- Identification of CDK10 as an important determinant of resistance to endocrine therapy for breast cancer
[作者：Iorns, E; Turner, NC; Elliott, R; Syed, N; Garrone, O; Gasco, M; Tutt, ANJ; Crook, T; Lord, CJ; Ashworth, A,期刊：Cancer Cell, 页码：91-104 , 文章类型： Article，,卷期：2008年13-2]
- Therapies that target estrogen signaling have transformed the treatment of breast cancer. However, the effectiveness of these agents is limited by the development of resistance. Here, an RNAi screen was used to identify ...
- Plexiform and dermal neurofibromas and pigmentation are caused by Nf1 loss in desert hedgehog-expressing cells
[作者：Wu, JQ; Williams, JP; Rizvi, TA; Kordich, JJ; Witte, D; Meijer, D; Stemmer-Rachamimov, AO; Cancelas, JA; Ratner, N,期刊：Cancer Cell, 页码：105-116 , 文章类型： Article，,卷期：2008年13-2]
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- Induction of abnormal proliferation by nonmyelinating Schwann cells triggers neurofibroma formation
[作者：Zheng, H; Chang, L; Patel, N; Yang, J; Lowe, L; Burns, DK; Zhu, Y,期刊：Cancer Cell, 页码：117-128 , 文章类型： Article，,卷期：2008年13-2]
- Recent evidence suggests that alterations in the self-renewal program of stem/progenitor cells can cause tumorigenesis. By utilizing genetically engineered mouse models of neurofibromatosis type 1 (NF1), we demonstrated ...
- The loss of Nf1 transiently promotes self-renewal but not tumorigenesis by neural crest stem cells
[作者：Joseph, NM; Mosher, JT; Buchstaller, J; Snider, P; McKeever, PE; Lim, M; Conway, SJ; Parada, LF; Zhu, Y; Morrison, SJ,期刊：Cancer Cell, 页码：129-140 , 文章类型： Article，,卷期：2008年13-2]
- Neurofibromatosis is caused by the loss of neurofibromin (Nf1), leading to peripheral nervous system (PNS) tumors, including neurofibromas and malignant peripheral nerve sheath tumors (MPNSTs). A long-standing question h...
- GATA-3 links tumor differentiation and dissemination in a luminal breast cancer model
[作者：Kouros-Mehr, H; Bechis, SK; Slorach, EM; Littlepage, LE; Egeblad, M; Ewald, AJ; Pai, SY; Ho, IC; Werb, Z,期刊：Cancer Cell, 页码：141-152 , 文章类型： Article，,卷期：2008年13-2]
- How breast cancers are able to disseminate and metastasize is poorly understood. Using a hyperplasia transplant system, we show that tumor dissemination and metastasis occur in discrete steps during tumor progression. Bi...
- Significance of CD90(+) cancer stem cells in human liver cancer
[作者：Yang, ZF; Ho, DW; Ng, MN; Lau, CK; Yu, WC; Ngai, P; Chu, PWK; Lam, CT; Poon, RTP; Fan, ST,期刊：Cancer Cell, 页码：153-166 , 文章类型： Article，,卷期：2008年13-2]
- This study characterized cancer stem cells (CSCs) in hepatocellular carcinoma (HCC) cell lines, tumor specimens, and blood samples. The CD90(+) cells, but not the CD90(-) cells, from HCC cell lines displayed tumorigenic ...
- AID-dependent activation of a MYC transgene induces multiple myeloma in a conditional mouse model of post-germinal center malignancies
[作者：Chesi, M; Robbiani, DF; Sebag, M; Chng, WJ; Affer, M; Tiedemann, R; Valdez, R; Palmer, SE; Haas, SS; Stewart, AK; Fonseca, R; Kremer, R; Cattoretti, G; Bergsagel, PL,期刊：Cancer Cell, 页码：167-180 , 文章类型： Article，,卷期：2008年13-2]
- By misdirecting the activity of Activation-Induced Deaminase (AID) to a conditional MYC transgene, we have achieved sporadic, AID-dependent MYC activation in germinal center B cells of Vk*MYC mice. Whereas control C57BL/...
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