- Valganciclovir Reduces T Cell Activation in HIV-infected Individuals With Incomplete CD4(+) T Cell Recovery on Antiretroviral Therapy
[作者:Hunt, PW; Martin, JN; Sinclair, E; Epling, L; Teague, J; Jacobson, MA; Tracy, RP; Corey, L; Deeks, SG,期刊:Journal of Infectious Diseases, 页码:1474-1483 , 文章类型: Article,,卷期:2011年203-10]
- Methods. Thirty antiretroviral therapy-treated HIV-infected CMV-seropositive participants with CD4 counts < 350 cells/mm(3) were randomized to receive valganciclovir 900 mg daily or placebo for 8 weeks, followed by an ad...
- Single and Multiple Dose Pharmacokinetics of Maraviroc in Saliva, Semen, and Rectal Tissue of Healthy HIV-negative Men
[作者:Brown, KC; Patterson, KB; Malone, SA; Shaheen, NJ; Prince, HMA; Dumond, JB; Spacek, MB; Heidt, PE; Cohen, MS; Kashuba, ADM,期刊:Journal of Infectious Diseases, 页码:1484-1490 , 文章类型: Article,,卷期:2011年203-10]
- Methods. A pharmacokinetic study was performed in 12 HIV-negative men receiving maraviroc 300 mg twice daily for 8 days. Seven time-matched pairs of blood plasma (BP) and saliva samples were collected over 12 h on day 1 ...
- Genome-wide Association Study Implicates PARD3B-based AIDS Restriction
[作者:Troyer, JL; Nelson, GW; Lautenberger, JA; Chinn, L; McIntosh, C; Johnson, RC; Sezgin, E; Kessing, B; Malasky, M; Hendrickson, SL; Li, G; Pontius, J; Tang, MZ; An, P; Winkler, CA; Limou, S; Le Clerc, S; Delaneau, O; Zagury, JF; Schuitemaker, H; van Manen, D; Bream, JH; Gomperts, ED; Buchbinder, S; Goedert, JJ; Kirk, GD; O'Brien, SJ,期刊:Journal of Infectious Diseases, 页码:1491-1502 , 文章类型: Article,,卷期:2011年203-10]
- Methods. European American HIV seroconverters (n = 755) were interrogated for single-nucleotide polymorphisms (SNPs) (n = 700,022) associated with progression to AIDS 1987 (Cox proportional hazards regression analysis, c...
- Murine model of Clostridium difficile infection (CDI) using aged gnotobiotic C57BL/6 mice and a BI strain (vol 202, pg 1708, 2010)
[作者:Pawlowski, SW; Calabrese, G; Kolling, GL; Platts-Mills, J; Freire, R; Warren, CA; Liu, B; Sartor, RB; Guerrant, RL,期刊:Journal of Infectious Diseases, 页码:1505-1505 , 文章类型: Correction,,卷期:2011年203-10]
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- Shifting Genetic Structure of Invasive Serotype 19A Pneumococci in the United States
[作者:Beall, BW; Gertz, RE; Hulkower, RL; Whitney, CG; Moore, MR; Brueggemann, AB,期刊:Journal of Infectious Diseases, 页码:1360-1368 , 文章类型: Article,,卷期:2011年203-10]
- Background. Following 7-valent conjugate vaccine introduction in the United States in 2000, invasive serotype (sero19A) pneumococcal disease (IPD) emerged rapidly. Sero19A IPD incidence increased slightly during 2005-200...
- Type II Secretion System of Pseudomonas aeruginosa: In Vivo Evidence of a Significant Role in Death Due to Lung Infection
[作者:Jyot, J; Balloy, V; Jouvion, G; Verma, A; Touqui, L; Huerre, M; Chignard, M; Ramphal, R,期刊:Journal of Infectious Diseases, 页码:1369-1377 , 文章类型: Article,,卷期:2011年203-10]
- Methods. Using a model of pneumonia in Toll-like receptor (TLR) 2,4(-/-) mice, we reexamined the role of the T2SS system. Flagellin-deficient mutants of P. aeruginosa, with mutations in the T2SS and/or T3SS, were used to...
