- Mutant mouse p53 transgene elevates the chemical induction of tumors that respond to gene silencing with siRNA
[作者:Tanooka, H; Tatsumi, K; Tsuji, H; Noda, Y; Katsube, T; Ishii, H; Ootsuyama, A; Takeshita, F; Ochiya, T,期刊:Cancer gene therapy, 页码:1-10 , 文章类型: Article,,卷期:2010年17-1]
To study the role of mutant p53 in the induction and cure of tumors, we generated transgenic mice carrying mutant p53 (mp53) containing a 9 bp deletion in exon 6 in addition to wild-type p53, expressing both p53 and m...
- Intraperitoneal administration of telomerase-specific oncolytic adenovirus sensitizes ovarian cancer cells to cisplatin and affects survival in a xenograft model with peritoneal dissemination
[作者:Takakura, M; Nakamura, M; Kyo, S; Hashimoto, M; Mori, N; Ikoma, T; Mizumoto, Y; Fujiwara, T; Urata, Y; Inoue, M,期刊:Cancer gene therapy, 页码:11-19 , 文章类型: Article,,卷期:2010年17-1]
- Despite tremendous development in chemotherapy for ovarian cancer over the past few decades, the prognosis of advanced cases with massive peritoneal dissemination is still unsatisfactory, and novel treatment modalities t...
- Oncolytic adenovirus expressing interleukin-18 induces significant antitumor effects against melanoma in mice through inhibition of angiogenesis
[作者:Zheng, JN; Pei, DS; Mao, LJ; Liu, XY; Sun, FH; Zhang, BF; Liu, YQ; Liu, JJ; Li, W; Han, D,期刊:Cancer gene therapy, 页码:28-36 , 文章类型: Article,,卷期:2010年17-1]
- It has been shown that interleukin 18 (IL-18) exerts antitumor activity. In this study, we investigated whether oncolytic adenovirus-mediated gene transfer of IL-18 could induce strong antitumor activity. A tumor-selecti...
- Enhancement of antitumor activity of gammaretrovirus carrying IL-12 gene through genetic modification of envelope targeting HER2 receptor: a promising strategy for bladder cancer therapy
[作者:Tsai, YS; Shiau, AL; Chen, YF; Tsai, HT; Tzai, TS; Wu, CL,期刊:Cancer gene therapy, 页码:37-48 , 文章类型: Article,,卷期:2010年17-1]
- The objective of this study was to develop an HER2-targeted, envelope-modified Moloney murine leukemia virus (MoMLV)-based gammaretroviral vector carrying interleukin (IL)-12 gene for bladder cancer therapy. It displayed...
- Suppression of ovarian cancer growth via systemic administration with liposome-encapsulated adenovirus-encoding endostatin
[作者:Yang, L; Wang, L; Su, XQ; Wang, L; Chen, XC; Li, D; Luo, ST; Shi, HS; Chen, LJ; Wang, YS,期刊:Cancer gene therapy, 页码:49-57 , 文章类型: Article,,卷期:2010年17-1]
- Gene therapy using adenoviral vector containing the endostatin gene is a promising strategy for advanced cancers. However, host immune response to adenovirus and the lack of the requisite coxsackie-adenovirus receptor (C...
- Heat-induced transcription of diphtheria toxin A or its variants, CRM176 and CRM197: implications for pancreatic cancer gene therapy
[作者:Fogar, P; Navaglia, F; Basso, D; Zambon, CF; Moserle, L; Indraccolo, S; Stranges, A; Greco, E; Fadi, E; Padoan, A; Pantano, G; Sanzari, MC; Pedrazzoli, S; Montecucco, C; Plebani, M,期刊:Cancer gene therapy, 页码:58-68 , 文章类型: Article,,卷期:2010年17-1]
- Vectors combining the heat shock proteins (HSPs) promoter with the catalytic subunit A of the diphtheria toxin (DTA) or its variants, cross-reacting material (CRM) 176 and 197, were engineered to investigate the effect o...
|