- Mechanism of metabolic activation and DNA adduct formation by the human carcinogen diethylstilbestrol: The defining link to natural estrogens
[作者:Saeed, M; Rogan, E; Cavalieri, E,期刊:International Journal of Cancer, 页码:1276-1284 , 文章类型: Article,,卷期:2009年124-6]
- Diethylstilbestrol (DES) is a human carcinogen, based on sufficient epidemiological evidence. DES is mainly metabolized to its catechol, 3'-hydroxyDES (3'-OH-DES), which can further oxidize to DES-3',4'-quinone (DES-3',4...
- Activator protein 2 alpha (AP2 alpha) suppresses 42 kDa C/CAAT enhancer binding protein alpha (p42(C/EBP alpha)) in head and neck squamous cell carcinoma
[作者:Bennett, KL; Romigh, T; Arab, K; Teresi, RE; Tada, Y; Eng, C; Plass, C,期刊:International Journal of Cancer, 页码:1285-1292 , 文章类型: Article,,卷期:2009年124-6]
- The tumor suppressor C/CAAT enhancer binding protein alpha (C/EBP alpha) is a transcription factor involved in cell cycle control and cellular differentiation. A recent study showed that C/EBP alpha is frequently downreg...
- How different are luminal A and basal breast cancers?
[作者:Bertucci, F; Finetti, P; Cervera, N; Charafe-Jauffret, E; Buttarelli, M; Jacquemier, J; Chaffanet, M; Maraninchi, D; Viens, P; Birnbaum, D,期刊:International Journal of Cancer, 页码:1338-1348 , 文章类型: Article,,卷期:2009年124-6]
- Heterogeneity of breast cancer makes its evolution difficult to predict, and its treatment far from being optimal. At least 5 main molecular subtypes exist. Two major subtypes are luminal A and basal subtypes, which have...
- Oviduct-specific glycoprotein is a molecular marker for invasion in endometrial tumorigenesis identified using a relevant mouse model
[作者:Wang, H; Joshi, A; Iaconis, L; Solomon, GL; Xiang, ZY; Verhage, HG; Douglas, W; Ronnett, BM; Ellenson, LH,期刊:International Journal of Cancer, 页码:1349-1357 , 文章类型: Article,,卷期:2009年124-6]
- The light microscopic distinction between complex atypical hyperplasia (CAH) and invasive endometrioid carcinoma (UEC) on endometrial sampling is problematic and often has significant clinical implications. Using mouse m...
- Effects of sunitinib on tumor hemodynamics and delivery of chemotherapy
[作者:Czabanka, M; Vinci, M; Heppner, F; Ullrich, A; Vajkoczy, P,期刊:International Journal of Cancer, 页码:1293-1300 , 文章类型: Article,,卷期:2009年124-6]
- Current clinical protocols favor a combination of antiangiogenic/antivascular compounds with classical chemotherapy. However, it remains unclear to what extent an antiangiogenic/antivascular therapy influences the delive...
- Sensitization of neuroblastoma cells for TRAIL-induced apoptosis by NF-kappa B inhibition
[作者:Ammann, JU; Haag, C; Kasperczyk, H; Debatin, KM; Fulda, S,期刊:International Journal of Cancer, 页码:1301-1311 , 文章类型: Article,,卷期:2009年124-6]
- The transcription factor nuclear factor-kappaB (NF-kappa B) plays a central role in stress-induced transcriptional activation and has been implicated in chemoresistance of cancers. In the present study, we investigated t...
- Dysregulated microRNAs and their predicted targets associated with endometrioid endometrial adenocarcinoma in Hong Kong women
[作者:Chung, TKH; Cheung, TH; Huen, NY; Wong, KWY; Lo, KWK; Yim, SF; Siu, NSS; Wong, YM; Tsang, PT; Pang, MW; Yu, MY; To, KF; Mok, SC; Wang, VW; Li, C; Cheung, AYK; Doran, G; Birrer, MJ; Smith, DI; Wong, YF,期刊:International Journal of Cancer, 页码:1358-1365 , 文章类型: Article,,卷期:2009年124-6]
- The objective of this study, a parallel study to global gene expression profiling, was to identify dysregulated microRNAs (miRNAs) associated with endometrioid endometrial adenocarcinoma (EEC), examine their correlation ...
- Loss of EphA2 receptor tyrosine kinase reduces Apc(Min/+) tumorigenesis
[作者:Bogan, C; Chen, J; O'Sullivan, MG; Cormier, RT,期刊:International Journal of Cancer, 页码:1366-1371 , 文章类型: Article,,卷期:2009年124-6]
- The Eph receptor A2 (EphA2) is overexpressed in a range of human epithelial cancers, a phenotype that is associated with cancer cell proliferation, progression and angiogenesis. Mouse models of mammary neoplasia have con...
- Characterization of a subpopulation of colon cancer cells with stem cell-like properties
[作者:Chu, P; Clanton, DJ; Snipas, TS; Lee, J; Mitchell, E; Nguyen, ML; Hare, E; Peach, RJ,期刊:International Journal of Cancer, 页码:1312-1321 , 文章类型: Article,,卷期:2009年124-6]
- The biology of the normal colonic mucosa suggests that colon cancer originates from normal colon stem cells. CD44 cancer stem cells have been identified in breast and prostate cancer, and we therefore examined whether CD...
- N-6-isopentenyladenosine inhibits cell proliferation and induces apoptosis in a human colon cancer cell line DLD1
[作者:Laezza, C; Caruso, MG; Gentile, T; Notarnicola, M; Malfitano, AM; Di Matola, T; Messa, C; Gazzerro, P; Bifulco, M,期刊:International Journal of Cancer, 页码:1322-1329 , 文章类型: Article,,卷期:2009年124-6]
- N-6-isopentenyladenosine (i6A) is a modified nucleoside with a pentaatomic isopentenyl derived from mevalonate that induces inhibition of tumor cell proliferation and apoptosis in several tumor cell lines. In this study,...
- Transketolase-like protein 1 (TKTL1) is required for rapid cell growth and full viability of human tumor cells
[作者:Xu, XJ; zur Hausen, A; Coy, JF; Lochelt, M,期刊:International Journal of Cancer, 页码:1330-1337 , 文章类型: Article,,卷期:2009年124-6]
- Cancer cells display high rates of aerobic glycolysis, a phenomenon known as the Warburg effect. Lactate and pyruvate, the end products of glycolysis, are overproduced by cancer cells even in the presence of oxygen. The ...
- Dietary patterns and risk of cancer: A factor analysis in Uruguay
[作者:De Stefani, E; Deneo-Pellegrini, H; Boffetta, P; Ronco, AL; Anne, D; Acosta, G; Mendilaharsu, M; Brennan, P; Ferro, G,期刊:International Journal of Cancer, 页码:1391-1397 , 文章类型: Article,,卷期:2009年124-6]
- A multisite case-control study on factor analysis and several cancer sites (mouth and pharynx, esophagus, stomach, colon, rectum, larynx, lung, breast, prostate, bladder, kidney) was conducted in Uruguay. The study inclu...
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