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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共10条记录   IL-33: a promising therapeutic target for rheumatoid arthritis? [作者：Yuan, FL; Li, X; Lu, WG; Li, CW; Xu, RS; Dong, JA,期刊：Expert Opinion on Therapeutic Targets, 页码：529-534 , 文章类型： Editorial Material，,卷期：2011年15-5] Cytokine-mediated immunity plays a crucial role in the pathogenesis of various autoimmune diseases, including rheumatoid arthritis (RA). Recently, the IL-1-family-related cytokine, IL-33, was detected at high levels in e... Neurobiological aspects of Alzheimer's disease [作者：Chopra, K; Misra, S; Kuhad, A,期刊：Expert Opinion on Therapeutic Targets, 页码：535-555 , 文章类型： Review，,卷期：2011年15-5] Areas covered: The various neurobiological events associated with development of AD and the multiple treatment approaches for combating this disorder. Expert opinion: AD is a complex multifactorial disorder and thus a si... Targeting ligand-operated chaperone sigma-1 receptors in the treatment of neuropsychiatric disorders [作者：Hayashi, T; Tsai, SY; Mori, T; Fujimoto, M; Su, TP,期刊：Expert Opinion on Therapeutic Targets, 页码：557-577 , 文章类型： Review，,卷期：2011年15-5] Areas covered: Recent evidence that has shed light on sigma-1 receptor ligands, which may serve as a new class of antidepressants or neuroprotective agents. Sigma-1 receptors are novel ligand-operated molecular chaperone... Telomeres as targets for anticancer therapies [作者：Folini, M; Venturini, L; Cimino-Reale, G; Zaffaroni, N,期刊：Expert Opinion on Therapeutic Targets, 页码：579-593 , 文章类型： Review，,卷期：2011年15-5] Expert opinion: In this review, we summarize the available data concerning the therapeutic strategies proposed thus far and the current challenges posed for the development of innovative telomere-based therapeutic approa... Targeting aneuploid cancer cells [作者：Colombo, R; Moll, J,期刊：Expert Opinion on Therapeutic Targets, 页码：595-608 , 文章类型： Review，,卷期：2011年15-5] Areas covered: The molecular mechanisms that are at the origin of aneuploidy and their cellular consequences. Based on these new findings molecular targets have emerged which could lead to a specific treatment of at leas... Therapeutic targeting of tumor--stroma interactions [作者：Hiscox, S; Barrett-Lee, P; Nicholson, RI,期刊：Expert Opinion on Therapeutic Targets, 页码：609-621 , 文章类型： Review，,卷期：2011年15-5] Areas covered: This article reviews how key interactions between tumor epithelial cells and surrounding mesenchymal and immune cells can promote tumor progression and highlights molecular elements that might represent no... MicroRNAs in adipogenesis and as therapeutic targets for obesity [作者：Alexander, R; Lodish, H; Sun, L,期刊：Expert Opinion on Therapeutic Targets, 页码：623-636 , 文章类型： Review，,卷期：2011年15-5] Areas covered: This review provides a comprehensive view of miRNAs involved in adipogenesis, from mesenchymal stem cell lineage determination through terminal adipocyte differentiation. We also discuss the differential e... The therapeutic potential of targeting the glucagon-like peptide-2 receptor in gastrointestinal disease [作者：Hornby, PJ; Moore, BA,期刊：Expert Opinion on Therapeutic Targets, 页码：637-646 , 文章类型： Review，,卷期：2011年15-5] Areas covered: The clinical evidence for benefit in conditions requiring longer term treatment with GLP-2 receptor agonists, for example short bowel syndrome and inflammatory bowel disease. Benefits of short-term GLP-2 t... Mitochondrion: an emerging platform critical for host antiviral signaling [作者：Wang, C; Liu, XY; Wei, B,期刊：Expert Opinion on Therapeutic Targets, 页码：647-665 , 文章类型： Review，,卷期：2011年15-5] Areas covered: This review covers the literature of the past 6 years and summarizes the components, regulation and mechanisms of RLR signaling, highlighting the function and regulation of mitochondrial proteins, such as ... Targeting the toll-like receptor 7 pathway in asthma: a potential immunomodulatory approach? [作者：Antoniu, SA,期刊：Expert Opinion on Therapeutic Targets, 页码：667-669 , 文章类型： Editorial Material，,卷期：2011年15-5] In allergic airways, as in asthma, inflammation and impaired functioning of toll-like receptor 7 (TLR7) has been found. The augmentation of this receptor with agonist compounds resulted in bronchodilation and a switch of...