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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共8条记录   Potential dual role of KGF/KGFR as a target option in novel therapeutic strategies for the treatment of cancers and mucosal damages [作者：Ceccarelli, S; Romano, F; Angeloni, A; Marchese, C,期刊：Expert Opinion on Therapeutic Targets, 页码：377-393 , 文章类型： Review，,卷期：2012年16-4] Introduction: Keratinocyte growth factor (KGF) and its receptor KGFR play a pivotal role in regulating cell proliferation, migration, differentiation and survival, in response to injury and tissue repair. Altered express... Targeting VEGF in lung cancer [作者：Das, M; Wakelee, H,期刊：Expert Opinion on Therapeutic Targets, 页码：395-406 , 文章类型： Review，,卷期：2012年16-4] Introduction: VEGF promotes tumor angiogenesis and is an important target in various malignancies, including NSCLC. Areas covered: Here, the authors review the data that led to the approval of bevacizumab, a monoclonal a... The therapeutic potential of the endocannabinoid system for Alzheimer's disease [作者：Karl, T; Cheng, D; Garner, B; Arnold, JC,期刊：Expert Opinion on Therapeutic Targets, 页码：407-420 , 文章类型： Review，,卷期：2012年16-4] Introduction: Dementia currently affects over 35 million people worldwide. The most common form of dementia is Alzheimer's disease (AD). Currently, treatments for AD do not stop or reverse the progression of the disease ... Targeting intracellular and extracellular alpha-synuclein as a therapeutic strategy in Parkinson's disease and other synucleinopathies [作者：Vekrellis, K; Stefanis, L,期刊：Expert Opinion on Therapeutic Targets, 页码：421-432 , 文章类型： Review，,卷期：2012年16-4] Introduction: alpha-Synuclein is a neuronal presynaptic protein that regulates neurotransmitter release. Genetic, neuropathological, biochemical and animal model data indicate that it plays a major role in Parkinson's di... Exploiting the therapeutic potential of microRNAs in human cancer [作者：Cho, WCS,期刊：Expert Opinion on Therapeutic Targets, 页码：345-350 , 文章类型： Editorial Material，,卷期：2012年16-4] Dysregulation of microRNAs (miRNAs) has been widely shown to be associated with the development and progression of cancer. Recent studies discovered a handful of miRNAs with great potential to act as therapeutic targets ... Bioenergetics failure in neurodegenerative diseases: back to the future [作者：Saxena, U,期刊：Expert Opinion on Therapeutic Targets, 页码：351-354 , 文章类型： Editorial Material，,卷期：2012年16-4] Neurodegenerative disease such as Alzheimer's, Parkinson and Huntington's are all characterized by dysfunctional neurons and loss of cognitive/motor functions. Interestingly these three diseases involve overproduction, a... Targeting RhoA/ROCK pathway in pulmonary arterial hypertension [作者：Antoniu, SA,期刊：Expert Opinion on Therapeutic Targets, 页码：355-363 , 文章类型： Review，,卷期：2012年16-4] Introduction: Pulmonary arterial hypertension (PAH) is a rare disease with a complex pathogenesis. It is often associated with an increased vascular resistance, whilst in the more advanced stages there is a remodelling o... Targeting angiogenesis for the treatment of prostate cancer [作者：Antonarakis, ES; Carducci, MA,期刊：Expert Opinion on Therapeutic Targets, 页码：365-376 , 文章类型： Review，,卷期：2012年16-4] Introduction: While multiple therapies exist that prolong the lives of men with advanced prostate cancer, none are curative. This had led to a search to uncover novel targets for prostate cancer therapy, distinct from th...