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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共14条记录   Optimization of Pharmacokinetics through Manipulation of Physicochemical Properties in a Series of HCV Inhibitors [作者：LAZERWITH SCOTT E; BAHADOR GINA; CANALES EDA; CHENG GUOFENG; CHONG LEE; CLARKE MICHAEL O; DOERFFLER EDWARD; EISENBERG EUGENE J; HAYES JACLYN; LU BING; LIU QI; MATLES MIKE; MERTZMAN MICHAEL; MITCHELL MICHAEL L; MORGANELLI PHILIP; MURRAY BERNARD P; ROBINSON MARGARET; STRICKLEY ROBERT G; TESSLER MEGAN; TIRUNAGARI NEERAJ; WANG JIANHONG; WANG YUJIN; ZHANG JENNIFER R; ZHENG XUBIN; ZHONG WEIDONG; WATKINS WILLIAM J,期刊：ACS Medicinal Chemistry Letters, 页码：715-719 , 文章类型： Article，,卷期：2011年2-10] A novel series of HCV replication inhibitors based on a pyrido[3,2-d]primidine core were optimized for pharmacokinetics (PK) in rats. Several associations between physicochemical properties and PK were identified and exp... 3D Pharmacophore Model-Assisted Discovery of Novel CDC7 Inhibitors [作者：LINDVALL MIKA; MCBRIDE CHRISTOPHER; MCKENNA MAUREEN; GESNER THOMAS G; YABANNAVAR ASHA; WONG KENT; LIN SONG; WALTER ANNETTE; SHAFER CYNTHIA M,期刊：ACS Medicinal Chemistry Letters, 页码：720-723 , 文章类型： Article，,卷期：2011年2-10] A ligand-based 3D pharmacophore model for serine/threonine kinase CDC7 inhibition was created and successfully applied in the discovery of novel 2-(heteroaryl)-6,7-dihydrothieno[3,2-c]pyridin-4(5H)-ones. The pharmacophor... Exploiting Fluorescence Lifetime Plasticity in FLIM: Target Molecule Localization in Cells and Tissues [作者：BOREHAM A; KIM T Y; SPAHN V; STEIN C; MUNDHENK L; GRUBER A D; HAAG R; WELKER P; LICHA K; ALEXIEV U,期刊：ACS Medicinal Chemistry Letters, 页码：724-728 , 文章类型： Article，,卷期：2011年2-10] The mechanisms of drug-receptor interactions and the controlled delivery of drugs via biodegradable and biocompatible nanoparticulate carriers are active research fields in nanomedicine. Many clinically used drugs target... Structure-Based Ligand Design of Novel Bacterial RNA Polymerase Inhibitors [作者：MCPHILLIE MARTIN J; TROWBRIDGE RACHEL; MARINER KATHERINE R; ONEILL ALEX J; JOHNSON A PETER; CHOPRA IAN; FISHWICK COLIN W G,期刊：ACS Medicinal Chemistry Letters, 页码：729-734 , 文章类型： Article，,卷期：2011年2-10] Bacterial RNA polymerase (RNAP) is essential for transcription and is an antibacterial target for small molecule inhibitors. The binding region of myxopyronin B (MyxB), a bacterial RNAP inhibitor, offers the possibility ... Monoenomycin: A Simplified Trienomycin A Analogue That Manifests Anticancer Activity [作者：BRANDT GARY E L; BLAGG BRIAN S J,期刊：ACS Medicinal Chemistry Letters, 页码：735-740 , 文章类型： Article，,卷期：2011年2-10] Macrocydic natural products are a powerful class of leadlike chemical entities. Despite commonly violating Lipinski's "rule of 5", these compounds often demonstrate superior druglike physicochemical and pharmacokinetic a... An Invitation to Open Innovation in Malaria Drug Discovery: 47 Quality Starting Points from the TCAMS [作者：CALDERON