个性化文献订阅>文章检索

文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共12条记录   Microenvironment determines lineage fate in a human model of MLL-AF9 leukemia [作者：Wei, J; Wunderlich, M; Fox, C; Alvarez, S; Cigudosa, JC; Wilhelm, JS; Zheng, Y; Cancelas, JA; Gu, Y; Jansen, M; DiMartino, JF; Mulloy, JC,期刊：Cancer Cell, 页码：483-495 , 文章类型： Article，,卷期：2008年13-6] Faithful modeling of mixed-lineage leukemia in murine cells has been difficult to achieve. We show that expression of MLL-AF9 in human CD34+ cells induces acute myeloid, lymphoid, or mixed-lineage leukemia in immunodefic... Genetic and epigenetic silencing of microRNA-203 enhances ABL1 and BCR-ABL1 oncogene expression [作者：Bueno, MJ; de Castro, IP; de Cedron, MG; Santos, J; Calin, GA; Cigudosa, JC; Croce, CM; Fernandez-Piqueras, J; Malumbres, M,期刊：Cancer Cell, 页码：496-506 , 文章类型： Article，,卷期：2008年13-6] The mammalian genome contains several hundred microRNAs that regulate gene expression through modulation of target mRNAs. Here, we report a fragile chromosomal region lost in specific hematopoietic malignancies. This 7 M... TNFR1 signaling and IFN-gamma signaling determine whether T cells induce tumor dormancy or promote multistage carcinogenesis [作者：Mueller-Hermelink, N; Braumuller, H; Pichler, B; Wieder, T; Mailhammer, R; Schaak, K; Ghoreschi, K; Yazdi, A; Haubner, R; Sander, CA; Mocikat, R; Schwaiger, M; Forster, I; Huss, R; Weber, WA; Kneilling, M; Rocken, M,期刊：Cancer Cell, 页码：507-518 , 文章类型： Article，,卷期：2008年13-6] Immune responses may arrest tumor growth by inducing tumor dormancy. The mechanisms leading to either tumor dormancy or promotion of multistage carcinogenesis by adaptive immunity are poorly characterized. Analyzing T an... The role of SPINK1 in ETS rearrangement-negative prostate cancers [作者：Tomlins, SA; Rhodes, DR; Yu, JJ; Varambally, S; Mehra, R; Perner, S; Demichelis, F; Helgeson, BE; Laxman, B; Morris, DS; Cao, Q; Cao, XH; Andren, O; Fall, K; Johnson, L; Wei, JT; Shah, RB; Al-Ahmadie, H; Eastham, JA; Eggener, SE; Fine, SW; Hotakainen, K; Stenman, UH; Tsodikov, A; Gerald, WL; Lilja, H; Reuter, VE; Kantoff, PW; Scardino, PT; Rubin, MA; Bjartell, AS; Chinnaiyan, AM,期刊：Cancer Cell, 页码：519-528 , 文章类型： Article，,卷期：2008年13-6] ETS gene fusions have been characterized in a majority of prostate cancers; however, the key molecular alterations in ETS-negative cancers are unclear. Here we used an outlier meta-analysis (meta-COPA) to identify SPINK1... DACT3 is an epigenetic regulator of Wnt/beta-catenin signaling in colorectal cancer and is a therapeutic target of histone modifications [作者：Jiang, X; Tan, J; Li, JS; Kivimaee, S; Yang, XJ; Zhuang, L; Lee, PL; Chan, MTW; Stanton, LW; Liu, ET; Cheyette, BNR; Yu, Q,期刊：Cancer Cell, 页码：529-541 , 文章类型： Article，,卷期：2008年13-6] Genetic and epigenetic defects in Wnt/beta-catenin signaling play important roles in colorectal cancer progression. Here we identify DACT3, a member of the DACT (Dpr/Frodo) gene family, as a negative regulator of Wnt/bet... Mitochondrial p32 is a critical mediator of ARF-induced apoptosis [作者：Itahana, K; Zhang, YP,期刊：Cancer Cell, 页码：542-553 , 文章类型： Article，,卷期：2008年13-6] The shared exon 2 of the p14ARF-p16INK4a locus is frequently mutated in human cancers. However, in contrast to the exon 1 beta-encoded N-terminal half of ARF, the function of the exon 2-encoded C-terminal half of ARF has... MLL-AF9 leukemia stem cells: Hardwired or taking cues from the microenvironment? [作者：Muntean, AG; Hess, JL,期刊：Cancer Cell, 页码：465-467 , 文章类型： Editorial Material，,卷期：2008年13-6] MLL rearrangements in humans lead to both acute myeloid leukemia (AML) and acute lymphoid leukemia (ALL). While AML has been successfully produced in mice, modeling ALL has been more difficult. In this issue of Cancer Ce... Linking miRNA regulation to BCR-ABL expression: The next dimension [作者：Faber, J; Gregory, RI; Armstrong, SA,期刊：Cancer Cell, 页码：467-469 , 文章类型： Editorial Material，,卷期：2008年13-6] The introduction of tyrosine kinase inhibitors in the treatment of BCR-ABL1-rearranged malignancies has revolutionized therapy, but the prognosis for acute leukemias remains suboptimal. In this issue of Cancer Cell, Buen... The ups and downs of Src regulation: Tumor suppression by Cbp [作者：Resh, MD,期刊：Cancer Cell, 页码：469-471 , 文章类型： Editorial Material，,卷期：2008年13-6] Tight control of the tyrosine kinase activity of c-Src is critical for regulating its oncogenic potential. In a recent issue of Molecular Cell, Oneyama et al. (2008a) report that the membrane-bound adaptor protein Cbp (a... VEGFR-3 expression is restricted to blood and lymphatic vessels in solid tumors [作者：Petrova, TV; Bono, P; Holnthoner, W; Chesnes, J; Pytowski, B; Sihto, H; Laakkonen, P; Heikkila, P; Joensuu, H; Alitalo, K,期刊：Cancer Cell, 页码：554-556 , 文章类型： Letter，,卷期：2008年13-6] Further evidence for expression and function of the VEGF-C/VEGFR-3 axis in cancer cells [作者：Su, JL; Chen, PS; Chien, MH; Chen, PB; Chen, YH; Lai, CC; Hung, MC; Kuo, ML,期刊：Cancer Cell, 页码：557-560 , 文章类型： Letter，,卷期：2008年13-6] Tumor cell metabolism: Cancer's Achilles' heel [作者：Kroemer, G; Pouyssegur, J,期刊：Cancer Cell, 页码：472-482 , 文章类型： Review，,卷期：2008年13-6] The essential hallmarks of cancer are intertwined with an altered cancer cell-intrinsic metabolism, either as a consequence or as a cause. As an example, the resistance of cancer mitochondria against apoptosis-associated...