- In vitro multimerization and membrane insertion of bacterial outer membrane secretin PulD
[作者:Guilvout, I; Chami, M; Berrier, C; Ghazi, A; Engel, A; Pugsley, AP; Bayan, N,期刊:Journal of Molecular Biology, 页码:13-23 , 文章类型: Article,,卷期:2008年382-1]
- Synthesis of the Klebsiella oxytoca outer membrane secretin PulD, or its membrane-associated core domain, in a liposome-supplemented Escherichia coli in vitro transcription-translation system resulted in the formation of...
- The exon-3-encoded domain of IL-15R alpha contributes to IL-15 high-affinity binding and is crucial for the IL-15 antagonistic effect of soluble IL-15R alpha
[作者:Bouchaud, G; Garrigue-Antar, L; Sole, V; Quemener, A; Boublik, Y; Mortier, E; Perdreau, H; Jacques, Y; Plet, A,期刊:Journal of Molecular Biology, 页码:1-12 , 文章类型: Article,,卷期:2008年382-1]
- We previously showed that a natural soluble form of interleukin-15 (IL-15) R alpha corresponding to the full-length ectodomain of IL-15R alpha behaved as a potent antagonist of IL-15 action through whereas a recombinant ...
- Id-1 induces proteasome-dependent degradation of the HBX protein
[作者:Ling, MT; Chiu, YT; Lee, TKW; Leung, SCL; Fung, MKL; Wang, XH; Wong, KF; Wong, YC,期刊:Journal of Molecular Biology, 页码:34-43 , 文章类型: Article,,卷期:2008年382-1]
- Id-1 is a member of the HLH protein family that regulates a wide range of cellular processes such as cell proliferation, apoptosis, senescence and overexpression of Id-1 was recently suggested to play roles in the develo...
- Structure of lumazine protein, an optical transponder of luminescent bacteria
[作者:Chatwell, L; Illarionova, V; Illarionov, B; Eisenreich, W; Huber, R; Skerra, A; Bacher, A; Fischer, M,期刊:Journal of Molecular Biology, 页码:44-55 , 文章类型: Article,,卷期:2008年382-1]
- The intensely fluorescent lumazine protein is believed to be involved in the bioluminescence of certain marine bacteria. The sequence of the catalytically inactive protein resembles that of the enzyme riboflavin synthase...
- Divalent metal ion complexes of S100B in the absence and presence of pentamidine
[作者:Charpentier, TH; Wilder, PT; Liriano, MA; Varney, KM; Pozharski, E; MacKerell, AD; Coop, A; Toth, EA; Weber, DJ,期刊:Journal of Molecular Biology, 页码:56-73 , 文章类型: Article,,卷期:2008年382-1]
- As part of an effort to inhibit S100B, structures of pentamidine (Pnt) bound to Ca2+-loaded and Zn2+, Ca2+-loaded S100B were determined by X-ray crystallography at 2.15 angstrom (R-free = 0.266) and 1.85 angstrom (R-free...
- SecA, the motor of the secretion machine, binds diverse partners on one interactive surface
[作者:Cooper, DB; Smith, VF; Crane, JM; Roth, HC; Lilly, AA; Randall, LL,期刊:Journal of Molecular Biology, 页码:74-87 , 文章类型: Article,,卷期:2008年382-1]
- In all living cells, regulated passage across membranes of specific proteins occurs through a universally conserved secretory channel. In bacteria and chloroplasts, the energy for the mechanical work of moving polypeptid...
- Scrapie prion protein structural constraints obtained by limited proteolysis and mass spectrometry
[作者:Sajnani, G; Pastrana, MA; Dynin, I; Onisko, B; Requena, JR,期刊:Journal of Molecular Biology, 页码:88-98 , 文章类型: Article,,卷期:2008年382-1]
- Elucidation of the structure of scrapie prion protein (PrPSc), essential to understand the molecular mechanism of prion transmission, continues to be one of the major challenges in prion research and is hampered by the i...
- Crystal structure of a glutamate/aspartate binding protein complexed with a glutamate molecule: Structural basis of ligand specificity at atomic resolution
[作者:Hu, YL; Fan, CP; Fu, GS; Zhu, DY; Jin, Q; Wang, DC,期刊:Journal of Molecular Biology, 页码:99-111 , 文章类型: Article,,卷期:2008年382-1]
- The crystal structure of a periplasmic L-aspartate/L-glutamate binding protein (DEBP) from Shigella flexneri complexed with all L-glutamate molecule has been determined and refined to an atomic resolution of 1.0 angstrom...
- Structural basis for the interaction between the cytoplasmic domain of the hyaluronate receptor layilin and the talin F3 subdomain
[作者:Wegener, KL; Basran, J; Bagshaw, CR; Campbell, ID; Roberts, GCK; Critchley, DR; Barsukov, IL,期刊:Journal of Molecular Biology, 页码:112-126 , 文章类型: Article,,卷期:2008年382-1]
- Talin is a large cytoskeletal protein that is involved in coupling the integrin family of cell adhesion molecules to the actin cytoskeleton, colocalising with the integrins in focal adhesions (FAs). However, at the leadi...
- The role of aromatic phenylalanine residues in binding carotenoid to light-harvesting model and wild-type complexes
[作者:Garcia-Martin, A; Pazur, A; Wilhelm, B; Silber, M; Robert, B; Braun, P,期刊:Journal of Molecular Biology, 页码:154-166 , 文章类型: Article,,卷期:2008年382-1]
- The mode of carotenoid (Crt) binding to polypeptide and specifying its function is as yet largely unknown. Statistical analysis of major photosystems I and II suggests that aromatic residues make up a significant part of...
- Structural basis of PxxDY motif recognition in SH3 binding
[作者:Aitio, O; Hellman, M; Kesti, T; Klein, I; Samuilova, O; Paakkonen, K; Tossavainen, H; Saksela, K; Permi, P,期刊:Journal of Molecular Biology, 页码:167-178 , 文章类型: Article,,卷期:2008年382-1]
- We have determined the solution structure of epidermal growth factor receptor pathway substrate 8 (Eps8) L1 Src homology 3 (SH3) domain in complex with the PPVPNPDYEPIR peptide from the CDR cytoplasmic tail. Our structur...
- Visualization of the eEF2-80S ribosome transition-state complex by cryo-electron microscopy
[作者:Sengupta, J; Nilsson, J; Gursky, R; Kieldgaard, M; Nissen, P; Frank, J,期刊:Journal of Molecular Biology, 页码:179-187 , 文章类型: Article,,卷期:2008年382-1]
- In an attempt to understand ribosome-induced GTP hydrolysis on eEF2, we determined a 12.6-angstrom cryo-electron microscopy reconstruction of the eEF2-bound 80S ribosome in the presence of aluminum tetrafluoride and GDP,...
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