- High Frequency, Sustained T Cell Responses to PARV4 Suggest Viral Persistence In Vivo
[作者:Simmons, R; Sharp, C; Sims, S; Kloverpris, H; Goulder, P; Simmonds, P; Bowness, P; Klenerman, P,期刊:Journal of Infectious Diseases, 页码:1378-1387 , 文章类型: Article,,卷期:2011年203-10]
- Methods. Interferon gamma (IFN-gamma) enzyme-linked immunospot assay, intracellular cytokine staining, and a tetrameric HLA-A*0201-peptide complex were used to define the lymphocyte populations responding to PARV4 NS pep...
- Pneumonia in Military Trainees: A Comparison Study Based on Adenovirus Serotype 14 Infection
[作者:Vento, TJ; Prakash, V; Murray, CK; Brosch, LC; Tchandja, JB; Cogburn, C; Yun, HC,期刊:Journal of Infectious Diseases, 页码:1388-1395 , 文章类型: Article,,卷期:2011年203-10]
- Methods. Medical records of military trainees hospitalized with pneumonia during an outbreak of Ad-14 infection were reviewed. Clinical, radiographic, and laboratory parameters were compared on the basis of Ad-14 infecti...
- A West Nile Virus DNA Vaccine Utilizing a Modified Promoter Induces Neutralizing Antibody in Younger and Older Healthy Adults in a Phase I Clinical Trial
[作者:Ledgerwood, JE; Pierson, TC; Hubka, SA; Desai, N; Rucker, S; Gordon, IJ; Enama, ME; Nelson, S; Nason, M; Gu, WJ; Bundrant, N; Koup, RA; Bailer, RT; Mascola, JR; Nabel, GJ; Graham, BS,期刊:Journal of Infectious Diseases, 页码:1396-1404 , 文章类型: Article,,卷期:2011年203-10]
- Methods. A DNA vaccine encoding the protein premembrane and the E glycoproteins of the NY99 strain of WNV under the transcriptional control of the CMV/R promoter was evaluated in an open-label study in 30 healthy adults....
- Detection of Higher Levels of Dengue Viremia Using Fc gamma R-expressing BHK-21 Cells Than Fc gamma R-negative Cells in Secondary Infection but Not in Primary Infection
[作者:Moi, ML; Lim, CK; Kotaki, A; Takasaki, T; Kurane, I,期刊:Journal of Infectious Diseases, 页码:1405-1414 , 文章类型: Article,,卷期:2011年203-10]
- It has been reported that levels of viremia reflect the severity of illness in dengue virus infection. We assessed the levels of viremia in patients with primary and secondary infections, using 2 cell lines: Fc gamma R-e...
- Impaired Interferon Signaling in Dendritic Cells From Older Donors Infected In Vitro With West Nile Virus
[作者:Qian, F; Wang, XM; Zhang, L; Lin, AP; Zhao, HY; Fikrig, E; Montgomery, RR,期刊:Journal of Infectious Diseases, 页码:1415-1424 , 文章类型: Article,,卷期:2011年203-10]
- West Nile virus (WNV), a mosquito-borne, single-stranded RNA flavivirus, causes significant human morbidity and mortality in the older population; thus, we investigated the effects of aging on infection with WNV in dendr...
- Viral Load in the Natural History of Human Papillomavirus Type 16 Infection: A Nested Case-control Study
[作者:Xi, LF; Hughes, JP; Castle, PE; Edelstein, ZR; Wang, CH; Galloway, DA; Koutsky, LA; Kiviat, NB; Schiffman, M,期刊:Journal of Infectious Diseases, 页码:1425-1433 , 文章类型: Article,,卷期:2011年203-10]
- Methods. This case-control study was nested within the 2-year Atypical Squamous Cells of Undetermined Significance and Low-Grade Squamous Intraepithelial Lesion Triage Study, in which women were followed semiannually for...
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