- Genetic ablation of Rest leads to in vitro-specific derepression of neuronal genes during neurogenesis
[作者:Aoki, H; Hara, A; Era, T; Kunisada, T; Yamada, Y,期刊:Development, 页码:667-677 , 文章类型: Article,,卷期:2012年139-4]
- Rest (RE1-silencing transcription factor, also called Nrsf) is involved in the maintenance of the undifferentiated state of neuronal stem/progenitor cells in vitro by preventing precocious expression of neuronal genes. H...
- Control of neuronal cell fate and number by integration of distinct daughter cell proliferation modes with temporal progression
[作者:Ulvklo, C; MacDonald, R; Bivik, C; Baumgardt, M; Karlsson, D; Thor, S,期刊:Development, 页码:678-689 , 文章类型: Article,,卷期:2012年139-4]
- During neural lineage progression, differences in daughter cell proliferation can generate different lineage topologies. This is apparent in the Drosophila neuroblast 5-6 lineage (NB5-6T), which undergoes a daughter cell...
- Bmp signaling regulates a dose-dependent transcriptional program to control facial skeletal development
[作者:Bonilla-Claudio, M; Wang, J; Bai, Y; Klysik, E; Selever, J; Martin, JF,期刊:Development, 页码:709-719 , 文章类型: Article,,卷期:2012年139-4]
- We performed an in depth analysis of Bmp4, a critical regulator of development, disease, and evolution, in cranial neural crest (CNC). Conditional Bmp4 overexpression, using a tetracycline-regulated Bmp4 gain-of-function...
- Novel Tfap2-mediated control of soxE expression facilitated the evolutionary emergence of the neural crest
[作者:Van Otterloo, E; Li, W; Garnett, A; Cattell, M; Medeiros, DM; Cornell, RA,期刊:Development, 页码:720-730 , 文章类型: Article,,卷期:2012年139-4]
- Gene duplication has been proposed to drive the evolution of novel morphologies. After gene duplication, it is unclear whether changes in the resulting paralogs' coding-regions, or in their cis-regulatory elements, contr...
- Jmjd5, an H3K36me2 histone demethylase, modulates embryonic cell proliferation through the regulation of Cdkn1a expression
[作者:Ishimura, A; Minehata, K; Terashima, M; Kondoh, G; Hara, T; Suzuki, T,期刊:Development, 页码:749-759 , 文章类型: Article,,卷期:2012年139-4]
- Covalent modifications of histones play an important role in chromatin architecture and dynamics. In particular, histone lysine methylation is important for transcriptional control during diverse biological processes. Th...
- A putative tyrosine phosphorylation site of the cell surface receptor Golden goal is involved in synaptic layer selection in the visual system
[作者:Mann, K; Wang, MZ; Luu, SH; Ohler, S; Hakeda-Suzuki, S; Suzuki, T,期刊:Development, 页码:760-771 , 文章类型: Article,,卷期:2012年139-4]
- Golden goal (Gogo) is a cell surface protein that is crucial for proper synaptic layer targeting of photoreceptors (R cells) in the Drosophila visual system. In collaboration with the seven-transmembrane cadherin Flaming...
- Delta Np63 knockout mice reveal its indispensable role as a master regulator of epithelial development and differentiation
[作者:Romano, RA; Smalley, K; Magraw, C; Serna, VA; Kurita, T; Raghavan, S; Sinha, S,期刊:Development, 页码:772-782 , 文章类型: Article,,卷期:2012年139-4]
- The transcription factor p63 is important in the development of the skin as p63-null mice exhibit striking defects in embryonic epidermal morphogenesis. Understanding the mechanisms that underlie this phenotype is compli...
- The lineage-specific gene ponzr1 is essential for zebrafish pronephric and pharyngeal arch development
[作者:Bedell, VM; Person, AD; Larson, JD; McLoon, A; Balciunas, D; Clark, KJ; Neff, KI; Nelson, KE; Bill, BR; Schimmenti, LA; Beiraghi, S; Ekker, SC,期刊:Development, 页码:793-804 , 文章类型: Article,,卷期:2012年139-4]
- The Homeobox (Hox) and Paired box (Pax) gene families are key determinants of animal body plans and organ structure. In particular, they function within regulatory networks that control organogenesis. How these conserved...
- In the absence of BYPASS1-related gene function, the bps signal disrupts embryogenesis by an auxin-independent mechanism
[作者:Lee, DK; Van Norman, JM; Murphy, C; Adhikari, E; Reed, JW; Sieburth, LE,期刊:Development, 页码:805-815 , 文章类型: Article,,卷期:2012年139-4]
- Development is often coordinated by biologically active mobile compounds that move between cells or organs. Arabidopsis mutants with defects in the BYPASS1 (BPS1) gene overproduce an active mobile compound that moves fro...
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