- Structural and Kinetic Analysis of Pyrrolidine-Based Inhibitors of the Drug-Resistant Ile84Val Mutant of HIV-1 Protease
[作者:Bottcher, J; Blum, A; Heine, A; Diederich, WE; Klebe, G,期刊:Journal of Molecular Biology, 页码:347-357 , 文章类型: Article,,卷期:2008年383-2]
- Human immunodeficiency virus (HIV) protease is a well-established drug target in HIV chemotherapy. However, continuously increasing resistance towards approved drugs inevitably requires the development of new inhibitors ...
- Denaturational Stress Induces Formation of Zinc-Deficient Monomers of Cu,Zn Superoxide Dismutase: Implications for Pathogenesis in Amyotrophic Lateral Sclerosis
[作者:Mulligan, VK; Kerman, A; Ho, S; Chakrabartty, A,期刊:Journal of Molecular Biology, 页码:424-436 , 文章类型: Article,,卷期:2008年383-2]
- Mutations in the Cu,Zn superoxide dismutase (SOD1) cause a subset of amyotrophic lateral sclerosis cases. SOD1 is a homodimer in which each monomer binds one copper atom and one zinc atom. Mutation is believed to increas...
- Crystal Structure of Escherichia coli Rnk, a New RNA Polymerase-Interacting Protein
[作者:Lamour, V; Rutherford, ST; Kuznedelov, K; Ramagopal, UA; Gourse, RL; Severinov, K; Darst, SA,期刊:Journal of Molecular Biology, 页码:367-379 , 文章类型: Article,,卷期:2008年383-2]
- Sequence-based searches identified a new family of genes in proteobacteria, named rnk, which shares high sequence similarity with the C-terminal domains of the Gre factors (GreA and GreB) and the Thermus/Deinococcus anti...
- Folding Mechanism of Reduced Cytochrome c: Equilibrium and Kinetic Properties in the Presence of Carbon Monoxide
[作者:Latypov, RF; Maki, K; Cheng, H; Luck, SD; Roder, H,期刊:Journal of Molecular Biology, 页码:437-453 , 文章类型: Article,,卷期:2008年383-2]
- Despite close structural similarity, the ferric and ferrous forms of cytochrome c differ greatly in terms of their ligand binding properties, stability, folding, and dynamics. The reduced heme iron binds diatomic ligands...
- Synonymous Mutations and Ribosome Stalling Can Lead to Altered Folding Pathways and Distinct Minima
[作者:Tsai, CJ; Sauna, ZE; Kimchi-Sarfaty, C; Ambudkar, SV; Gottesman, MM; Nussinov, R,期刊:Journal of Molecular Biology, 页码:281-291 , 文章类型: Review,,卷期:2008年383-2]
- How can we understand a case in which a given amino acid sequence folds into structurally and functionally distinct molecules? Synonymous single-nucleoticle polymorphisms in the MDR1 (multidrug resistance 1 or ABCB1) gen...
- Domain II of Thermus thermophilus Ribosomal Protein L1 Hinders Recognition of Its mRNA
[作者:Tishchenko, S; Kljashtorny, V; Kostareva, O; Nevskaya, N; Nikulin, A; Gulak, P; Piendl, W; Garber, M; Nikonov, S,期刊:Journal of Molecular Biology, 页码:301-305 , 文章类型: Article,,卷期:2008年383-2]
- The two-domain ribosomal protein L1 has a dual function as a primary rRNA-binding ribosomal protein and as a translational repressor that binds its own mRNA. Here, we report the crystal structure of a complex between the...
- Substrate Preference of Transglutaminase 2 Revealed by Logistic Regression Analysis and Intrinsic Disorder Examination
[作者:Csosz, E; Bagossi, P; Nagy, Z; Dosztanyi, Z; Simon, I; Fesus, L,期刊:Journal of Molecular Biology, 页码:390-402 , 文章类型: Article,,卷期:2008年383-2]
- Tissue transglutaminase (TG2) catalyzes the Ca2+-dependent posttranslational modification of proteins via formation of isopeptide bonds between their glutamine and lysine residues. Although substrate specificity of TG2 h...
- Solution Structure of a Cyanobacterial Phytochrome GAF Domain in the Red-Light-Absorbing Ground State
[作者:Cornilescu, G; Ulijasz, AT; Cornilescu, CC; Markley, JL; Vierstra, RD,期刊:Journal of Molecular Biology, 页码:403-413 , 文章类型: Article,,卷期:2008年383-2]
- The unique photochromic absorption behavior of phytochromes (Phys) depends on numerous reversible interactions between the bilin chromophore and the associated polypeptide. To help define these dynamic interactions, we d...
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