- Erythropoietin receptor contributes to melanoma cell survival in vivo
[作者:Kumar, SM; Zhang, G; Bastian, BC; Arcasoy, MO; Karande, P; Pushparajan, A; Acs, G; Xu, X,期刊:Oncogene, 页码:1649-1660 , 文章类型: Article,,卷期:2012年31-13]
- Erythropoietin (Epo) is widely used clinically to treat anemia associated with various clinical conditions including cancer. Data from several clinical trials suggest significant adverse effect of Epo treatment on cancer...
- CAPC negatively regulates NF-kappa B activation and suppresses tumor growth and metastasis
[作者:Liu, XF; Xiang, L; Zhang, Y; Becker, KG; Bera, TK; Pastan, I,期刊:Oncogene, 页码:1673-1682 , 文章类型: Article,,卷期:2012年31-13]
- CAPC, also known as LRRC26, is expressed in normal prostate and salivary gland. We developed a mAb to CAPC and used it to characterize the protein and study its function. CAPC protein was detected in normal prostate and ...
- Acceleration of clear cell renal cell carcinoma growth in mice following bevacizumab/Avastin treatment: the role of CXCL cytokines
[作者:Grepin, R; Guyot, M; Jacquin, M; Durivault, J; Chamorey, E; Sudaka, A; Serdjebi, C; Lacarelle, B; Scoazec, JY; Negrier, S; Simonnet, H; Pages, G,期刊:Oncogene, 页码:1683-1694 , 文章类型: Article,,卷期:2012年31-13]
- The anti-VEGF targeted antibody bevacizumab (BVZ) has been approved for treating renal cell carcinomas (RCCs). Although BVZ increases the progression-free survival of patients with metastatic RCC, the effect on overall s...
- Genome-wide mapping of Myc binding and gene regulation in serum-stimulated fibroblasts
[作者:Perna, D; Faga, G; Verrecchia, A; Gorski, MM; Barozzi, I; Narang, V; Khng, J; Lim, KC; Sung, WK; Sanges, R; Stupka, E; Oskarsson, T; Trumpp, A; Wei, CL; Muller, H; Amati, B,期刊:Oncogene, 页码:1695-1709 , 文章类型: Article,,卷期:2012年31-13]
- The transition from quiescence to proliferation is a key regulatory step that can be induced by serum stimulation in cultured fibroblasts. The transcription factor Myc is directly induced by serum mitogens and drives a s...
- Insulin-like growth factor-binding protein-1 (IGFBP-1) regulates human schwannoma proliferation, adhesion and survival
[作者:Ammoun, S; Schmid, MC; Zhou, L; Ristic, N; Ercolano, E; Hilton, DA; Perks, CM; Hanemann, CO,期刊:Oncogene, 页码:1710-1722 , 文章类型: Article,,卷期:2012年31-13]
- Merlin is a tumour suppressor involved in the development of a variety of tumours including mesotheliomas. Neurofibromatosis type 2 (NF2), a dominantly inherited tumour disease, is also caused by loss of merlin. NF2 pati...
- Pancreatic beta-cells activate a JunB/ATF3-dependent survival pathway during inflammation
[作者:Gurzov, EN; Barthson, J; Marhfour, I; Ortis, F; Naamane, N; Igoillo-Esteve, M; Gysemans, C; Mathieu, C; Kitajima, S; Marchetti, P; Orntoft, TF; Bakiri, L; Wagner, EF; Eizirik, DL,期刊:Oncogene, 页码:1723-1732 , 文章类型: Article,,卷期:2012年31-13]
- Destruction of insulin-producing pancreatic beta-cells by local autoimmune inflammation is a hallmark of type 1 diabetes. Histochemical analysis of pancreases from non-obese diabetic mice indicated activation of the tran...
- Targeting activation-induced cytidine deaminase prevents colon cancer development despite persistent colonic inflammation
[作者:Takai, A; Marusawa, H; Minaki, Y; Watanabe, T; Nakase, H; Kinoshita, K; Tsujimoto, G; Chiba, T,期刊:Oncogene, 页码:1733-1742 , 文章类型: Article,,卷期:2012年31-13]
- Inflammatory bowel disease (IBD) is an important etiologic factor in the development of colorectal cancer. However, the mechanism underlying carcinogenesis through chronic inflammation is still unknown. Activation-induce...
- MicroRNA-mediated upregulation of integrin-linked kinase promotes Src-induced tumor progression
[作者:Oneyama, C; Morii, E; Okuzaki, D; Takahashi, Y; Ikeda, J; Wakabayashi, N; Akamatsu, H; Tsujimoto, M; Nishida, T; Aozasa, K; Okada, M,期刊:Oncogene, 页码:1623-1635 , 文章类型: Article,,卷期:2012年31-13]
- The tyrosine kinase c-Src is upregulated in various human cancers; however, the molecular mechanisms underlying c-Src-mediated tumor progression remain unclear. Here we show that downregulation of microRNA (miR)-542-3p i...
- A role for caveolin-1 in desmoglein binding and desmosome dynamics
[作者:Brennan, D; Peltonen, S; Dowling, A; Medhat, W; Green, KJ; Wahl, JK; Del Galdo, F; Mahoney, MG,期刊:Oncogene, 页码:1636-1648 , 文章类型: Article,,卷期:2012年31-13]
- Desmoglein-2 (Dsg2) is a desmosomal cadherin that is aberrantly expressed in human skin carcinomas. In addition to its well-known role in mediating intercellular desmosomal adhesion, Dsg2 regulates mitogenic signaling th...
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