FELIX; BARROS DAVID; MARIA BUENO JOSE; MIGUEL COTERON JOSE; FERNANDEZ ESTHER; JAVIER GAMO FRANCISCO; LUIS LAVANDERA JOSE; LUISA LEON MARIA; MACDONALD SIMON J F; MALLO ARACELI; MANZANO PILAR; PORRAS ESTHER; MARIA FIANDOR JOSE; CASTRO JULIA,期刊：ACS Medicinal Chemistry Letters, 页码：741-746 , 文章类型： Article，,卷期：2011年2-10] In 2010, GlaxoSmithKline published the structures of 13533 chemical starting points for antimalarial lead identification. By using an agglomerative structural clustering technique followed by computational filters such a... Discovery of VTP-27999, an Alkyl Amine Renin Inhibitor with Potential for Clinical Utility [作者：JIA LANQI; SIMPSON ROBERT D; YUAN JING; XU ZHENRONG; ZHAO WEI; CACATIAN SALVACION; TICE COLIN M; GUO JOAN; ISHCHENKO ALEXEY; SINGH SURESH B; WU ZHONGREN; MCKEEVER BRIAN M; BUKHTIYAROV YURI; JOHNSON JUDITH A; DOE CHRISTOPHER P; HARRISON RICHARD K; MCGEEHAN GERARD M; DILLARD LAWRENCE W; BALDWIN JOHN J; CLAREMON DAVID A,期刊：ACS Medicinal Chemistry Letters, 页码：747-751 , 文章类型： Article，,卷期：2011年2-10] Structure guided optimization of a series of nonpeptidic alkyl amine renin inhibitors allowed the rational incorporation of additional polar functionality. Replacement of the c-yclohexylmethyl group occupying the SI pock... 4-Methoxy-N-[2-(trifluoromethyl)biphenyl-4-ylcarbamoyl]nicotinamide: A Potent and Selective Agonist of S1P(1) [作者：PENNINGTON LEWIS D; SHAM KELVIN K C; PICKRELL ALEXANDER J; HARRINGTON PAUL E; FROHN MICHAEL J; LANMAN BRIAN A; REED ANTHONY B; CROGHAN MICHAEL D; LEE MATTHEW R; XU HAN; MCELVAIN MICHELE; XU YANG; ZHANG XUXIA; FIORINO MICHAEL; HORNER MICHELLE; MORRISON HENRY G; ARNETT HEATHER A; FOTSCH CHRISTOPHER; WONG MIN; CEE VICTOR J,期刊：ACS Medicinal Chemistry Letters, 页码：752-757 , 文章类型： Article，,卷期：2011年2-10] The sphingosine-1-phosphate-1 receptor (S1P(1)) and its endogenous ligand sphingosine-1-phosphate (S1P) cooperatively regulate lymphocyte trafficking from the lymphatic system. Herein, we disclose 4-methoxy-N[2-(trifluor... The Discovery of VX-745: A Novel and Selective p38 alpha Kinase Inhibitor [作者：DUFFY JOHN P; HARRINGTON EDMUND M; SALITURO FRANCESCO G; COCHRAN JOHN E; GREEN JEREMY; GAO HUAI; BEMIS GUY W; EVINDAR GHOTAS; GALULLO VINCENT P; FORD PAMELLA J; GERMANN URSULA A; WILSON KEITH P; BELLON STEVEN F; CHEN GUANGING; TASLIMI PAUL; JONES PETER; HUANG CASSEY; PAZHANISAMY S; WANG YOWMING; MURCKO MARK A; SU MICHAEL S S,期刊：ACS Medicinal Chemistry Letters, 页码：758-763 , 文章类型： Article，,卷期：2011年2-10] The synthesis of novel, selective, orally active 2,5-disubstituted 6H-pyrimido[1,6-b]pyridazin-6-one p38 alpha inhibitors is described. Application of structural information from enzyme-ligand complexes guided the select... Exploiting the P-1 Pocket of BRCT Domains Toward a Structure Guided Inhibitor Design [作者：YUAN ZIYAN; KUMAR ERIC A; CAMPBELL STEPHEN J; PALERMO NICHOLAS Y; KIZHAKE SMITHA; GLOVER J N MARK; NATARAJAN AMARNATH,期刊：ACS Medicinal Chemistry Letters, 页码：764-767 , 文章类型： Article，,卷期：2011年2-10] Breast cancer gene 1 carboxy