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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共16条记录   Evidence against Involvement of Aquaporin-4 in Cell-Cell Adhesion [作者：Zhang, H; Verkman, AS,期刊：Journal of Molecular Biology, 页码：1136-1143 , 文章类型： Article，,卷期：2008年382-5] Aquaporin-4 (AQP4) water channels are expressed strongly in glial cells, where they play a role in brain water balance, neuroexcitation, and glial cell migration. Here, we investigated a proposed new role of AQP4 in faci... The Tim8-Tim13 Complex Has Multiple Substrate Binding Sites and Binds Cooperatively to Tim23 [作者：Beverly, KN; Sawaya, MR; Schmid, E; Koehler, CM,期刊：Journal of Molecular Biology, 页码：1144-1156 , 文章类型： Article，,卷期：2008年382-5] The Tim8-Tim13 complex, located in the mitochondrial intermembrane space, functions in the TIM22 import pathway that mediates the import of the mitochondrial carriers Tim23, Tim22, and Tim17 into the mitochondrial inner ... Kinetic Coupling of Folding and Prolyl Isomerization of beta(2)-Microglobulin Studied by Mutational Analysis [作者：Sakata, M; Chatani, E; Kameda, A; Sakurai, K; Naiki, H; Goto, Y,期刊：Journal of Molecular Biology, 页码：1242-1255 , 文章类型： Article，,卷期：2008年382-5] beta(2)-Microglobulin (beta 2-m), a protein responsible for dialysis-related amyloidosis, adopts a typical immunoglobulin domain fold with the N-terminal peptide bond of Pro32 in a cis isomer. The refolding of beta 2-m i... Cryo-EM Structure of the Yeast ATP Synthase [作者：Lau, WCY; Baker, LA; Rubinstein, JL,期刊：Journal of Molecular Biology, 页码：1256-1264 , 文章类型： Article，,卷期：2008年382-5] We have used electron cryomicroscopy of single particles to determine the structure of the ATP synthase from Saccharomyces cerevisiae. The resulting map at 24 angstrom resolution can accommodate atomic models of the F-1-... Computational Redesign of the SHV-1 beta-Lactamase/beta-Lactamase Inhibitor Protein Interface [作者：Reynolds, KA; Hanes, MS; Thomson, JM; Antczak, AJ; Berger, JM; Bonomo, RA; Kirsch, JF; Handel, TM,期刊：Journal of Molecular Biology, 页码：1265-1275 , 文章类型： Article，,卷期：2008年382-5] beta-lactamases are enzymes that catalyze the hydrolysis of beta-lactam antibiotics. beta-lactamase/beta-lactamase inhibitor protein (BLIP) complexes are emerging as a well characterized experimental model system for stu... The Malignant Brain Tumor Repeats of Human SCML2 Bind to Peptides Containing Monomethylated Lysine [作者：Santiveri, CM; Lechtenberg, BC; Allen, MD; Sathyamurthy, A; Jaulent, AM; Freund, SMV; Bycroft, M,期刊：Journal of Molecular Biology, 页码：1107-1112 , 文章类型： Article，,卷期：2008年382-5] SCML2 (sex comb on midleg-like 2) is a constituent of the Polycomb repressive complex 1, a large multiprotein assembly required for the repression of developmental control genes. It contains two MBT (malignant brain tumo... Structural Insight into pH-induced Conformational Changes within the Native Human Transthyretin Tetramer [作者：Palaninathan, SK; Mohamedmohaideen, NN; Snee, WC; Kelly, JW; Sacchettini, JC,期刊：Journal of Molecular Biology, 页码：1157-1167 , 文章类型： Article，,卷期：2008年382-5] Acidification of the transthyretin (TTR) tetramer facilitates dissociation and conformational changes in the protein, allowing alternatively folded monomers to self-assemble into insoluble amyloid fibers by a downhill po... IL-22R, IL-10R2, and IL-22BP Binding Sites Are Topologically Juxtaposed on Adjacent and Overlapping Surfaces of IL-22 [作者：Wu, PW; Li, J; Kodangattil, SR; Luxenberg, DP; Bennett, F; Martino, M; Collins, M; Dunussi-Joannopoulos, K; Gill, DS; Wolfman, NM; Fouser, LA,期刊：Journal of Molecular Biology, 页码：1168-1183 , 文章类型： Article，,卷期：2008年382-5] Interleukin (IL) 22 is a type II cytokine that is produced by immune cells and acts on nonimmune cells to regulate local tissue inflammation. As a product of the recently