- Gab2 regulates the migratory behaviors and E-cadherin expression via activation of the PI3K pathway in ovarian cancer cells
[作者:Wang, Y; Sheng, Q; Spillman, MA; Behbakht, K; Gu, H,期刊:Oncogene, 页码:2512-2520 , 文章类型: Article,,卷期:2012年31-20]
- Ovarian cancer, the most deadly gynecologic malignancy, is often diagnosed late and at the advanced stage when the cancer cells have already migrated and invaded into other tissues and organs. Better understanding of the...
- Tissue transglutaminase links TGF-beta, epithelial to mesenchymal transition and a stem cell phenotype in ovarian cancer
[作者:Cao, L; Shao, M; Schilder, J; Guise, T; Mohammad, KS; Matei, D,期刊:Oncogene, 页码:2521-2534 , 文章类型: Article,,卷期:2012年31-20]
- Tissue transglutaminase (TG2), an enzyme involved in cell proliferation, differentiation and apoptosis is over-expressed in ovarian carcinomas, where it modulates epithelial-to-mesenchymal transition (EMT) and promotes m...
- F-box protein FBXL2 exerts human lung tumor suppressor-like activity by ubiquitin-mediated degradation of cyclin D3 resulting in cell cycle arrest
[作者:Chen, BB; Glasser, JR; Coon, TA; Mallampalli, RK,期刊:Oncogene, 页码:2566-2579 , 文章类型: Article,,卷期:2012年31-20]
- Dysregulated behavior of cell cycle proteins and their control by ubiquitin E3 ligases is an emerging theme in human lung cancer. Here, we identified and characterized the activity of a novel F-box protein, termed FBXL2,...
- NF-kappa B inducing kinase (NIK) modulates melanoma tumorigenesis by regulating expression of pro-survival factors through the beta-catenin pathway
[作者:Thu, YM; Su, Y; Yang, J; Splittgerber, R; Na, S; Boyd, A; Mosse, C; Simons, C; Richmond, A,期刊:Oncogene, 页码:2580-2592 , 文章类型: Article,,卷期:2012年31-20]
- Nuclear factor-kappa B (NF-kappa B) inducing kinase (NIK) is a MAP3K that regulates the activation of NF-kappa B. NIK is often highly expressed in tumor cells, including melanoma, but the significance of this in melanoma...
- Proteins kinase C epsilon is required for non-small cell lung carcinoma growth and regulates the expression of apoptotic genes
[作者:Caino, MC; Lopez-Haber, C; Kim, J; Mochly-Rosen, D; Kazanietz, MG,期刊:Oncogene, 页码:2593-2600 , 文章类型: Article,,卷期:2012年31-20]
- Protein kinase C (PKC)epsilon, a member of the novel PKC family, has key roles in mitogenesis and survival in normal and cancer cells. PKC epsilon is frequently overexpressed in epithelial cancers, particularly in lung c...
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