- Architectural roles of multiple chromatin insulators at the human apolipoprotein gene cluster
[作者:Mishiro, T; Ishihara, K; Hino, S; Tsutsumi, S; Aburatani, H; Shirahige, K; Kinoshita, Y; Nakao, M,期刊:EMBO journal, 页码:1234-1245 , 文章类型: Article,,卷期:2009年28-9]
- Long-range regulatory elements and higher-order chromatin structure coordinate the expression of multiple genes in cluster, and CTCF/cohesin-mediated chromatin insulator may be a key in this regulation. The human apolipo...
- 18S rRNA processing requires base pairings of snR30 H/ACA snoRNA to eukaryote-specific 18S sequences
[作者:Fayet-Lebaron, E; Atzorn, V; Henry, Y; Kiss, T,期刊:EMBO journal, 页码:1260-1270 , 文章类型: Article,,卷期:2009年28-9]
- The H/ACA RNAs represent an abundant, evolutionarily conserved and functionally diverse class of non-coding RNAs. Many H/ACA RNAs direct pseudouridylation of rRNAs and snRNAs, while members of the rapidly growing group o...
- Ubiquitin-mediated proteolysis of HuR by heat shock
[作者:Abdelmohsen, K; Srikantan, S; Yang, XL; Lal, A; Kim, HH; Kuwano, Y; Galban, S; Becker, KG; Kamara, D; de Cabo, R; Gorospe, M,期刊:EMBO journal, 页码:1271-1282 , 文章类型: Article,,卷期:2009年28-9]
- The RNA-binding protein HuR regulates the stability and translation of numerous mRNAs encoding stress-response and proliferative proteins. Although its post-transcriptional influence has been linked primarily to its cyto...
- Termination of NF-kappa B activity through a gammaherpesvirus protein that assembles an EC5S ubiquitin-ligase
[作者:Rodrigues, L; Filipe, J; Seldon, MP; Fonseca, L; Anrather, J; Soares, MP; Simas, JP,期刊:EMBO journal, 页码:1283-1295 , 文章类型: Article,,卷期:2009年28-9]
- Host colonisation by lymphotropic gammaherpesviruses depends critically on the expansion of viral genomes in germinal centre (GC) B cells. Yet, host and virus molecular mechanisms involved in driving such proliferation r...
- ER stress protects from retinal degeneration
[作者:Mendes, CS; Levet, C; Chatelain, G; Dourlen, P; Fouillet, A; Dichtel-Danjoy, ML; Gambis, A; Ryoo, HD; Steller, H; Mollereau, B,期刊:EMBO journal, 页码:1296-1307 , 文章类型: Article,,卷期:2009年28-9]
- The unfolded protein response (UPR) is a specific cellular process that allows the cell to cope with the overload of unfolded/misfolded proteins in the endoplasmic reticulum (ER). ER stress is commonly associated with de...
- The mechano-activated K+ channels TRAAK and TREK-1 control both warm and cold perception
[作者:Noel, J; Zimmermann, K; Busserolles, J; Deval, E; Alloui, A; Diochot, S; Guy, N; Borsotto, M; Reeh, P; Eschalier, A; Lazdunski, M,期刊:EMBO journal, 页码:1308-1318 , 文章类型: Article,,卷期:2009年28-9]
- The sensation of cold or heat depends on the activation of specific nerve endings in the skin. This involves heat-and cold-sensitive excitatory transient receptor potential (TRP) channels. However, we show here that the ...
- Mst1 controls lymphocyte trafficking and interstitial motility within lymph nodes
[作者:Katagiri, K; Katakai, T; Ebisuno, Y; Ueda, Y; Okada, T; Kinashi, T,期刊:EMBO journal, 页码:1319-1331 , 文章类型: Article,,卷期:2009年28-9]
- The regulation of lymphocyte adhesion and migration plays crucial roles in lymphocyte trafficking during immunosurveillance. However, our understanding of the intracellular signalling that regulates these processes is st...
- The structural basis for peptide selection by the transport receptor OppA
[作者:Berntsson, RPA; Doeven, MK; Fusetti, F; Duurkens, RH; Sengupta, D; Marrink, SJ; Thunnissen, AMWH; Poolman, B; Slotboom, DJ,期刊:EMBO journal, 页码:1332-1340 , 文章类型: Article,,卷期:2009年28-9]
- Oligopeptide-binding protein A (OppA) from Lactococcus lactis binds peptides of an exceptionally wide range of lengths (4-35 residues), with no apparent sequence preference. Here, we present the crystal structures of Opp...
- The structure of Atg4B-LC3 complex reveals the mechanism of LC3 processing and delipidation during autophagy
[作者:Satoo, K; Noda, NN; Kumeta, H; Fujioka, Y; Mizushima, N; Ohsumi, Y; Inagaki, F,期刊:EMBO journal, 页码:1341-1350 , 文章类型: Article,,卷期:2009年28-9]
- Atg8 is conjugated to phosphatidylethanolamine (PE) by ubiquitin-like conjugation reactions. Atg8 has at least two functions in autophagy: membrane biogenesis and target recognition. Regulation of PE conjugation and deco...
- RNA helicase module in an acetyltransferase that modifies a specific tRNA anticodon
[作者:Chimnaronk, S; Suzuki, T; Manita, T; Ikeuchi, Y; Yao, M; Suzuki, T; Tanaka, I,期刊:EMBO journal, 页码:1362-1373 , 文章类型: Article,,卷期:2009年28-9]
- Post-transcriptional RNA modifications in the anticodon of transfer RNAs frequently contribute to the high fidelity of protein synthesis. In eubacteria, two genome-encoded transfer RNA (tRNA) species bear the same CAU se...
- The human kinetochore proteins Nnf1R and Mcm21R are required for accurate chromosome segregation (vol 25, pg 4033, 2006)
[作者:McAinsh, AD; Meraldi, P; Draviam, VM; Toso, A; Sorger, PK,期刊:EMBO journal, 页码:1374-1374 , 文章类型: Correction,,卷期:2009年28-9]
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- Acid sphingomyelinase activity triggers microparticle release from glial cells (vol 28, pg 1043, 2009)
[作者:Bianco, F; Perrotta, C; Novellino, L; Francolini, M; Riganti, L; Menna, E; Saglietti, L; Schuchman, EH; Furlan, R; Clementi, E; Matteoli, M; Verderio, C,期刊:EMBO journal, 页码:1374-1374 , 文章类型: Correction,,卷期:2009年28-9]
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- Bend into shape
[作者:de Boer, PAJ,期刊:EMBO journal, 页码:1193-1194 , 文章类型: Article,,卷期:2009年28-9]
- Bacteria come in a variety of shapes, as most species elaborate on the 'default' sphere to resemble ovoids, rods, bend rods, spirals, branched filaments or other more complicated forms. How cells that are under considera...
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