terminus (BRCT) domains are found in a number of proteins that are important for DNA damage response (DDR). The BRCT domains bind phosphorylated proteins, and these protein-protein interactio... Aryltriflates as a Neglected Moiety in Medicinal Chemistry: A Case Study from a Lead Optimization of CXCL8 Inhibitors [作者：MORICONI ALESSIO; BIGOGNO CHIARA; BIANCHINI GIANLUCA; CALIGIURI ANTONIO; RESCONI ANNA; DONDIO MASSIMO G; DANNIBALLE GAETANO; ALLEGRETTI MARCELLO,期刊：ACS Medicinal Chemistry Letters, 页码：768-773 , 文章类型： Article，,卷期：2011年2-10] Interleukin-8 and growth related oncogene-alpha-chemokines (formerly CXCL8 and CXCL1, respectively) mediate chemotaxis of neutrophils to inflammatory sites via interactions with two transmembrane receptors, the type A CX... Identification of NVP-BKM120 as a Potent, Selective, Orally Bioavailable Class I PI3 Kinase Inhibitor for Treating Cancer [作者：BURGER MATTHEW T; PECCHI SABINA; WAGMAN ALLAN; NI ZHIJIE; KNAPP MARK; HENDRICKSON THOMAS; ATALLAH GORDANA; PFISTER KEITH; ZHANG YANCHEN; BARTULIS SARAH; FRAZIER KELLY; NG SIMON; SMITH AARON; VERHAGEN JOELLE; HAZNEDAR JOSHUA; HUH KAY; IWANOWICZ ED; XIN XIAOHUA; MENEZES DANIEL; MERRITT HANNE; LEE ISABELLE; WIESMANN MARION; KAUFMAN SUSAN; CRAWFORD KENNETH; CHIN MICHAEL; BUSSIERE DIRKSEN; SHOEMAKER KEVIN; ZAROR ISABEL; MAIRA SAUVEURMICHEL; VOLIVA CHARLES F,期刊：ACS Medicinal Chemistry Letters, 页码：774-779 , 文章类型： Article，,卷期：2011年2-10] Phosphoinositide-3-kinases (PI3Ks) are important oncology targets due to the deregulation of this signaling pathway in a wide variety of human cancers. Herein we describe the structure guided optimization of a series of ... Identification of Inhibitors of NOD1-Induced Nuclear Factor-kappa B Activation [作者：KHAN PASHA M; CORREA RICARDO G; DIVLIANSKA DANIELA B; PEDDIBHOTLA SATYAMAHESHWAR; SESSIONS E HAMPTON; MAGNUSON GAVIN; BROWN BROCK; SUYAMA EIGO; YUAN HONGBIN; MANGRAVITANOVO ARIANNA; VICCHIARELLI MICHAEL; SU YING; VASILE STEFAN; SMITH LAYTON H; DIAZ PAUL W; REED JOHN C; ROTH GREGORY P,期刊：ACS Medicinal Chemistry Letters, 页码：780-785 , 文章类型： Article，,卷期：2011年2-10] NOD1 (nucleotide-binding oligomerization domain 1) protein is a member of the NLR (NACHT and leucine rich repeat domain containing proteins) protein family, which plays a key role in innate immunity as a sensor of specif... Discovery of BIIB042, a Potent, Selective, and Orally Bioavailable gamma-Secretase Modulator [作者：PENG HAIRUO; TALREJA TINA; XIN ZHILI; CUERVO J HERNAN; KUMARAVEL GNANASAMBANDAM; HUMORA MICHAEL J; XU LIN; ROHDE ELLEN; GAN LAWRENCE; JUNG MIYOUNG; SHACKETT MELANIE N; CHOLLATE SOWMYA; DUNAH ANTHONE W; SNODGRASSBELT PAMELA A; ARNOLD H MOORE; TAVERAS ARTHUR G; RHODES KENNETH J; SCANNEVIN ROBERT H,期刊：ACS Medicinal Chemistry Letters, 页码：786-791 , 文章类型： Article，,卷期：2011年2-10] We have investigated a novel series of acid-derived gamma-secretase modulators as a potential treatment of Alzheimer's disease. Optimization based on cellular potency and brain pharmacodynamics after oral dosing led to t...