- HINT1 inhibits beta-catenin/TCF4, USF2 and NF kappa B activity in human hepatoma cells
[作者:Wang, L; Li, HY; Zhang, YJ; Santella, RM; Weinstein, IB,期刊:International Journal of Cancer, 页码:1526-1534 , 文章类型: Article,,卷期:2009年124-7]
- In this study we explored the relevance of Hint, a novel tumor suppressor gene, to human hepatoma. The human hepatoma cell lines Hep3B and HepG2 express very low levels of the HINT1 protein but the Huh7 cells express a r...
- Combined anti-PDGFR alpha and PDGFR beta targeting in non-small cell lung cancer
[作者:Reinmuth, N; Liersch, R; Raedel, M; Fehrmann, F; Fehrmann, N; Bayer, M; Schwoeppe, C; Kessler, T; Berdel, W; Thomas, M; Mesters, RM,期刊:International Journal of Cancer, 页码:1535-1544 , 文章类型: Article,,卷期:2009年124-7]
- Activation of the platelet-derived growth factor (PDGF)-receptors is critically involved into various stromal cell functions including recruitment of stromal cells and vascular endothelial growth factor (VEGF) induction ...
- The gene expression signature of genomic instability in breast cancer is an independent predictor of clinical outcome
[作者:Habermann, JK; Doering, J; Hautaniemi, S; Roblick, UJ; Bundgen, NK; Nicorici, D; Kronenwett, U; Rathnagiriswaran, S; Mettu, RKR; Ma, Y; Kruger, S; Bruch, HP; Auer, G; Guo, NL; Ried, T,期刊:International Journal of Cancer, 页码:1552-1564 , 文章类型: Article,,卷期:2009年124-7]
- Recently, expression profiling of breast carcinomas has revealed gene signatures that predict clinical outcome, and discerned prognostically relevant breast cancer subtypes. Measurement of the degree of genomic instabili...
- Frequent concomitant epigenetic silencing of the stress-responsive tumor suppressor gene CADM1, and its interacting partner DAL-1 in nasal NK/T-cell lymphoma
[作者:Fu, L; Gao, ZF; Zhang, XH; Tsang, YH; Goh, HK; Geng, H; Shimizu, N; Tsuchiyama, J; Srivastava, G; Tao, Q,期刊:International Journal of Cancer, 页码:1572-1578 , 文章类型: Article,,卷期:2009年124-7]
- Nasal NK/T-cell lymphoma (NL) is a rare but clinically important entity of lymphoma. Its preferential incidence in Orientals but not Caucasians suggests possible genetic predisposition. 11q deletion is common in NL, indi...
- Downregulation of vascular endothelial growth factor and induction of tumor dormancy by 15-lipoxygenase-2 in prostate cancer
[作者:Tang, Y; Wang, MT; Chen, YK; Yang, D; Che, MX; Honn, KV; Akers, GD; Johnson, SR; Nie, D,期刊:International Journal of Cancer, 页码:1545-1551 , 文章类型: Article,,卷期:2009年124-7]
- The enzyme 15-lipoxygenase-2 (15-LOX-2) utilizes arachidonic acid, a polyunsaturated fatty acid, to synthesize 15(S)-hydroxycosatetraenoic acid. Abundantly expressed in normal prostate epithelium but frequently suppresse...
- Interferon-gamma down-regulates NKG2D ligand expression and impairs the NKG2D-mediated cytolysis of MHC class I-deficient melanoma by natural killer cells
[作者:Schwinn, N; Vokhminova, D; Sucker, A; Textor, S; Striegel, S; Moll, I; Nausch, N; Tuettenberg, J; Steinle, A; Cerwenka, A; Schadendorf, D; Paschen, A,期刊:International Journal of Cancer, 页码:1594-1604 , 文章类型: Article,,卷期:2009年124-7]
- NKG2D operates as an activating receptor on natural killer (NK) cells and costimulates the effector function of alpha p CD8(+) T cells. Ligands of NKG2D, the MHC class I chain-related (MIC) and UL16 binding protein (ULBP...
- An intron 4 VNTR polymorphism of the endothelial nitric oxide synthase gene is associated with early-onset colorectal cancer
[作者:Yeh, CC; Santella, RM; Hsieh, LL; Sung, FC; Tang, RP,期刊:International Journal of Cancer, 页码:1565-1571 , 文章类型: Article,,卷期:2009年124-7]
- Endothelial-derived nitric oxide, which is produced by endothelial nitric oxide synthase (eNOS), may play an important role in colorectal carcinogenesis. However, the putative contribution of common eNOS genetic polymorp...
