- Argyrin A reveals a critical role for the tumor suppressor protein p27(kip1) in mediating antitumor activities in response to proteasome inhibition
[作者:Nickeleit, I; Zender, S; Sasse, F; Geffers, R; Brandes, G; Sorensen, I; Steinmetz, H; Kubicka, S; Carlomagno, T; Menche, D; Gutgemann, I; Buer, J; Gossler, A; Manns, MP; Kalesse, M; Frank, R; Malek, NP,期刊:Cancer Cell, 页码:23-35 , 文章类型: Article,,卷期:2008年14-1]
- A reduction in the cellular levels of the cyclin kinase inhibitor p27(kip1) is frequently found in many human cancers and correlates directly with patient prognosis. In this work, we identify argyrin A, a cyclical peptid...
- In childhood acute lymphoblastic leukemia, blasts at different stages of immunophenotypic maturation have stem cell properties
[作者:le Viseur, C; Hotfilder, M; Bomken, S; Wilson, K; Rottgers, S; Schrauder, A; Rosemann, A; Irving, J; Stam, RW; Shultz, LD; Harbott, J; Jurgens, H; Schrappe, M; Pieters, R; Vormoor, J,期刊:Cancer Cell, 页码:47-58 , 文章类型: Article,,卷期:2008年14-1]
- We examined the leukemic stem cell potential of blasts at different stages of maturation in childhood acute lymphoblastic leukemia (ALL). Human leukemic bone marrow was transplanted intrafemorally into NOD/scid mice. Cel...
- Loss of p21 permits carcinogenesis from chronically damaged liver and kidney epithelial cells despite unchecked apoptosis
[作者:Willenbring, H; Sharma, AD; Vogel, A; Lee, AY; Rothfuss, A; Wang, ZY; Finegold, M; Grompe, M,期刊:Cancer Cell, 页码:59-67 , 文章类型: Article,,卷期:2008年14-1]
- Accumulation of toxic metabolites in hereditary tyrosinemia type I (HT1) patients leads to chronic DNA damage and the highest risk for hepatocellular carcinomas (HCCs) of any human disease. Here we show that hepatocytes ...
- Mutations in Fbx4 inhibit dimerization of the SCFFbx4 ligase and contribute to cyclin D1 overexpression in human cancer
[作者:Barbash, O; Zamfirova, P; Lin, DI; Chen, XM; Yang, K; Nakagawa, H; Lu, FM; Rustgi, AK; Diehl, JA,期刊:Cancer Cell, 页码:68-78 , 文章类型: Article,,卷期:2008年14-1]
- SCFFbx4 was recently identified as the E3 ligase for cyclin D1. We now describe cell-cycle-dependent phosphorylation and dimerization of Fbx4 that is regulated by GSK3 beta and is defective in human cancer. We present da...
- Induction of EMT by twist proteins as a collateral effect of tumor-promoting inactivation of premature senescence
[作者:Ansieau, S; Bastid, J; Doreau, A; Morel, AP; Bouchet, BP; Thomas, C; Fauvet, F; Puisieux, I; Doglioni, C; Piccinin, S; Maestro, R; Voeltzel, T; Selmi, A; Valsesia-Wittmann, S; de Fromentel, CC; Puisieux, A,期刊:Cancer Cell, 页码:79-89 , 文章类型: Article,,卷期:2008年14-1]
- Twist1 and Twist2 are major regulators of embryogenesis. Twist1 has been shown to favor the metastatic dissemination of cancer cells through its ability to induce an epithelial-mesenchymal transition (EMT). Here, we show...
- A molecule targeting VHL-deficient renal cell carcinoma that induces autophagy
[作者:Turcotte, S; Chan, DA; Sutphin, PD; Hay, MP; Denny, WA; Giaccia, AJ,期刊:Cancer Cell, 页码:90-102 , 文章类型: Article,,卷期:2008年14-1]
- Renal cell carcinomas (RCCs) are refractory to standard therapies. The von Hippel-Lindau (VHL) tumor suppressor gene is inactivated in 75% of RCCs. By screening for small molecules selectively targeting VHL-deficient RCC...
|