- Alternative Conformations of the x Region of Human Protein Disulphide-Isomerase Modulate Exposure of the Substrate Binding b' Domain
[作者:Nguyen, VD; Wallis, K; Howard, MJ; Haapalainen, AM; Salo, KEH; Saaranen, MJ; Sidhu, A; Wierenga, RK; Freedman, RB; Ruddock, LW; Williamson, RA,期刊:Journal of Molecular Biology, 页码:1144-1155 , 文章类型: Article,,卷期:2008年383-5]
- Protein disulphide isomerase (PDI) is a key multi-domain protein folding catalyst in the endoplasmic reticulum. The b' domain of PDI is essential for the non-covalent binding of incompletely folded protein substrates. Ea...
- Artificial Binding Proteins (Affitins) as Probes for Conformational Changes in Secretin PulD
[作者:Krehenbrink, M; Chami, M; Guilvout, I; Alzari, PM; Pecorari, F; Pugsley, AP,期刊:Journal of Molecular Biology, 页码:1058-1068 , 文章类型: Article,,卷期:2008年383-5]
- The DNA-binding protein Sac7d was previously modified to bind with high affinity to the N domain of the outer membrane secretin PulD from the bacterium Klebsiella oxytoca. Here, we show that binding of the Sac7d derivati...
- Solution Structure and Characterization of the DNA-Binding Activity of the B3BP-Smr Domain
[作者:Diercks, T; Eiso, AB; Daniels, MA; de Jong, RN; Besseling, R; Kaptein, R; Folkers, GE,期刊:Journal of Molecular Biology, 页码:1156-1170 , 文章类型: Article,,卷期:2008年383-5]
- The MutS1 protein recognizes unpaired bases and initiates mismatch repair, which are essential for high-fidelity DNA replication. The homologous MutS2 protein does not contribute to mismatch repair, but suppresses homolo...
- A Single Mutation in the IF3 N-Terminal Domain Perturbs the Fidelity of Translation Initiation at Three Levels
[作者:Maar, D; Liveris, D; Sussman, JK; Ringquist, S; Moll, I; Heredia, N; Kil, A; Blasi, U; Schwartz, I; Simons, RW,期刊:Journal of Molecular Biology, 页码:937-944 , 文章类型: Article,,卷期:2008年383-5]
- Bacterial translation initiation factor 3 (IF3) is involved in the fidelity of translation initiation at several levels, including start-codon discrimination, mRNA translation, and initiator-tRNA selection. The IF3 C-ter...
- How the HIV-1 Nucleocapsid Protein Binds and Destabilises the (-)Primer Binding Site During Reverse Transcription
[作者:Bourbigot, S; Ramalanjaona, N; Boudier, C; Salgado, GFJ; Roques, BP; Mely, Y; Bouaziz, S; Morellet, N,期刊:Journal of Molecular Biology, 页码:1112-1128 , 文章类型: Article,,卷期:2008年383-5]
- The human immunodeficiency virus type 1 nucleocapsid protein (NCp7) plays an important role in the second strand transfer during reverse transcription. It promotes annealing of the 18-nucleotide complementary DNA primer-...
- Reconstituting Initial Events during the Assembly of Apolipoprotein B-Containing Lipoproteins in a Cell-Free System
[作者:Jiang, ZG; Liu, YH; Hussain, MM; Atkinson, D; McKnight, CJ,期刊:Journal of Molecular Biology, 页码:1181-1194 , 文章类型: Article,,卷期:2008年383-5]
- The synthesis of apolipoprotein B (apoB) dictates the formation of chylomicrons and very low-density lipoproteins, two major lipoprotein precursors in the human plasma. Despite its biological significance, the mechanism ...
- Thermodynamics, Kinetics, and Salt dependence of Folding of YopM, a Large Leucine-rich Repeat Protein
[作者:Kloss, E; Barrick, D,期刊:Journal of Molecular Biology, 页码:1195-1209 , 文章类型: Article,,卷期:2008年383-5]
- Small globular proteins have many contacts between residues that are distant in primary sequence. These contacts create a complex network between sequence-distant segments of secondary structure, which may be expected to...
- Transcriptional Activation of Human Matrix Metalloproteinase-9 Gene Expression by Multiple Co-activators
[作者:Zhao, XY; Benveniste, EN,期刊:Journal of Molecular Biology, 页码:945-956 , 文章类型: Article,,卷期:2008年383-5]
- Matrix metalloproteinase-9 (MMP-9), a proteolytic enzyme for matrix proteins, chemokines and cytokines, is a major target in cancer and autoimmune diseases, since it is aberrantly upregulated. To control MMP-9 expression...
|