- Phase 3 randomized, placebo-controlled, double-blind study of high-dose continuous infusion cytarabine alone or with laromustine (VNP40101M) in patients with acute myeloid leukemia in first relapse
[作者：Giles, F; Vey, N; DeAngelo, D; Seiter, K; Stock, W; Stuart, R; Boskovic, D; Pigneux, A; Tallman, M; Brandwein, J; Kell, J; Robak, T; Staib, P; Thomas, X; Cahill, A; Albitar, M; O'Brien, S,期刊：Blood, 页码：4027-4033 , 文章类型： Article，,卷期：2009年114-19]
- Laromustine is a sulfonylhdrazine alkylator with significant antileukemia activity. An international, randomized (2: 1), double-blind, placebo-controlled study was conducted to compare complete remission (CR) rates and o...
- CD4(+)FOXP3(+) regulatory T cells confer long-term regulation of factor VIII-specific immune responses in plasmid-mediated gene therapy-treated hemophilia mice
[作者：Miao, CH; Harmeling, BR; Ziegler, SF; Yen, BC; Torgerson, T; Chen, LP; Yau, RJ; Peng, BW; Thompson, AR; Ochs, HD; Rawlings, DJ,期刊：Blood, 页码：4034-4044 , 文章类型： Article，,卷期：2009年114-19]
- Gene transfer of a factor VIII (FVIII) plasmid into hemophilia A (HemA) mice achieved supraphysiologic FVIII expression, but triggered production of high-titer FVIII-specific antibodies and loss of functional FVIII activ...
- Erythroid dysplasia, megaloblastic anemia, and impaired lymphopoiesis arising from mitochondrial dysfunction
[作者：Chen, ML; Logan, TD; Hochberg, ML; Shelat, SG; Yu, X; Wilding, GE; Tan, W; Kujoth, GC; Prolla, TA; Selak, MA; Kundu, M; Carroll, M; Thompson, JE,期刊：Blood, 页码：4045-4053 , 文章类型： Article，,卷期：2009年114-19]
- Recent reports describe hematopoietic abnormalities in mice with targeted instability of the mitochondrial genome. However, these abnormalities have not been fully described. We demonstrate that mutant animals develop an...
- In vivo prostaglandin E-2 treatment alters the bone marrow microenvironment and preferentially expands short-term hematopoietic stem cells
[作者：Frisch, BJ; Porter, RL; Gigliotti, BJ; Olm-Shipman, AJ; Weber, JM; O'Keefe, RJ; Jordan, CT; Calvi, LM,期刊：Blood, 页码：4054-4063 , 文章类型： Article，,卷期：2009年114-19]
- Microenvironmental signals can determine hematopoietic stem cell (HSC) fate choices both directly and through stimulation of niche cells. In the bone marrow, prostaglandin E-2 (PGE(2)) is known to affect both osteoblasts...
- Dysfunctional expansion of hematopoietic stem cells and block of myeloid differentiation in lethal sepsis
[作者：Rodriguez, S; Chora, A; Goumnerov, B; Mumaw, C; Goebel, WS; Fernandez, L; Baydoun, H; HogenEsch, H; Dombkowski, DM; Karlewicz, CA; Rice, S; Rahme, LG; Carlesso, N,期刊：Blood, 页码：4064-4076 , 文章类型： Article，,卷期：2009年114-19]
- Severe sepsis is one of the leading causes of death worldwide. High mortality rates in sepsis are frequently associated with neutropenia. Despite the central role of neutrophils in innate immunity, the mechanisms causing...
- Spatial gradients of blood vessels and hematopoietic stem and progenitor cells within the marrow cavities of the human skeleton
[作者：Bourke, VA; Watchman, CJ; Reith, JD; Jorgensen, ML; Dieudonne, A; Bolch, WE,期刊：Blood, 页码：4077-4080 , 文章类型： Article，,卷期：2009年114-19]
- This report evaluates the spatial profile of blood vessel fragments (BVFs) and CD34(+) and CD117(+) hematopoietic stem and progenitor cells (HSPCs) in human cancellous bone. Bone specimens were sectioned, immunostained (...
- Fibronectin maintains survival of mouse natural killer (NK) cells via CD11b/Src/beta-catenin pathway
[作者：Zhang, T; Liu, SX; Yang, PY; Han, CF; Wang, JL; Liu, J; Han, YM; Yu, YZ; Cao, XT,期刊：Blood, 页码：4081-4088 , 文章类型： Article，,卷期：2009年114-19]
- Tissue microenvironment and stroma-derived extracellular matrix (ECM) molecules play important roles in the survival and differentiation of cells. Mouse natural killer (NK) cells usually die within 24 hours once isolated...
- Interleukin-21 restores immunoglobulin production ex vivo in patients with common variable immunodeficiency and selective IgA deficiency
[作者：Borte, S; Pan-Hammarstrom, Q; Liu, CH; Sack, U; Borte, M; Wagner, U; Graf, D; Hammarstrom, L,期刊：Blood, 页码：4089-4098 , 文章类型： Article，,卷期：2009年114-19]
- Interleukin-21 (IL-21) is an important promoter for differentiation of human B cells into immunoglobulin (Ig)-secreting cells. The objective of this study was to evaluate an IL-21-based approach to induce immunoglobulin ...
