- Evidence for the Oligomeric State of 'Elastic' Titin in Muscle Sarcomeres
[作者：Houmeida, A; Baron, A; Keen, J; Khan, GN; Knight, PJ; Stafford, WF; Thirumurugan, K; Thompson, B; Tskhovrebova, L; Trinick, J,期刊：Journal of Molecular Biology, 页码：299-312 , 文章类型： Article，,卷期：2008年384-2]
- The,giant protein titin has important roles in muscle sarcomere integrity, elasticity and contractile activity. The key role in elasticity was highlighted in recent years by single-molecule mechanical studies, which show...
- Triggering of Apoptosis by Puma Is Determined by the Threshold Set by Prosurvival Bcl-2 Family Proteins
[作者：Callus, BA; Moujallad, DM; Silke, J; Gerl, R; Jabbour, AM; Ekert, PG; Vaux, DL,期刊：Journal of Molecular Biology, 页码：313-323 , 文章类型： Article，,卷期：2008年384-2]
- Puma (p53 upregulated modulator of apoptosis) belongs to the BH3 (Bcl2 homology 3)-ordy protein family of apoptotic regulators. Its expression is induced by various apoptotic stimuli, including irradiation and cytokine w...
- The Filamentous Actin Cross-Linking/Bundling Activity of Mammalian Formins
[作者：Esue, O; Harris, ES; Higgs, HN; Wirtz, D,期刊：Journal of Molecular Biology, 页码：324-334 , 文章类型： Article，,卷期：2008年384-2]
- Formins are multidomain proteins that regulate actin filament dynamics and are defined by the formin homology 2 domain. Biochemical assays suggest that mammalian formins display actin-filament nucleation, severing, and b...
- Assembling the Human IFN-beta Enhanceosome in Solution
[作者：Dragan, AI; Carrillo, R; Gerasimova, TI; Privalov, PL,期刊：Journal of Molecular Biology, 页码：335-348 , 文章类型： Article，,卷期：2008年384-2]
- Assembly of interferon-beta enhanceosome from its individual protein components and of enhancer DNA has been studied in solution using a combination of fluorescence anisotropy, microcalorimetry, and CD titration. It was ...
- Solution NMR Structure of Putidaredoxin-Cytochrome P450cam Complex via a Combined Residual Dipolar Coupling-Spin Labeling Approach Suggests a Role for Trp106 of Putidaredoxin in Complex Formation
[作者：Zhang, W; Pochapsky, SS; Pochapsky, TC; Jain, NU,期刊：Journal of Molecular Biology, 页码：349-363 , 文章类型： Article，,卷期：2008年384-2]
- The 58-kDa complex formed between the [2Fe-2S] ferredoxin, puticlaredoxin (Pdx), and cytochrome P450cam (CYP101) from the bacterium Pseudomonas pidida has been investigated by high-resolution solution NMR spectroscopy. P...
- Structure of a sigma(28)-Regulated Nonflagellar Virulence Protein from Campylobacter jejuni
[作者：Yokoyama, T; Paek, S; Ewing, CP; Guerry, P; Yeo, HJ,期刊：Journal of Molecular Biology, 页码：364-376 , 文章类型： Article，,卷期：2008年384-2]
- Campylobacter jejuni, a Gram-negative motile bacterium, is a leading cause of human gastrointestinal infections. Although the mechanism of C. jejuni-mediated enteritis appears to be multifactorial, flagella play complex ...
- Structural Details of HIV-1 Recognition by the Broadly Neutralizing Monoclonal Antibody 2F5: Epitope Conformation, Antigen-Recognition Loop Mobility, and Anion-Binding Site
[作者：Julien, JP; Bryson, S; Nieva, JL; Pai, EF,期刊：Journal of Molecular Biology, 页码：377-392 , 文章类型： Article，,卷期：2008年384-2]
- 2F5 is a monoclonal antibody with potent and broadly neutralizing activity against HIV-1. It targets the membrane-proximal external region (MPER) of the gp41 subunit of the envelope glycoprotein and interferes with the p...
