- Flagellar Rotation in the Archaeon Halobacterium salinarum Depends on ATP
[作者:Streif, S; Staudinger, WF; Marwan, W; Oesterhelt, D,期刊:Journal of Molecular Biology, 页码:1-8 , 文章类型: Article,,卷期:2008年384-1]
- Halobacterium salinarum swims with the help of a polarly inserted flagellar bundle. In energized cells, the flagellar motors rotate continuously, occasionally switching the rotational sense. Starving cells become immotil...
- The Expression Level of the Chromatin-Associated HMGB1 Protein Influences Growth, Stress Tolerance, and Transcriptome in Arabidopsis
[作者:Lildballe, DL; Pedersen, DS; Kalamajka, R; Emmersen, J; Houben, A; Grasser, KD,期刊:Journal of Molecular Biology, 页码:9-21 , 文章类型: Article,,卷期:2008年384-1]
- High mobility group (HMG) proteins of the HMGB family are small and relatively abundant chromatin-associated proteins. As architectural factors, the HMGB proteins are involved in the regulation of transcription and other...
- Structural Basis of beta-Catenin Recognition by Tax-interacting Protein-1
[作者:Zhang, JX; Yan, XJ; Shi, CW; Yang, X; Guo, Y; Tian, CL; Long, JF; Shen, YQ,期刊:Journal of Molecular Biology, 页码:255-263 , 文章类型: Article,,卷期:2008年384-1]
- Tax-interacting protein-1 (TIP-1) is an unusual signaling protein, containing a single PDZ domain. TIP-1 is able to bind beta-catenin with high affinity and thus inhibit its transcriptional activity. The high-resolution ...
- Single-Molecule Fluorescence Resonance Energy Transfer Assays Reveal Heterogeneous Folding Ensembles in a Simple RNA Stem-Loop
[作者:Gell, C; Sabir, T; Westwood, J; Rashid, A; Smith, DAM; Harris, SA; Stockley, PG,期刊:Journal of Molecular Biology, 页码:264-278 , 文章类型: Article,,卷期:2008年384-1]
- We have examined the folding ensembles present in solution for a series of RNA oligonucleotides that encompass the replicase translational operator stem-loop of the RNA bacteriophage MS2. Single-molecule (SM) fluorescenc...
- Induction of MuRF1 Is Essential for TNF-alpha-Induced Loss of Muscle Function in Mice
[作者:Adams, V; Mangner, N; Gasch, A; Krohne, C; Gielen, S; Hirner, S; Thierse, HJ; Witt, CC; Linke, A; Schuler, G; Labeit, S,期刊:Journal of Molecular Biology, 页码:48-59 , 文章类型: Article,,卷期:2008年384-1]
- Background: Humoral circulating inflammatory cytokines such as tumor necrosis factor alpha (TNF-alpha) can impair skeletal muscle contractility. Furthermore, TNF-alpha expression correlates with elevated levels of atrogi...
- Genetic and Structural Characterization of an L201 P Global Suppressor Substitution in TEM-1 beta-Lactamase
[作者:Marciano, DC; Pennington, JM; Wang, X; Wang, J; Chen, Y; Thomas, VL; Shoichet, BK; Palzkill, T,期刊:Journal of Molecular Biology, 页码:151-164 , 文章类型: Article,,卷期:2008年384-1]
- TEM-1 beta-lactamase confers bacterial resistance to penicillin antibiotics and has acquired mutations that permit the enzyme to hydrolyze extended-spectrum cephalosporins or to avoid inactivation by beta-lactamase inhib...
- Structure of Bacterial Glutathione-S-Transferase Maleyl Pyruvate Isomerase and Implications for Mechanism of Isomerisation
[作者:Marsh, M; Shoemark, DK; Jacob, A; Robinson, C; Cahill, B; Zhou, NY; Williams, PA; Hadfield, AT,期刊:Journal of Molecular Biology, 页码:165-177 , 文章类型: Article,,卷期:2008年384-1]
- Maleyl pyruvate isomerase (MPI) is a bacterial glutathione S-transferase (GST) from the pathway for degradation of naphthalene via gentisate that enables the bacterium Ralstonia to use polyaromatic hydrocarbons as a sole...
- Understanding the Organisation and Role of Myosin Binding Protein C in Normal Striated Muscle by Comparison with MyBP-C Knockout Cardiac Muscle
[作者:Luther, PK; Bennett, PM; Knupp, C; Craig, R; Padron, R; Harris, SP; Patel, J; Moss, RL,期刊:Journal of Molecular Biology, 页码:60-72 , 文章类型: Article,,卷期:2008年384-1]
- Myosin binding protein C (MyBP-C) is a component of the thick filament of striated muscle. The importance of this protein is revealed by recent evidence that mutations in the cardiac gene are a major cause of familial hy...
- Three-dimensional Structures of Pseudomonas aeruginosa PvcA and PvcB, Two Proteins Involved in the Synthesis of 2-Isocyano-6,7-dihydroxycoumarin
[作者:Drake, EJ; Gulick, AM,期刊:Journal of Molecular Biology, 页码:193-205 , 文章类型: Article,,卷期:2008年384-1]
- The pvcABCD operon of Pseudomonas aeruginosa encodes four proteins (PA2254, PA2255, PA2256, and PA2257) that form a cluster that is responsible for the synthesis of a cyclized isocyano derivative of tyrosine. These prote...
- Computational Redesign of a Protein-Protein Interface for High Affinity and Binding Specificity Using Modular Architecture and Naturally Occurring Template Fragments
[作者:Potapov, V; Reichmann, D; Abramovich, R; Filchtinski, D; Zohar, N; Ben Halevy, D; Edelman, M; Sobolev, V; Schreiber, G,期刊:Journal of Molecular Biology, 页码:109-119 , 文章类型: Article,,卷期:2008年384-1]
- A new method is presented for the redesign of protein-protein interfaces, resulting in specificity of the designed pair while maintaining high affinity. The design is based on modular interface architecture and was carri...
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