- Comprehensive assessment of T-cell receptor beta-chain diversity in alpha beta T cells
[作者：Robins, HS; Campregher, PV; Srivastava, SK; Wacher, A; Turtle, CJ; Kahsai, O; Riddell, SR; Warren, EH; Carlson, CS,期刊：Blood, 页码：4099-4107 , 文章类型： Article，,卷期：2009年114-19]
- The adaptive immune system uses several strategies to generate a repertoire of T- and B-cell antigen receptors with sufficient diversity to recognize the universe of potential pathogens. In alpha beta T cells, which prim...
- Uptake of CCR7 and acquisition of migratory properties by human KIR+ NK cells interacting with monocyte-derived DC or EBV cell lines: regulation by KIR/HLA-class I interaction
[作者：Marcenaro, E; Cantoni, C; Pesce, S; Prato, C; Pende, D; Agaugue, S; Moretta, L; Moretta, A,期刊：Blood, 页码：4108-4116 , 文章类型： Article，,卷期：2009年114-19]
- C-C chemokine receptor type 7 (CCR7) is a chemokine receptor playing a pivotal role in the induction of human natural killer (NK)-cell migration to lymph nodes. We show that "licensed" peripheral blood killer immunoglobu...
- Different NK cell-activating receptors preferentially recruit Rab27a or Munc13-4 to perforin-containing granules for cytotoxicity
[作者：Wood, SM; Meeths, M; Chiang, SCC; Bechensteen, AG; Boelens, JJ; Heilmann, C; Horiuchi, H; Rosthoj, S; Rutynowska, O; Winiarski, J; Stow, JL; Nordenskjold, M; Henter, JI; Ljunggren, HG; Bryceson, YT,期刊：Blood, 页码：4117-4127 , 文章类型： Article，,卷期：2009年114-19]
- The autosomal recessive immunodeficiencies Griscelli syndrome type 2 (GS2) and familial hemophagocytic lymphohistiocytosis type 3 (FHL3) are associated with loss-of-function mutations in RAB27A (encoding Rab27a) and UNC1...
- The role of the human cytomegalovirus UL111A gene in down-regulating CD4(+) T-cell recognition of latently infected cells: implications for virus elimination during latency
[作者：Cheung, AKL; Gottlieb, DJ; Plachter, B; Pepperl-Klindworth, S; Avdic, S; Cunningham, AL; Abendroth, A; Slobedman, B,期刊：Blood, 页码：4128-4137 , 文章类型： Article，,卷期：2009年114-19]
- The capacity of human cytomegalovirus ( HCMV) to establish and maintain a latent infection from which it can later reactivate ensures its widespread distribution in the population, but the mechanisms enabling maintenance...
- Wild-type FOXP3 is selectively active in CD4(+)CD25(hi) regulatory T cells of healthy female carriers of different FOXP3 mutations
[作者：Di Nunzio, S; Cecconi, M; Passerini, L; McMurchy, AN; Baron, U; Turbachova, I; Vignola, S; Valencic, E; Tommasini, A; Junker, A; Cazzola, G; Olek, S; Levings, MK; Perroni, L; Roncarolo, MG; Bacchetta, R,期刊：Blood, 页码：4138-4141 , 文章类型： Article，,卷期：2009年114-19]
- Forkhead box P3 (FOXP3) is constitutively expressed by CD4(+)CD25(hi) regulatory T cells (nTregs). Mutations of FOXP3 cause a severe autoimmune syndrome known as immune dysregulation polyendocrinopathy enteropathy X-link...
- Vaccine site inflammation potentiates idiotype DNA vaccine-induced therapeutic T cell-, and not B cell-, dependent antilymphoma immunity
[作者：Qin, H; Cha, SC; Neelapu, SS; Lou, YY; Wei, JS; Liu, YJ; Kwak, LW,期刊：Blood, 页码：4142-4149 , 文章类型： Article，,卷期：2009年114-19]
- Lymphoma idiotype protein vaccines have shown therapeutic potential in previous clinical studies, and results from a completed pivotal, phase 3 controlled trial are promising. However, streamlined production of these pat...
- Pim kinase inhibitor, SGI-1776, induces apoptosis in chronic lymphocytic leukemia cells
[作者：Chen, LS; Redkar, S; Bearss, D; Wierda, WG; Gandhi, V,期刊：Blood, 页码：4150-4157 , 文章类型： Article，,卷期：2009年114-19]
- Pim kinases are involved in B-cell development and are overexpressed in B-cell chronic lymphocytic leukemia (CLL). We hypothesized that Pim kinase inhibition would affect B-cell survival. Identified from a screen of imid...
- E mu-BCL10 mice exhibit constitutive activation of both canonical and noncanonical NF-kappa B pathways generating marginal zone (MZ) B-cell expansion as a precursor to splenic MZ lymphoma
[作者：Li, ZY; Wang, HS; Xue, LQ; Shin, DM; Roopenian, D; Xu, W; Qi, CF; Sangster, MY; Orihuela, CJ; Tuomanen, E; Rehg, JE; Cui, XL; Zhang, QG; Morse, HC; Morris, SW,期刊：Blood, 页码：4158-4168 , 文章类型： Article，,卷期：2009年114-19]
- BCL10, required for nuclear factor kappa B (NF-kappa B) activation during antigen-driven lymphocyte responses, is aberrantly expressed in mucosa-associated lymphoid tissue-type marginal zone (MZ) lymphomas because of chr...
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