A new NHC.Pd-catalyzed asymmetric alpha-arylation of amides is reported that gives direct access to synthetically valuable, allylated oxindoles with quaternary carbon centers. The reaction is made possible by the introdu...
Metal complexes of picolinaldehyde are identified as low-cost and environmentally benign catalysts, providing high reaction rates and turnovers for the racemization of amino acids. These pyridoxal surrogates demonstrate ...
A small network of synthetic replicators is capable of responding to instructional inputs such that the output of the network is an excess of one of the replicators whenever the input contains either or both of the repli...
Oximes and alpha-ketoacids undergo an unexpectedly facile and chemoselective annulation to afford 2,5-dihydrooxazole 3-oxides. The resulting cyclic nitrones serve as chemically and configurationally stable masked a-ketoa...
A series of axially chiral bis-sulfoxide ligands have been efficiently synthesized via oxidative coupling with high diastereoselectivities. The axial chirality is well controlled by the tert-butylsulfinyl or the p-tolyls...
Azole derivatives were synthesized by iron-catalyzed. Oxidative reactions of azoles and ethers in good to excellent yields. A wide variety of azoles and ethers were selectively transformed into the corresponding oxidativ...
A new fluorescent assay for Ser/Thr protein phosphatases has been developed. Hydrolysis of a phosphoSer residue liberates the Ser hydroxyl group, which induces a cyclization reaction on the N-terminal carbamate and relea...
An intramolecular exciplex is formed upon excitation of the cyclohexane solution of the 1,4-dicyano-2-methylnaphthalene-N,N-dimethyl-p-toluidine dyad, but little if any intramolecular CT complex exists in the ground stat...
Straightforward access toward previously unreported substituted, heterocyclic spiro[3.3]heptanes is disclosed. These spirocyclic systems may be considered as alternatives to 1,3-heteroatom-substituted cyclohexanes, which...
It was found that beta-ketoesters were directly transformed to the corresponding alpha-hydroxymalonic esters, tartronic esters, with molecular oxygen catalyzed by calcium iodide under visible light irradiation from fluor...
The synthesis of several highly functionalized 2,3-dihydroselenophenes from homopropargyl selenides via electrophilic cyclization is described. Electrophiles such as 12, ICI, and PhSeBr were used in a simple process empl...
The sequential transformation of arynes into ortho-disubstituted arenes is achieved by a one-pot procedure using formamides and dialkylzincs. This reaction proceeded via A route involving the trapping reaction of the for...
Dihydropyran derivatives readily undergo addition to N-acyl imines in the presence of chiral phosphoric acids. This addition process yields an attractive product that is capable of a tandem oxidative-cyclization via an e...
A general and efficient procedure for the preparation of phenols was developed by copper-catalyzed oxidative hydroxylation of arylboronic acids at room temperature in water.
syn-Tertiary homoallylic alcohols were obtained by: the reaction of alpha-silylallenyltitanocenes generated by the reductive titanation of gamma-silylpropargylic carbonates with Cp2Ti[P(OEt)(3)](2) with ketones and follo...
Pd-II-catalyzed Fujiwara-Moritani reactions can be carried out without external acid at room temperature and in water as the only medium. A highly active cationic Pd-II catalyst, [Pd(MeCN)(4)](BF4)(2) easily activates ar...