Familial lipoprotein lipase (LPL) deficiency is an inherited condition involving autosomal recessive mutations in the LPL gene, which provides an enzyme responsible for the breakdown of lipoproteins to release fats th...
Debio-025 (UNIL-025) is a first-in-class nonimmunosuppressive cyclophilin inhibitor that has demonstrated in vitro antiviral activity against hepatitis C virus (HCV) and HIV-1 superior to ciclosporin. Antiviral activi...
The tuberculosis (TB) epidemic constitutes a major global health threat. The steady emergence of Mycobacterium tuberculosis strains resistant to current anti-TB drugs, the therapeutic obstacles posited by coinfection ...
Oxidative injury has been implicated in the etiology of a number of neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis (ALS) and Huntington's disease. Antioxida...
Plasmodium falciparum, the most virulent human malaria parasite, has an extended course of sexual development that is required for transmission of the disease. The 48-h asexual cycle is responsible for the clinical sy...
Hypertension is a pathophysiological state of persistently high blood pressure and is a major risk factor for stroke, coronary heart disease, heart failure, renal failure and arterial aneurysm. Despite recent success ...
Although mucormycosis is not as frequent as candidiasis and aspergillosis, it remains a challenge for clinicians and microbiologists. Mucormycosis is a rare infection, although some institutions report an increasing i...
Galectins are a 15-member family of beta-lactoside-specific lectins. They are expressed differentially in normal versus neoplastic tissues and are known to play important roles in biological processes pertinent to cel...
The 6th World Stroke Congress was organized by the World Stroke Organization (WSO) and took place in Vienna on September 24-27, 2008. The biennial meeting was attended by approximately 3,000 medical doctors, scientist...
The latest global figures from the World Health Organization (WHO) from 2005 indicate that approximately 1.6 billion adults are overweight and at least 400 million are obese, i.e., have a body mass index (BMI = weight...