identified T helper 17 lineage of CD4(+) effector... Structural Basis of Poly(3-Hydroxybutyrate) Hydrolysis by PhaZ7 Depolymerase from Paucimonas lemoignei [作者：Papageorgiou, AC; Hermawan, S; Singh, CB; Jendrossek, D,期刊：Journal of Molecular Biology, 页码：1184-1194 , 文章类型： Article，,卷期：2008年382-5] The crystal structure of poly(3-hydroxybutyrate) (PHB) depolymerase PhaZ7 purified from Paucimonas lemoignei was determined at 1.90 angstrom resolution. The structure consists of a single domain with an alpha/beta hydrol... GAPDH Is Conformationally and Functionally Altered in Association with Oxidative Stress in Mouse Models of Amyotrophic Lateral Sclerosis [作者：Pierce, A; Mirzaei, H; Muller, F; De Waal, E; Taylor, AB; Leonard, S; Van Remmen, H; Regnier, F; Richardson, A; Chaudhuri, A,期刊：Journal of Molecular Biology, 页码：1195-1210 , 文章类型： Article，,卷期：2008年382-5] It is proposed that conformational changes induced in proteins by oxidation can lead to loss of activity or protein aggregation through exposure of hydrophobic residues and alteration in surface hydrophobicity. Because i... Identification of Protein Interaction Partners and Protein-Protein Interaction Sites [作者：Sacquin-Mora, S; Carbone, A; Lavery, R,期刊：Journal of Molecular Biology, 页码：1276-1289 , 文章类型： Article，,卷期：2008年382-5] Rigid-body docking has become quite successful in predicting the correct conformations of binary protein complexes, at least when the constituent proteins do not undergo large conformational changes upon binding. However... Signal Discrimination by Differential Regulation of Protein Stability in Quorum Sensing [作者：Smith, C; Song, H; You, LC,期刊：Journal of Molecular Biology, 页码：1290-1297 , 文章类型： Article，,卷期：2008年382-5] Quorum sensing (QS) is a communication mechanism exploited by a large variety of bacteria to coordinate gene expression at the population level. In Gram-negative bacteria, QS Occurs via synthesis and detection of small c... Crystal Structure of the Ig1 Domain of the Neural Cell Adhesion Molecule NCAM2 Displays Domain Swapping [作者：Rasmussen, KK; Kulahin, N; Kristensen, O; Poulsen, JCN; Sigurskjold, BW; Kastrup, JS; Berezin, V; Bock, E; Walmod, PS; Gajhede, M,期刊：Journal of Molecular Biology, 页码：1113-1120 , 文章类型： Article，,卷期：2008年382-5] The crystal structure of the first immunoglobulin (Ig1) domain of neural cell adhesion molecule 2 (NCAM2/OCAM/RNCAM) is presented at a resolution of 2.7 angstrom. NCAM2 is a member of the immunoglobulin superfamily of ce... Specific Interdomain Synergy in the UapA Transporter Determines Its Unique Specificity for Uric Acid among NAT Carriers [作者：Papageorgiou, L; Gournas, C; Vlanti, A; Amillis, S; Pantazopoulou, A; Diallinas, G,期刊：Journal of Molecular Biology, 页码：1121-1135 , 文章类型： Article，,卷期：2008年382-5] UapA, a uric acid-xanthine permease of Aspergillus nidulans, has been used as a prototype to study structure-function relationships in the ubiquitous nucleobase-ascorbate transporter (NAT) family. Using novel genetic scr... Efficient Selection of DARPins with Sub-nanomolar Affinities using SRP Phage Display [作者：Steiner, D; Forrer, P; Pluckthun, A,期刊：Journal of Molecular Biology, 页码：1211-1227 , 文章类型： Article，,卷期：2008年382-5] There is an ever-increasing demand to select specific, high-affinity binding molecules against targets of biomedical interest. The success of such selections depends strongly on the design and functional diversity of the... Evidence for Stepwise Formation of Amyloid Fibrils by the Mouse Prion Protein [作者：Jain, S; Udgaonkar, JB,期刊：Journal of Molecular Biology, 页码：1228-1241 , 文章类型： Article，,卷期：2008年382-5] The full-length Mouse prion protein, moPrP, is shown to form worm-like amyloid fibrils at pH 2 in the presence of 0.15 M NaCl, in a slow process that is accelerated at higher temperatures. Upon reduction in pH to 2, nati...