- The 1.8-angstrom Crystal Structure of alpha(1)-Acid Glycoprotein (Orosomucoid) Solved by UV RIP Reveals the Broad Drug-Binding Activity of This Human Plasma Lipocalin
[作者：Schonfeld, DL; Ravelli, RBG; Mueller, U; Skerra, A,期刊：Journal of Molecular Biology, 页码：393-405 , 文章类型： Article，,卷期：2008年384-2]
- alpha(1)-Acid glycoprotein (AGP) is an important drug-binding protein in human plasma and, as an acute-phase protein, it has a strong influence on pharmacokinetics and pharmacodynamics of many pharmaceuticals. We report ...
- Histidine Kinase Regulation by a Cyclophilin-like Inhibitor
[作者：Jacques, DA; Langley, DB; Jeffries, CM; Cunningham, KA; Burkholder, WF; Guss, JM; Trewhella, J,期刊：Journal of Molecular Biology, 页码：422-435 , 文章类型： Article，,卷期：2008年384-2]
- The sensor histidine kinase A (KinA) from Bacillus subtilis triggers a phosphorelay that activates sporulation. The antikinase KipI prevents sporulation by binding KinA and inhibiting the autophosphorylation reaction. Us...
- Crystal Structure of the NanB Sialidase from Streptococcus pneumoniae
[作者：Xu, GG; Potter, JA; Russell, RJM; Oggioni, MR; Andrew, PW; Taylor, GL,期刊：Journal of Molecular Biology, 页码：436-449 , 文章类型： Article，,卷期：2008年384-2]
- The Streptococcus pneumoniae genomes encode up to three sialidases (or neuraminidases), NanA, NanB and NanC, which are believed to be involved in removing sialic acid from host cell surface glycans, thereby promoting col...
- Structure of the Cyclomodulin Cif from Pathogenic Escherichia coli
[作者：Hsu, Y; Jubelin, G; Taieb, F; Nougayrede, JP; Oswald, E; Stebbins, CE,期刊：Journal of Molecular Biology, 页码：465-477 , 文章类型： Article，,卷期：2008年384-2]
- Bacterial pathogens have evolved a sophisticated arsenal of virulence factors to modulate host cell biology. Enteropathogenic and enterohemorrhagic Escherichia coli (EPEC and EHEC) use a type III protein secretion system...
- Structural Insights into the Catalytic Mechanism of the Bacterial Class B Phosphatase AphA Belonging to the DDDD Superfamily of Phosphohydrolases
[作者：Leone, R; Cappelletti, E; Benvenuti, M; Lentini, G; Thaller, MC; Mangani, S,期刊：Journal of Molecular Biology, 页码：478-488 , 文章类型： Article，,卷期：2008年384-2]
- AphA is a magnesium-dependent, bacterial class B acid phosphatase that catalyzes the hydrolysis of a variety of phosphoester substrates and belongs to the DDDD superfamily of phosphohydrolases. The recently reported crys...
- Structural Analysis of the Heterodimeric Type IIS Restriction Endonuclease R.BspD6I Acting as a Complex between a Monomeric Site-specific Nickase and a Catalytic Subunit
[作者：Kachalova, GS; Rogulin, EA; Yunusova, AK; Artyukh, RI; Perevyazova, TA; Matvienko, NI; Zheleznaya, LA; Bartunik, HD,期刊：Journal of Molecular Biology, 页码：489-502 , 文章类型： Article，,卷期：2008年384-2]
- The heterodimeric restriction endonuclease R.BspD61 from Bacillus species D6 recognizes a pseudosymmetric sequence and cuts both DNA strands outside the recognition sequence. The large subunit, Nt.BspD6I, acts as a type ...
- An Intrinsic Degradation Tag on the ClpA C-Terminus Regulates the Balance of ClpAP Complexes with Different Substrate Specificity
[作者：Maglica, Z; Striebel, F; Weber-Ban, E,期刊：Journal of Molecular Biology, 页码：503-511 , 文章类型： Article，,卷期：2008年384-2]
- ATP-dependent protein degradation in bacteria is carried out by barrel-shaped proteases architecturally related to the proteasome. In Escherichia coli, CIpP interacts with two alternative ATPases, ClpA or ClpX, to form a...
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