卷期：2008年322-5908]
- The translocation of biopolymers through pores and channels plays a fundamental role in numerous biological processes. We describe here the mechanism of the threading of a series of polymer chains through a synthetic mac...
- A Dynamic Marine Calcium Cycle During the Past 28 Million Years
[作者：Griffith, EM; Paytan, A; Caldeira, K; Bullen, TD; Thomas, E,期刊：Science, 页码：1671-1674 , 文章类型： Article，,卷期：2008年322-5908]
- Multiple lines of evidence have shown that the isotopic composition and concentration of calcium in seawater have changed over the past 28 million years. A high- resolution, continuous seawater calcium isotope ratio curv...
- Earthquake Supercycles Inferred from Sea-Level Changes Recorded in the Corals of West Sumatra
[作者：Sieh, K; Natawidjaja, DH; Meltzner, AJ; Shen, CC; Cheng, H; Li, KS; Suwargadi, BW; Galetzka, J; Philibosian, B; Edwards, RL,期刊：Science, 页码：1674-1678 , 文章类型： Article，,卷期：2008年322-5908]
- Records of relative sea- level change extracted from corals of the Mentawai islands, Sumatra, imply that this 700- kilometer- long section of the Sunda megathrust has generated broadly similar sequences of great earthqua...
- Shock Metamorphism of Bosumtwi Impact Crater Rocks, Shock Attenuation, and Uplift Formation
[作者：Ferriere, L; Koeberl, C; Ivanov, BA; Reimold, WU,期刊：Science, 页码：1678-1681 , 文章类型： Article，,卷期：2008年322-5908]
- Shock wave attenuation rate and formation of central uplifts are not precisely constrained for moderately sized complex impact structures. The distribution of shock metamorphism in drilled basement rocks from the 10.5- k...
- The Spreading of Disorder
[作者：Keizer, K; Lindenberg, S; Steg, L,期刊：Science, 页码：1681-1685 , 文章类型： Article，,卷期：2008年322-5908]
- Imagine that the neighborhood you are living in is covered with graffiti, litter, and unreturned shopping carts. Would this reality cause you to litter more, trespass, or even steal? A thesis known as the broken windows ...
- Germ Cell-Intrinsic and -Extrinsic Factors Govern Meiotic Initiation in Mouse Embryos
[作者：Lin, YF; Gill, ME; Koubova, J; Page, DC,期刊：Science, 页码：1685-1687 , 文章类型： Article，,卷期：2008年322-5908]
- Retinoic acid ( RA) is an essential extrinsic inducer of meiotic initiation in mammalian germ cells. However, RA acts too widely in mammalian development to account, by itself, for the cell- type and temporal specificity...
- Structure and Functional Role of Dynein's Microtubule-Binding Domain
[作者：Carter, AP; Garbarino, JE; Wilson-Kubalek, EM; Shipley, WE; Cho, C; Milligan, RA; Vale, RD; Gibbons, IR,期刊：Science, 页码：1691-1695 , 文章类型： Article，,卷期：2008年322-5908]
- Dynein motors move various cargos along microtubules within the cytoplasm and power the beating of cilia and flagella. An unusual feature of dynein is that its microtubule- binding domain ( MTBD) is separated from its ri...
- Genomic Loss of microRNA-101 Leads to Overexpression of Histone Methyltransferase EZH2 in Cancer
[作者：Varambally, S; Cao, Q; Mani, RS; Shankar, S; Wang, XS; Ateeq, B; Laxman, B; Cao, XH; Jing, XJ; Ramnarayanan, K; Brenner, JC; Yu, JD; Kim, JH; Han, B; Tan, P; Kumar-Sinha, C; Lonigro, RJ; Palanisamy, N; Maher, CA; Chinnaiyan, AM,期刊：Science, 页码：1695-1699 , 文章类型： Article，,卷期：2008年322-5908]
- Enhancer of zeste homolog 2 ( EZH2) is a mammalian histone methyltransferase that contributes to the epigenetic silencing of target genes and regulates the survival and metastasis of cancer cells. EZH2 is overexpressed i...
- Modanfinil Shifts Human Locus Coeruleus to Low-Tonic, High-Phasic Activity During Functional MRI
[作者：Minzenberg, MJ; Watrous, AJ; Yoon, JH; Ursu, S; Carter, CS,期刊：Science, 页码：1700-1702 , 文章类型： Article，,卷期：2008年322-5908]
- Models of cognitive control posit a key modulatory role for the pontine locus coeruleus- norepinephrine (LC-NE) system. In nonhuman primates, phasic LC- NE activity confers adaptive adjustments in cortical gain in task- ...
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