- Nonconformity in ubiquitin compliance
[作者：Ziv, I; Kleifeld, O; Glickman, M,期刊：EMBO journal, 页码：1825-1827 , 文章类型： Article，,卷期：2009年28-13]
- Polyubiquitin (polyUb) is a diverse signal in terms of both chain length and linkage type (Ikeda and Dikic, 2008). Chains can be formed through covalent conjugation of ubiquitin (Ub) to any of the seven lysine residues o...
- A PH domain within OCRL bridges clathrin-mediated membrane trafficking to phosphoinositide metabolism
[作者：Mao, YX; Balkin, DM; Zoncu, R; Erdmann, KS; Tomasini, L; Hu, FH; Jin, MM; Hodsdon, ME; De Camilli, P,期刊：EMBO journal, 页码：1831-1842 , 文章类型： Article，,卷期：2009年28-13]
- OCRL, whose mutations are responsible for Lowe syndrome and Dent disease, and INPP5B are two similar proteins comprising a central inositol 5-phosphatase domain followed by an ASH and a RhoGAP-like domain. Their divergen...
- JNK signalling modulates intestinal homeostasis and tumourigenesis in mice
[作者：Sancho, R; Nateri, AS; de Vinuesa, AG; Aguilera, C; Nye, E; Spencer-Dene, B; Behrens, A,期刊：EMBO journal, 页码：1843-1854 , 文章类型： Article，,卷期：2009年28-13]
- Wnt signalling is a crucial signalling pathway controlling intestinal homeostasis and cancer. We show here that the JNK MAP kinase pathway and one of its most important substrates, the AP-1 transcription factor c-Jun, mo...
- The fungal RNA-binding protein Rrm4 mediates long-distance transport of ubi1 and rho3 mRNAs
[作者：Konig, J; Baumann, S; Koepke, J; Pohlmann, T; Zarnack, K; Feldbrugge, M,期刊：EMBO journal, 页码：1855-1866 , 文章类型： Article，,卷期：2009年28-13]
- Cytoskeletal transport promotes polar growth in filamentous fungi. In Ustilago maydis, the RNA-binding protein Rrm4 shuttles along microtubules and is crucial for polarity in infectious filaments. Mutations in the RNA-bi...
- S5a promotes protein degradation by blocking synthesis of nondegradable forked ubiquitin chains
[作者：Kim, HT; Kim, KP; Uchiki, T; Gygi, SP; Goldberg, AL,期刊：EMBO journal, 页码：1867-1877 , 文章类型： Article，,卷期：2009年28-13]
- Ubiquitin (Ub)-protein conjugates formed by purified ring-finger or U-box E3s with the E2, UbcH5, resist degradation and disassembly by 26S proteasomes. These chains contain multiple types of Ub forks in which two Ub's a...
- The epidermal differentiation-associated Grainyhead gene Get1/Grhl3 also regulates urothelial differentiation
[作者：Yu, ZQ; Mannik, J; Soto, A; Lin, KK; Andersen, B,期刊：EMBO journal, 页码：1890-1903 , 文章类型： Article，,卷期：2009年28-13]
- Skin and bladder epithelia form effective permeability barriers through the activation of distinct differentiation gene programs. Using a genome-wide gene-expression study, we identified transcriptional regulators whose ...
- Rescue of key features of the p63-null epithelial phenotype by inactivation of Ink4a and Arf
[作者：Su, XH; Cho, MS; Gi, YJ; Ayanga, BA; Sherr, CJ; Flores, ER,期刊：EMBO journal, 页码：1904-1915 , 文章类型： Article，,卷期：2009年28-13]
- Mice lacking p63 cannot form skin, exhibit craniofacial and skeletal defects, and die soon after birth. The p63 gene regulates a complex network of target genes, and disruption of p63 has been shown to affect the mainten...
- The Apaf-1 center dot Kprocaspase-9 apoptosome complex functions as a proteolytic-based molecular timer
[作者：Malladi, S; Challa-Malladi, M; Fearnhead, HO; Bratton, SB,期刊：EMBO journal, 页码：1916-1925 , 文章类型： Article，,卷期：2009年28-13]
- During stress-induced apoptosis, the initiator caspase-9 is activated by the Apaf-1 apoptosome and must remain bound to retain significant catalytic activity. Nevertheless, in apoptotic cells the vast majority of process...
- MDM4 (MDMX) localizes at the mitochondria and facilitates the p53-mediated intrinsic-apoptotic pathway
[作者：Mancini, F; Di Conza, G; Pellegrino, M; Rinaldo, C; Prodosmo, A; Giglio, S; D'Agnano, I; Florenzano, F; Felicioni, L; Buttitta, F; Marchetti, A; Sacchi, A; Pontecorvi, A; Soddu, S; Moretti, F,期刊：EMBO journal, 页码：1926-1939 , 文章类型： Article，,卷期：2009年28-13]
- MDM4 is a key regulator of p53, whose biological activities depend on both transcriptional activity and transcription-independent mitochondrial functions. MDM4 binds to p53 and blocks its transcriptional activity; howeve...
- Noc protein binds to specific DNA sequences to coordinate cell division with chromosome segregation
[作者：Wu, LJ; Ishikawa, S; Kawai, Y; Oshima, T; Ogasawara, N; Errington, J,期刊：EMBO journal, 页码：1940-1952 , 文章类型： Article，,卷期：2009年28-13]
- Coordination of chromosome segregation and cytokinesis is crucial for efficient cell proliferation. In Bacillus subtilis, the nucleoid occlusion protein Noc protects the chromosomes by associating with the chromosome and...
- Molecular recognition of histone lysine methylation by the Polycomb group repressor dSfmbt
[作者：Grimm, C; Matos, R; Ly-Hartig, N; Steuerwald, U; Lindner, D; Rybin, V; Muller, J; Muller, CW,期刊：EMBO journal, 页码：1965-1977 , 文章类型： Article，,卷期：2009年28-13]
- Polycomb group (PcG) proteins repress transcription by modifying chromatin structure in target genes. dSfmbt is a subunit of the Drosophila melanogaster PcG protein complex PhoRC and contains four malignant brain tumour ...
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