- CD56(+) human blood dendritic cells effectively promote T(H)1-type gamma delta T-cell responses
[作者：Gruenbacher, G; Gander, H; Rahm, A; Nussbaumer, W; Romani, N; Thurnher, M,期刊：Blood, 页码：4422-4431 , 文章类型： Article，,卷期：2009年114-20]
- CD56(+) human dendritic cells (DCs) have recently been shown to differentiate from monocytes in response to GM-CSF and type 1 interferon in vitro. We show here that CD56(+) cells freshly isolated from human peripheral bl...
- The thymus-independent immunity conferred by a pneumococcal polysaccharide is mediated by long-lived plasma cells
[作者：Taillardet, M; Haffar, G; Mondiere, P; Asensio, MJ; Gheit, H; Burdin, N; Defrance, T; Genestier, L,期刊：Blood, 页码：4432-4440 , 文章类型： Article，,卷期：2009年114-20]
- It was recently shown that bacterial thymus-independent (TI) antigens confer long-lasting immunity and generate memory B lymphocytes. However, reactivation of TI memory B cells is repressed in immunocompetent mice, thus ...
- Diverse marrow stromal cells protect CLL cells from spontaneous and drug-induced apoptosis: development of a reliable and reproducible system to assess stromal cell adhesion-mediated drug resistance
[作者：Kurtova, AV; Balakrishnan, K; Chen, R; Ding, W; Schnabl, S; Quiroga, MP; Sivina, M; Wierda, WG; Estrov, Z; Keating, MJ; Shehata, M; Jager, U; Gandhi, V; Kay, NE; Plunkett, W; Burger, JA,期刊：Blood, 页码：4441-4450 , 文章类型： Article，,卷期：2009年114-20]
- Marrow stromal cells (MSCs) provide important survival and drug resistance signals to chronic lymphocytic leukemia (CLL) cells, but current models to analyze CLL-MSC interactions are heterogeneous. Therefore, we tested d...
- Extensive intraclonal diversification in a subgroup of chronic lymphocytic leukemia patients with stereotyped IGHV4-34 receptors: implications for ongoing interactions with antigen
[作者：Sutton, LA; Kostareli, E; Hadzidimitriou, A; Darzentas, N; Tsaftaris, A; Anagnostopoulos, A; Rosenquist, R; Stamatopoulos, K,期刊：Blood, 页码：4460-4468 , 文章类型： Article，,卷期：2009年114-20]
- Several studies indicate that the development of chronic lymphocytic leukemia (CLL) may be influenced by antigen recognition through the clonotypic B-cell receptors (BCRs). However, it is still unclear whether antigen in...
- Chronic lymphocytic leukemia of E mu-TCL1 transgenic mice undergoes rapid cell turnover that can be offset by extrinsic CD257 to accelerate disease progression
[作者：Enzler, T; Kater, AP; Zhang, W; Widhopf, GF; Chuang, HY; Lee, J; Avery, E; Croce, CM; Karin, M; Kipps, TJ,期刊：Blood, 页码：4469-4476 , 文章类型： Article，,卷期：2009年114-20]
- Results of heavy-water labeling studies have challenged the notion that chronic lymphocytic leukemia (CLL) represents an accumulation of noncycling B cells. We examined leukemia cell turnover in E mu-TCL1 transgenic (TCL...
- Generation of CD8(+) T cell-mediated immunity against idiotype-negative lymphoma escapees
[作者：Varghese, B; Widman, A; Do, J; Taidi, B; Czerwinski, DK; Timmerman, J; Levy, S; Levy, R,期刊：Blood, 页码：4477-4485 , 文章类型： Article，,卷期：2009年114-20]
- We investigated the ability of CpG-oligodeoxynucleotide to generate an antitumor CD8(+) T-cell immune response and to synergize with passive antibody therapy. For these studies, wegenerated an antibody against the idioty...
