- CaMK-II is a PKD2 target that promotes pronephric kidney development and stabilizes cilia
[作者:Rothschild, SC; Francescatto, L; Drummond, IA; Tombes, RM,期刊:Development, 页码:3387-3397 , 文章类型: Article,,卷期:2011年138-16]
- Intracellular Ca2+ signals influence gastrulation, neurogenesis and organogenesis through pathways that are still being defined. One potential Ca2+ mediator of many of these morphogenic processes is CaMK-II, a conserved ...
- Specific and integrated roles of Lmx1a, Lmx1b and Phox2a in ventral midbrain development
[作者:Deng, QL; Andersson, E; Hedlund, E; Alekseenko, Z; Coppola, E; Panman, L; Millonig, JH; Brunet, JF; Ericson, J; Perlmann, T,期刊:Development, 页码:3399-3408 , 文章类型: Article,,卷期:2011年138-16]
- The severe disorders associated with a loss or dysfunction of midbrain dopamine neurons (DNs) have intensified research aimed at deciphering developmental programs controlling midbrain development. The homeodomain protei...
- Female gametophytic cell specification and seed development require the function of the putative Arabidopsis INCENP ortholog WYRD
[作者:Kirioukhova, O; Johnston, AJ; Kleen, D; Kagi, C; Baskar, R; Moore, JM; Baumlein, H; Gross-Hardt, R; Grossniklaus, U,期刊:Development, 页码:3409-3420 , 文章类型: Article,,卷期:2011年138-16]
- In plants, gametes, along with accessory cells, are formed by the haploid gametophytes through a series of mitotic divisions, cell specification and differentiation events. How the cells in the female gametophyte of flow...
- The regenerative capacity of zebrafish reverses cardiac failure caused by genetic cardiomyocyte depletion
[作者:Wang, JH; Panakova, D; Kikuchi, K; Holdway, JE; Gemberling, M; Burris, JS; Singh, SP; Dickson, AL; Lin, YF; Sabeh, MK; Werdich, AA; Yelon, D; MacRae, CA; Poss, KD,期刊:Development, 页码:3421-3430 , 文章类型: Article,,卷期:2011年138-16]
- Natural models of heart regeneration in lower vertebrates such as zebrafish are based on invasive surgeries causing mechanical injuries that are limited in size. Here, we created a genetic cell ablation model in zebrafis...
- Notch signaling prevents mucous metaplasia in mouse conducting airways during postnatal development
[作者:Tsao, PN; Wei, SC; Wu, MF; Huang, MT; Lin, HY; Lee, MC; Lin, KMC; Wang, IJ; Kaartinen, V; Yang, LT; Cardoso, WV,期刊:Development, 页码:3533-3543 , 文章类型: Article,,卷期:2011年138-16]
- Goblet cell metaplasia and mucus overproduction contribute to the pathogenesis of chronic lung diseases, including asthma and chronic obstructive pulmonary disease (COPD). Notch signaling regulates cell fate decisions an...
- Notch and Ras promote sequential steps of excretory tube development in C. elegans
[作者:Abdus-Saboor, I; Mancuso, VP; Murray, JI; Palozola, K; Norris, C; Hall, DH; Howell, K; Huang, K; Sundaram, MV,期刊:Development, 页码:3545-3555 , 文章类型: Article,,卷期:2011年138-16]
- Receptor tyrosine kinases and Notch are crucial for tube formation and branching morphogenesis in many systems, but the specific cellular processes that require signaling are poorly understood. Here we describe sequentia...
- Concerted involvement of Cdx/Hox genes and Wnt signaling in morphogenesis of the caudal neural tube and cloacal derivatives from the posterior growth zone
[作者:van de Ven, C; Bialecka, M; Neijts, R; Young, T; Rowland, JE; Stringer, EJ; van Rooijen, C; Meijlink, F; Novoa, A; Freund, JN; Mallo, M; Beck, F; Deschamps, J,期刊:Development, 页码:3451-3462 , 文章类型: Article,,卷期:2011年138-16]
- Decrease in Cdx dosage in an allelic series of mouse Cdx mutants leads to progressively more severe posterior vertebral defects. These defects are corrected by posterior gain of function of the Wnt effector Lef1. Precoci...
- Modulation of cell-cycle dynamics is required to regulate the number of cerebellar GABAergic interneurons and their rhythm of maturation
[作者:Leto, K; Bartolini, A; Di Gregorio, A; Imperiale, D; De Luca, A; Parmigiani, E; Filipkowski, RK; Kaczmarek, L; Rossi, F,期刊:Development, 页码:3463-3472 , 文章类型: Article,,卷期:2011年138-16]
- The progenitors of cerebellar GABAergic interneurons proliferate up to postnatal development in the prospective white matter, where they give rise to different neuronal subtypes, in defined quantities and according to pr...
- Fgf signaling controls pharyngeal taste bud formation through miR-200 and Delta-Notch activity
[作者:Kapsimali, M; Kaushik, AL; Gibon, G; Dirian, L; Ernest, S; Rosa, FM,期刊:Development, 页码:3473-3484 , 文章类型: Article,,卷期:2011年138-16]
- Taste buds, the taste sensory organs, are conserved in vertebrates and composed of distinct cell types, including taste receptor, basal/presynaptic and support cells. Here, we characterize zebrafish taste bud development...
- Ethylene inhibits lateral root development, increases IAA transport and expression of PIN3 and PIN7 auxin efflux carriers
[作者:Lewis, DR; Negi, S; Sukumar, P; Muday, GK,期刊:Development, 页码:3485-3495 , 文章类型: Article,,卷期:2011年138-16]
- We used genetic and molecular approaches to identify mechanisms by which the gaseous plant hormone ethylene reduces lateral root formation and enhances polar transport of the hormone auxin. Arabidopsis thaliana mutants, ...
- Microtubule-based localization of a synaptic calcium-signaling complex is required for left-right neuronal asymmetry in C. elegans
[作者:Chang, C; Hsieh, YW; Lesch, BJ; Bargmann, CI; Chuang, CF,期刊:Development, 页码:3509-3518 , 文章类型: Article,,卷期:2011年138-16]
- The axons of C. elegans left and right AWC olfactory neurons communicate at synapses through a calcium-signaling complex to regulate stochastic asymmetric cell identities called AWC(ON) and AWC(OFF). However, it is not k...
- An emerging role for TOR signaling in mammalian tissue and stem cell physiology
[作者:Russell, RC; Fang, C; Guan, KL,期刊:Development, 页码:3343-3356 , 文章类型: Review,,卷期:2011年138-16]
- The mammalian target of rapamycin (mTOR) is a kinase that responds to a myriad of signals, ranging from nutrient availability and energy status, to cellular stressors, oxygen sensors and growth factors. The finely tuned ...
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