- The clonal evolution of metastases from primary serous epithelial ovarian cancers
[作者:Khalique, L; Ayhan, A; Whittaker, JC; Singh, N; Jocobs, IJ; Gayther, SA; Ramus, SJ,期刊:International Journal of Cancer, 页码:1579-1586 , 文章类型: Article,,卷期:2009年124-7]
- Several models of evolution from primary cancers to metastases have been proposed; but the most widely accepted is the clonal evolution model proposed for colorectal cancer in which tumors develop by a process of linear ...
- Downregulation of ZIP kinase is associated with tumor invasion, metastasis and poor prognosis in gastric cancer
[作者:Bi, J; Lau, SH; Hu, L; Rao, HL; Liu, HB; Zhan, WH; Chen, G; Wen, JM; Wang, Q; Li, B; Guan, XY,期刊:International Journal of Cancer, 页码:1587-1593 , 文章类型: Article,,卷期:2009年124-7]
- Deletion of 19p13 is one of the most frequent genetic changes in gastric carcinoma (GC), implying the existence of a tumor suppressor gene (TSG) that plays an important role in GC development. To identify the candidate T...
- Proteomic profiling in pancreatic cancer with and without lymph node metastasis
[作者:Cui, YZ; Wu, JM; Zong, MJ; Song, GH; Jia, Q; Jiang, JB; Han, JX,期刊:International Journal of Cancer, 页码:1614-1621 , 文章类型: Article,,卷期:2009年124-7]
- The aim of the study was to observe different protein profiles in pancreatic cancer with and without lymph node metastasis (LNM), and search for novel LNM-associated proteins, which would help to understand the metastati...
- Cancer patterns in nasopharyngeal carcinoma multiplex families in Taiwan
[作者:Yu, KJ; Hsu, WL; Chiang, CJ; Cheng, YJ; Pfeiffer, RM; Diehl, SR; Goldstein, AM; Gravitt, PE; Chen, CJ; Hildesheim, A,期刊:International Journal of Cancer, 页码:1622-1625 , 文章类型: Article,,卷期:2009年124-7]
- Genetic and environmental factors have been implicated in the etiology of nasopharyngeal carcinoma (NPC), a tumor known to be closely associated with Epstein-Barr virus (EBV) infection. Studies have reported familial agg...
- Prevalence and type distribution of human papillomavirus in carcinoma and intraepithelial neoplasia of the vulva, vagina and anus: A meta-analysis
[作者:De Vuyst, H; Clifford, GM; Nascimento, MC; Madeleine, MM; Franceschi, S,期刊:International Journal of Cancer, 页码:1626-1636 , 文章类型: Article,,卷期:2009年124-7]
- This meta-analysis investigated human papillomavirus (HPV) prevalence in vulvar, vaginal and anal intraepithelial neoplasia (VIN, VAIN, AIN) grades 1-3 and carcinoma from 93 studies conducted in 4 continents and using PC...
- Telomere length, oxidative damage, antioxidants and breast cancer risk
[作者:Shen, J; Gammon, MD; Terry, MB; Wang, Q; Bradshaw, P; Teitelbaum, SL; Neugut, AI; Santella, RM,期刊:International Journal of Cancer, 页码:1637-1643 , 文章类型: Article,,卷期:2009年124-7]
- Telomeres play a critical role in maintaining the integrity and stability of the genome, and are susceptible to oxidative damage after telomere shortening to a critical length. In the present study, we explored the role ...
- Isoflavone consumption and subsequent risk of hepatocellular carcinoma in a population-based prospective cohort of Japanese men and women
[作者:Kurahashi, N; Inoue, M; Iwasaki, M; Tanaka, Y; Mizokami, M; Tsugane, S,期刊:International Journal of Cancer, 页码:1644-1649 , 文章类型: Article,,卷期:2009年124-7]
- The incidence of hepatocellular carcinoma (HCC) is much higher in men than in women. Several experiment and epidemiological studies have suggested that estrogen might play an inhibitory role in the development of HCC. Be...
- Higher regular coffee and tea consumption is associated with reduced endometrial cancer risk
[作者:McCann, SE; Yeh, M; Rodabaugh, K; Moysich, KB,期刊:International Journal of Cancer, 页码:1650-1653 , 文章类型: Article,,卷期:2009年124-7]
- Several studies have investigated the associations between diet and endometrial cancer, but few have focused specifically on coffee and tea. In a hospital-based case-control study, we examined the associations between en...
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