- Gene expression-based classification and regulatory networks of pediatric acute lymphoblastic leukemia
[作者：Li, ZG; Zhang, W; Wu, MY; Zhu, SS; Gao, C; Sun, L; Zhang, RD; Qiao, N; Xue, HL; Hu, YM; Bao, SL; Zheng, HY; Han, JDJ,期刊：Blood, 页码：4486-4493 , 文章类型： Article，,卷期：2009年114-20]
- Pediatric acute lymphoblastic leukemia (ALL) contains cytogenetically distinct subtypes that respond differently to cytotoxic drugs. Subtype classification can be also achieved through gene expression profiling. However,...
- A human monoclonal antibody drug and target discovery platform for B-cell chronic lymphocytic leukemia based on allogeneic hematopoietic stem cell transplantation and phage display
[作者：Baskar, S; Suschak, JM; Samija, I; Srinivasan, R; Childs, RW; Pavletic, SZ; Bishop, MR; Rader, C,期刊：Blood, 页码：4494-4502 , 文章类型： Article，,卷期：2009年114-20]
- Allogeneic hematopoietic stem cell transplantation (alloHSCT) is the only potentially curative treatment available for patients with B-cell chronic lymphocytic leukemia (B-CLL). Here, we show that post-alloHSCT antibody ...
- Inactivating SOCS1 mutations are caused by aberrant somatic hypermutation and restricted to a subset of B-cell lymphoma entities
[作者：Mottok, A; Renne, C; Seifert, M; Oppermann, E; Bechstein, W; Hansmann, ML; Kuppers, R; Brauninger, A,期刊：Blood, 页码：4503-4506 , 文章类型： Article，,卷期：2009年114-20]
- STATs are constitutively activated in several malignancies. In primary mediastinal large B-cell lymphoma and Hodgkin lymphoma (HL), inactivating mutations in SOCS1, an inhibitor of JAK/STAT signaling, contribute to dereg...
- The BH3-only protein Bim plays a critical role in leukemia cell death triggered by concomitant inhibition of the PI3K/Akt and MEK/ERK1/2 pathways
[作者：Rahmani, M; Anderson, A; Habibi, JR; Crabtree, TR; Mayo, M; Harada, H; Ferreira-Gonzalez, A; Dent, P; Grant, S,期刊：Blood, 页码：4507-4516 , 文章类型： Article，,卷期：2009年114-20]
- Mechanisms underlying apoptosis induced by concomitant interruption of the mitogen-activated protein kinase kinase/extracellular signal-regulated kinase 1/2 (MEK/ERK1/2) and phosphatidylinositol 3-kinase (PI3K)/Akt pathw...
- GM-CSF and IL-4 induce dendritic cell differentiation and disrupt osteoclastogenesis through M-CSF receptor shedding by up-regulation of TNF-alpha converting enzyme (TACE)
[作者：Hiasa, M; Abe, M; Nakano, A; Oda, A; Amou, H; Kido, S; Takeuchi, K; Kagawa, K; Yata, K; Hashimoto, T; Ozaki, S; Asaoka, K; Tanaka, E; Moriyama, K; Matsumoto, T,期刊：Blood, 页码：4517-4526 , 文章类型： Article，,卷期：2009年114-20]
- Monocytes give rise to macrophages, osteoclasts (OCs), and dendritic cells (DCs). Macrophage colony-stimulating factor (M-CSF) and receptor activator of nuclear factor-kappaB (RANK) ligand induce OC differentiation from ...
- Platelet-associated complement factor H in healthy persons and patients with atypical HUS
[作者：Licht, C; Pluthero, FG; Li, L; Christensen, H; Habbig, S; Hoppe, B; Geary, DF; Zipfel, PF; Kahr, WHA,期刊：Blood, 页码：4538-4545 , 文章类型： Article，,卷期：2009年114-20]
- Atypical hemolytic uremic syndrome (aHUS) is associated with complement system dysregulation, and more than 25% of pediatric aHUS cases are linked to mutations in complement factor H (CFH) or CFH autoantibodies. The obse...
- Platelet CFH: in search of the source
[作者：Akkerman, JWN,期刊：Blood, 页码：4323-4324 , 文章类型： Editorial Material，,卷期：2009年114-20]
- CFH protects platelets against complement attack. In this issue of Blood, Licht and colleagues unexpectedly identify CFH at intracellular localizations other than alpha granules, where CFH had previously been thought to ...
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